{"id":3338,"date":"2021-04-21T10:42:54","date_gmt":"2021-04-21T01:42:54","guid":{"rendered":"https:\/\/www.emukk.com\/WP\/?p=3332"},"modified":"2021-04-23T06:04:37","modified_gmt":"2021-04-22T21:04:37","slug":"functional-roles-of-dexamethason-as-a-therapeutic-drug-for-covid-19","status":"publish","type":"post","link":"https:\/\/www.emukk.com\/WP\/en\/functional-roles-of-dexamethason-as-a-therapeutic-drug-for-covid-19\/","title":{"rendered":"Functional Roles of Dexamethason as a therapeutic drug for COVID-19\u00a0"},"content":{"rendered":"

As a special case, Japanese Ministry of Health, Labor and Welfare approved “Remdesivir” as a therapeutic drug for COVID-19 in May, 2020. In Sept., 2020, Dexamathason as a corticosteroid was also approved as a therapeutic drug for COVID-19. Let me introduce a paper explaining what kinds of functional roles Dexamethason plays.<\/p>\n

It is a paper from a group of University of Huddersfield, UK, etc.
\nhttps:\/\/link.springer.com\/article\/10.1007\/s10753-021-01464-5<\/a><\/p>\n

Stimulation of human PBMCs with a recombinant spike glycoprotein S1 resulted in significant release of pro-inflammatory cytokines TNF\u03b1, IL-6, IL-1\u03b2 and IL-8. Pre-treatment with dexamethasone (100 nM) caused significant reduction in the release of these cytokines. SARS-CoV-2 spike glycoprotein S1 induced exaggerated inflammation in PBMCs through mechanisms involving activation of NF-\u03baB transcription factor, p38 MAPK and the NLRP3 inflammasome, and it was found that the pre-treating PBMCs with dexamethasone inhibited NF-\u03baB DNA binding by \uff5e46%. <\/p>\n

\"\"<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

As a special case, Japanese Ministry of Health, Labor and Welfare approved “Remdesivir” as a thera<\/p><\/div>\n

\u7d9a\u304d\u3092\u8aad\u3080<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[7],"tags":[],"class_list":["post-3338","post","type-post","status-publish","format-standard","hentry","category-technology-en"],"aioseo_notices":[],"aioseo_head":"\n\t\t\n\t\n\t\n\t\n\t\n\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t