{"id":3222,"date":"2021-04-13T15:41:24","date_gmt":"2021-04-13T06:41:24","guid":{"rendered":"https:\/\/www.emukk.com\/WP\/?p=3214"},"modified":"2021-04-14T11:58:06","modified_gmt":"2021-04-14T02:58:06","slug":"a-polyphenol-from-green-tea-gcg-could-inhibit-sars-cov-2-replication-effectively","status":"publish","type":"post","link":"https:\/\/www.emukk.com\/WP\/en\/a-polyphenol-from-green-tea-gcg-could-inhibit-sars-cov-2-replication-effectively\/","title":{"rendered":"A polyphenol from green tea (GCG) could inhibit SARS-CoV-2 replication effectively"},"content":{"rendered":"<p>A group from Fudan University, etc. has shown that Gallocatechin gallate (GCG), a polyphenol from green tea, inhibits SARS-CoV-2 replication efficiently.<br \/>\n<a href=\"https:\/\/www.nature.com\/articles\/s41467-021-22297-8\">https:\/\/www.nature.com\/articles\/s41467-021-22297-8<\/a><\/p>\n<p>SARS-CoV-2 N protein is a structural protein binding to RNA, and form a  shell embracing SARS-CoV-2 RNA. This is a typical example of so called Liquid-Liquid Phase Separation (LLPS) which is a mechanism in organizing macromolecules such as proteins and RNAs into membrane-less oil droplet like organelles.<br \/>\nAuthors has shown that GCG could could inhibit N protein LLPS in the context of SARS-CoV-2 infection effectively. Since, the amino acid sequence shares \uff5e90% homology among corona viruses, targeting N protein by GCG could be a novel drug candidate not only for SARS-CoV-2 but also for new coronaviruses in the future.<\/p>\n<p><a href=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/04\/GCG_LLPC-inhibition.png\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/04\/GCG_LLPC-inhibition-300x119.png\" alt=\"\" width=\"300\" height=\"119\" class=\"alignleft size-medium wp-image-3218\" srcset=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/04\/GCG_LLPC-inhibition-300x119.png 300w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/04\/GCG_LLPC-inhibition-600x238.png 600w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/04\/GCG_LLPC-inhibition.png 613w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>A group from Fudan University, etc. has shown that Gallocatechin gallate (GCG), a polyphenol from green tea, i<\/p><\/div>\n<div class=\"blog-btn\"><a href=\"https:\/\/www.emukk.com\/WP\/en\/a-polyphenol-from-green-tea-gcg-could-inhibit-sars-cov-2-replication-effectively\/\" class=\"home-blog-btn\">\u7d9a\u304d\u3092\u8aad\u3080<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[7],"tags":[],"class_list":["post-3222","post","type-post","status-publish","format-standard","hentry","category-technology-en"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/3222","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/comments?post=3222"}],"version-history":[{"count":2,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/3222\/revisions"}],"predecessor-version":[{"id":3224,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/3222\/revisions\/3224"}],"wp:attachment":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/media?parent=3222"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/categories?post=3222"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/tags?post=3222"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}