{"id":3341,"date":"2021-04-21T14:35:11","date_gmt":"2021-04-21T05:35:11","guid":{"rendered":"https:\/\/www.emukk.com\/WP\/?p=3341"},"modified":"2021-07-21T23:16:35","modified_gmt":"2021-07-21T14:16:35","slug":"%e3%82%a4%e3%83%8c%e3%82%a8%e3%83%b3%e3%82%b8%e3%83%a5%e3%83%ac%e3%82%af%e3%83%81%e3%83%b3%ef%bc%88mal%ef%bc%89%e3%81%8cace2%e3%80%81adam17%e3%80%81furin%e3%81%ae%e7%99%ba%e7%8f%be%e3%82%92%e5%a4%a7","status":"publish","type":"post","link":"https:\/\/www.emukk.com\/WP\/%e3%82%a4%e3%83%8c%e3%82%a8%e3%83%b3%e3%82%b8%e3%83%a5%e3%83%ac%e3%82%af%e3%83%81%e3%83%b3%ef%bc%88mal%ef%bc%89%e3%81%8cace2%e3%80%81adam17%e3%80%81furin%e3%81%ae%e7%99%ba%e7%8f%be%e3%82%92%e5%a4%a7\/","title":{"rendered":"\u30a4\u30cc\u30a8\u30f3\u30b8\u30e5\u30ec\u30af\u30c1\u30f3\uff08MAL\uff09\u304cACE2\u3001ADAM17\u3001Furin\u3089\u306e\u767a\u73fe\u3092\u5927\u5e45\u306b\u6291\u5236\u3059\u308b\uff1aSARS-CoV-2\u306e\u611f\u67d3\u306e\u6291\u5236\u306b\u65b0\u77e5\u898b"},"content":{"rendered":"<p>Rowan University, Stratford, USA\u3089\u306e\u30b0\u30eb\u30fc\u30d7\u306f\u3001\u30a4\u30cc\u30a8\u30f3\u30b8\u30e5\u30ec\u30af\u30c1\u30f3\uff08MAL, MAA, MASL\u3089\u304c\u547c\u79f0\uff09\u304cSARS-CoV-2\u306e\u611f\u67d3\u6291\u5236\u306b\u6709\u52b9\u3067\u3042\u308b\u304b\u3082\u77e5\u308c\u306a\u3044\u3068\u8ff0\u3079\u3066\u3044\u307e\u3059\u3002<br \/>\n<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC8019238\/\">https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC8019238\/<\/a><\/p>\n<p>\u53e3\u8154\u6241\u5e73\u4e0a\u76ae\u7d30\u80de\u3092\u30e2\u30c7\u30eb\u7d30\u80de\u3068\u3057\u3066\u3001\u30a4\u30cc\u30a8\u30f3\u30b8\u30e5\u30ec\u30af\u30c1\u30f3\uff08MAL\uff09\u304cACE2, ADAM17, Furin, \u7cd6\u8ee2\u79fb\u9175\u7d20\uff08GalNAc-T, ST6GalNAc-1, and ST6GalNAc-2\uff09\u306e\u767a\u73fe\u306b\u4e0e\u3048\u308b\u5f71\u97ff\u3092\u30c8\u30e9\u30f3\u30b9\u30af\u30ea\u30d7\u30c8\u30fc\u30e0\u89e3\u6790\u306b\u3066\u8abf\u3079\u307e\u3057\u305f\u3002<br \/>\n\u8208\u5473\u6df1\u3044\u3053\u3068\u306b\u3001\u3053\u308c\u3089\u304cMAL\u306edose\u306b\u4f9d\u5b58\u3057\u305f\u5f62\u3067\u6e1b\u5c11\u3059\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u307e\u3057\u305f\u3002\u4f8b\u3048\u3070\u30011925nM\u306eMAL\u306e\u6dfb\u52a0\u306b\u3066\u3001ACE2\u306emRNA\u767a\u73fe\u306f60\uff05\u4f4e\u4e0b\u3001ADAM17\u306f40\uff05\u4f4e\u4e0b\u3001ST6GalNAc-1\u308260\uff05\u4f4e\u4e0b\u3057\u3066\u3044\u307e\u3059\u3002\u3053\u308c\u3089\u306e\u7d50\u679c\u3068\u3057\u3066\u3001\u708e\u75c7\u6027\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u306e\u767a\u73fe\u3092\u8a98\u8d77\u3059\u308b\u30b7\u30b0\u30ca\u30eb\u6e90\u304c\u6e1b\u5c11\u3057\u3001\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u30b9\u30c8\u30fc\u30e0\u306e\u6291\u5236\u306b\u3082\u3064\u306a\u304c\u308a\u307e\u3059\u3002<\/p>\n<p>\u306a\u304a\u3001MAL\u306f\u3001\u03b12-3Sia\u306b\u7cd6\u9396\u7d50\u5408\u7279\u7570\u6027\u3092\u6301\u3064\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n<p><a href=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/04\/ACE2-ADAM17-Furin-Glycosylases_MAL.png\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/04\/ACE2-ADAM17-Furin-Glycosylases_MAL-300x102.png\" alt=\"\" width=\"300\" height=\"102\" class=\"alignleft size-medium wp-image-3342\" srcset=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/04\/ACE2-ADAM17-Furin-Glycosylases_MAL-300x102.png 300w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/04\/ACE2-ADAM17-Furin-Glycosylases_MAL-600x204.png 600w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/04\/ACE2-ADAM17-Furin-Glycosylases_MAL.png 623w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Rowan University, Stratford, USA\u3089\u306e\u30b0\u30eb\u30fc\u30d7\u306f\u3001\u30a4\u30cc\u30a8\u30f3\u30b8\u30e5\u30ec\u30af\u30c1\u30f3\uff08MAL, MAA, MASL\u3089\u304c\u547c\u79f0\uff09\u304cSARS-CoV-2\u306e\u611f\u67d3\u6291\u5236\u306b\u6709\u52b9\u3067\u3042\u308b\u304b\u3082\u77e5\u308c\u306a\u3044\u3068\u8ff0\u3079\u3066\u3044\u307e\u3059\u3002 htt<\/p><\/div>\n<div class=\"blog-btn\"><a href=\"https:\/\/www.emukk.com\/WP\/%e3%82%a4%e3%83%8c%e3%82%a8%e3%83%b3%e3%82%b8%e3%83%a5%e3%83%ac%e3%82%af%e3%83%81%e3%83%b3%ef%bc%88mal%ef%bc%89%e3%81%8cace2%e3%80%81adam17%e3%80%81furin%e3%81%ae%e7%99%ba%e7%8f%be%e3%82%92%e5%a4%a7\/\" class=\"home-blog-btn\">\u7d9a\u304d\u3092\u8aad\u3080<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[642],"tags":[],"class_list":["post-3341","post","type-post","status-publish","format-standard","hentry","category-nature-ja"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/3341","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/comments?post=3341"}],"version-history":[{"count":7,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/3341\/revisions"}],"predecessor-version":[{"id":5101,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/3341\/revisions\/5101"}],"wp:attachment":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/media?parent=3341"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/categories?post=3341"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/tags?post=3341"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}