{"id":3338,"date":"2021-04-21T10:42:54","date_gmt":"2021-04-21T01:42:54","guid":{"rendered":"https:\/\/www.emukk.com\/WP\/?p=3332"},"modified":"2021-04-23T06:04:37","modified_gmt":"2021-04-22T21:04:37","slug":"functional-roles-of-dexamethason-as-a-therapeutic-drug-for-covid-19","status":"publish","type":"post","link":"https:\/\/www.emukk.com\/WP\/en\/functional-roles-of-dexamethason-as-a-therapeutic-drug-for-covid-19\/","title":{"rendered":"Functional Roles of Dexamethason as a therapeutic drug for COVID-19\u00a0"},"content":{"rendered":"<p>As a special case, Japanese Ministry of Health, Labor and Welfare approved &#8220;Remdesivir&#8221; as a therapeutic drug for COVID-19 in May, 2020. In Sept., 2020, Dexamathason as a corticosteroid was also approved as a therapeutic drug for COVID-19. Let me introduce a paper explaining what kinds of functional roles Dexamethason plays.<\/p>\n<p>It is a paper from a group of University of Huddersfield, UK, etc.<br \/>\n<a href=\"https:\/\/link.springer.com\/article\/10.1007\/s10753-021-01464-5\">https:\/\/link.springer.com\/article\/10.1007\/s10753-021-01464-5<\/a><\/p>\n<p>Stimulation of human PBMCs with a recombinant spike glycoprotein S1 resulted in significant release of pro-inflammatory cytokines TNF\u03b1, IL-6, IL-1\u03b2 and IL-8. Pre-treatment with dexamethasone (100 nM) caused significant reduction in the release of these cytokines. SARS-CoV-2 spike glycoprotein S1 induced exaggerated inflammation in PBMCs through mechanisms involving activation of NF-\u03baB transcription factor, p38 MAPK and the NLRP3 inflammasome, and it was found that the pre-treating PBMCs with dexamethasone inhibited NF-\u03baB DNA binding by \uff5e46%. <\/p>\n<p><a href=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/04\/Dexamethasone_COVID-19-1.png\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/04\/Dexamethasone_COVID-19-1-300x162.png\" alt=\"\" width=\"300\" height=\"162\" class=\"alignleft size-medium wp-image-3334\" srcset=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/04\/Dexamethasone_COVID-19-1-300x162.png 300w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/04\/Dexamethasone_COVID-19-1-600x325.png 600w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/04\/Dexamethasone_COVID-19-1.png 685w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>As a special case, Japanese Ministry of Health, Labor and Welfare approved &#8220;Remdesivir&#8221; as a thera<\/p><\/div>\n<div class=\"blog-btn\"><a href=\"https:\/\/www.emukk.com\/WP\/en\/functional-roles-of-dexamethason-as-a-therapeutic-drug-for-covid-19\/\" class=\"home-blog-btn\">\u7d9a\u304d\u3092\u8aad\u3080<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[7],"tags":[],"class_list":["post-3338","post","type-post","status-publish","format-standard","hentry","category-technology-en"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/3338","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/comments?post=3338"}],"version-history":[{"count":2,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/3338\/revisions"}],"predecessor-version":[{"id":3340,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/3338\/revisions\/3340"}],"wp:attachment":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/media?parent=3338"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/categories?post=3338"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/tags?post=3338"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}