{"id":3234,"date":"2021-04-14T11:19:05","date_gmt":"2021-04-14T02:19:05","guid":{"rendered":"https:\/\/www.emukk.com\/WP\/?p=3212"},"modified":"2021-04-14T11:52:17","modified_gmt":"2021-04-14T02:52:17","slug":"il-33-expression-in-covid-19-covalescent-individuals-correlates-with-seropositivity-of-sars-cov-2-specific-igg","status":"publish","type":"post","link":"https:\/\/www.emukk.com\/WP\/en\/il-33-expression-in-covid-19-covalescent-individuals-correlates-with-seropositivity-of-sars-cov-2-specific-igg\/","title":{"rendered":"IL-33 expression in COVID-19 covalescent individuals correlates with seropositivity of SARS-CoV-2 specific IgG"},"content":{"rendered":"

A group from Max Planck Institute of Immunobiology and Epigenetics, etc. has found that IL-33 expression in COVID-19 covalescent individuals correlates with seropositivity of SARS-CoV-2 specific IgG.
\nhttps:\/\/www.nature.com\/articles\/s41467-021-22449-w<\/a><\/p>\n

Authors purified PBMCs from COVID-19 covalescent 20 individuals and examined their composition using conventional CD markers, and monitored cytokine production with activation following SARS-CoV-2 Spike stimulation. It was found that IL-33 was most strongly correlated with CD4+<\/sup>CD69+<\/sup> T-cells among cytokines investigated here, IL-33, IL-6, IFN-\u02512, and IL-23. IL-33 has a high homology amino acid sequence with IL-1\u03b2 and IL-18 and belongs to the IL-1 family, but its detailed characteristics are still unknow. Authors have investigated the source of IL-33 in PBMCs by staining for intracellular IL-33 in conjunction with cell-specific markers, and found that it was most highly expressed in CD14+ monocytes. However, there were no differences in the frequency of IL-33+ cells in PBMC from seropositive vs. seronegative individuals, suggesting that the emergence of COVID-19-specific T cells that are capable of eliciting the release of bioactive IL-33 from other cells that constitutively produce this cytokine. These results suggest that IL-33 might be deeply linked to COVID-19 pathogenesis and immunity.<\/p>\n

\"\"<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

A group from Max Planck Institute of Immunobiology and Epigenetics, etc. has found that IL-33 expression in CO<\/p><\/div>\n

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