{"id":3234,"date":"2021-04-14T11:19:05","date_gmt":"2021-04-14T02:19:05","guid":{"rendered":"https:\/\/www.emukk.com\/WP\/?p=3212"},"modified":"2021-04-14T11:52:17","modified_gmt":"2021-04-14T02:52:17","slug":"il-33-expression-in-covid-19-covalescent-individuals-correlates-with-seropositivity-of-sars-cov-2-specific-igg","status":"publish","type":"post","link":"https:\/\/www.emukk.com\/WP\/en\/il-33-expression-in-covid-19-covalescent-individuals-correlates-with-seropositivity-of-sars-cov-2-specific-igg\/","title":{"rendered":"IL-33 expression in COVID-19 covalescent individuals correlates with seropositivity of SARS-CoV-2 specific IgG"},"content":{"rendered":"<p>A group from Max Planck Institute of Immunobiology and Epigenetics, etc. has found that IL-33 expression in COVID-19 covalescent individuals correlates with seropositivity of SARS-CoV-2 specific IgG.<br \/>\n<a href=\"https:\/\/www.nature.com\/articles\/s41467-021-22449-w\">https:\/\/www.nature.com\/articles\/s41467-021-22449-w<\/a><\/p>\n<p>Authors purified PBMCs from COVID-19 covalescent 20 individuals and examined their composition using conventional CD markers, and monitored cytokine production with activation following SARS-CoV-2 Spike stimulation. It was found that IL-33 was most strongly correlated with CD4<sup>+<\/sup>CD69<sup>+<\/sup> T-cells among cytokines investigated here, IL-33, IL-6, IFN-\u02512, and IL-23. IL-33 has a high homology amino acid sequence with IL-1\u03b2 and IL-18 and belongs to the IL-1 family, but its detailed characteristics are still unknow. Authors have investigated the source of IL-33 in PBMCs by staining for intracellular IL-33 in conjunction with cell-specific markers, and found that it was most highly expressed in CD14+ monocytes. However, there were no differences in the frequency of IL-33+ cells in PBMC from seropositive vs. seronegative individuals, suggesting that the emergence of COVID-19-specific T cells that are capable of eliciting the release of bioactive IL-33 from other cells that constitutively produce this cytokine. These results suggest that IL-33 might be deeply linked to COVID-19 pathogenesis and immunity.<\/p>\n<p><a href=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/04\/IL33_CD4CD69_correlation_SARS-CoV-2-1.png\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/04\/IL33_CD4CD69_correlation_SARS-CoV-2-1.png\" alt=\"\" width=\"869\" height=\"253\" class=\"alignleft size-full wp-image-3227\" srcset=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/04\/IL33_CD4CD69_correlation_SARS-CoV-2-1.png 869w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/04\/IL33_CD4CD69_correlation_SARS-CoV-2-1-600x175.png 600w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/04\/IL33_CD4CD69_correlation_SARS-CoV-2-1-300x87.png 300w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/04\/IL33_CD4CD69_correlation_SARS-CoV-2-1-768x224.png 768w\" sizes=\"auto, (max-width: 869px) 100vw, 869px\" \/><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>A group from Max Planck Institute of Immunobiology and Epigenetics, etc. has found that IL-33 expression in CO<\/p><\/div>\n<div class=\"blog-btn\"><a href=\"https:\/\/www.emukk.com\/WP\/en\/il-33-expression-in-covid-19-covalescent-individuals-correlates-with-seropositivity-of-sars-cov-2-specific-igg\/\" class=\"home-blog-btn\">\u7d9a\u304d\u3092\u8aad\u3080<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[70],"tags":[],"class_list":["post-3234","post","type-post","status-publish","format-standard","hentry","category-nature-en"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/3234","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/comments?post=3234"}],"version-history":[{"count":2,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/3234\/revisions"}],"predecessor-version":[{"id":3236,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/3234\/revisions\/3236"}],"wp:attachment":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/media?parent=3234"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/categories?post=3234"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/tags?post=3234"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}