{"id":3272,"date":"2021-04-18T09:04:38","date_gmt":"2021-04-18T00:04:38","guid":{"rendered":"https:\/\/www.emukk.com\/WP\/?p=3267"},"modified":"2021-04-18T10:10:28","modified_gmt":"2021-04-18T01:10:28","slug":"differences-in-sars-cov-2-infectivity-between-m1-macrophages-and-m2-macrophages","status":"publish","type":"post","link":"https:\/\/www.emukk.com\/WP\/en\/differences-in-sars-cov-2-infectivity-between-m1-macrophages-and-m2-macrophages\/","title":{"rendered":"Differences in SARS-CoV-2 infectivity between M1 alveoli macrophages and M2 macrophages\u00a0"},"content":{"rendered":"<p>A group from Peking Union Medical College, etc. has reported on differences in SARS-CoV-2 infectivity between M1 macrophages and M2 macrophages including alveolar epithelial type II (AT2) cells.<br \/>\n<a href=\"https:\/\/www.nature.com\/articles\/s41421-021-00258-1\">https:\/\/www.nature.com\/articles\/s41421-021-00258-1<\/a><\/p>\n<p>Generally speaking, M1 macrophages are inflammatory and M2 macrophages are anti-inflammatory. Comparing AT2, M1 macrophages, and M2 macrophages, SARS-CoV-2 infection and its replication was higher in macrophages than AT2, M1 macrophages took up SARS-CoV-w2 with higher efficiency than M2 macrophages, and the viral loads increased in an exponential fashion in M1 macrophages but in a flat fashion in M2 macrophages. It is considered that ACE2 could be the receptor that mediates the infection with SARS-CoV-2, and ACE2 has been reported to be expressed also by macrophages. However, there were no difference in the infectivity between ACE2-overexpressing macrophages and ACE2-knockeddown macrophages. So, virus takeup through phagocytosis could initiate SARS-CoBV-2 infection.<br \/>\nAuthors related the difference in the infectivity between M1 and M2 to difference in cell softness, endosomal, and lysosomal pH.<\/p>\n<p><a href=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/04\/M1-M2_SARS-CoV-2-infection.png\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/04\/M1-M2_SARS-CoV-2-infection-300x142.png\" alt=\"\" width=\"300\" height=\"142\" class=\"alignleft size-medium wp-image-3269\" srcset=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/04\/M1-M2_SARS-CoV-2-infection-300x142.png 300w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/04\/M1-M2_SARS-CoV-2-infection.png 495w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>A group from Peking Union Medical College, etc. has reported on differences in SARS-CoV-2 infectivity between <\/p><\/div>\n<div class=\"blog-btn\"><a href=\"https:\/\/www.emukk.com\/WP\/en\/differences-in-sars-cov-2-infectivity-between-m1-macrophages-and-m2-macrophages\/\" class=\"home-blog-btn\">\u7d9a\u304d\u3092\u8aad\u3080<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[70],"tags":[],"class_list":["post-3272","post","type-post","status-publish","format-standard","hentry","category-nature-en"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/3272","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/comments?post=3272"}],"version-history":[{"count":3,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/3272\/revisions"}],"predecessor-version":[{"id":3275,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/3272\/revisions\/3275"}],"wp:attachment":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/media?parent=3272"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/categories?post=3272"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/tags?post=3272"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}