{"id":3212,"date":"2021-04-14T11:19:05","date_gmt":"2021-04-14T02:19:05","guid":{"rendered":"https:\/\/www.emukk.com\/WP\/?p=3212"},"modified":"2021-07-21T23:19:44","modified_gmt":"2021-07-21T14:19:44","slug":"covid-19%e3%81%ab%e3%81%8a%e3%81%91%e3%82%8bil-33%e3%81%ae%e7%99%ba%e7%8f%be%e3%81%8c%e3%80%81%e5%9b%9e%e5%be%a9%e6%9c%9f%e8%a1%80%e6%b8%85%e9%99%bd%e6%80%a7%e7%8e%87%e3%81%a8%e7%9b%b8%e9%96%a2","status":"publish","type":"post","link":"https:\/\/www.emukk.com\/WP\/covid-19%e3%81%ab%e3%81%8a%e3%81%91%e3%82%8bil-33%e3%81%ae%e7%99%ba%e7%8f%be%e3%81%8c%e3%80%81%e5%9b%9e%e5%be%a9%e6%9c%9f%e8%a1%80%e6%b8%85%e9%99%bd%e6%80%a7%e7%8e%87%e3%81%a8%e7%9b%b8%e9%96%a2\/","title":{"rendered":"COVID-19\u306b\u304a\u3051\u308bIL-33\u306e\u767a\u73fe\u304c\u3001\u56de\u5fa9\u671f\u8840\u6e05\u967d\u6027\u7387\u3068\u76f8\u95a2\u3057\u3066\u3044\u308b"},"content":{"rendered":"<p>Max Planck Institute of Immunobiology and Epigenetics\u3089\u306e\u30b0\u30eb\u30fc\u30d7\u306f\u3001COVID-19\u306e\u56de\u5fa9\u671f\u60a3\u8005\u306eSARS-CoV-2\u7279\u7570\u7684\u306aIgG\u306e\u8840\u6e05\u967d\u6027\u7387\u304cIL-33\u3068\u76f8\u95a2\u3057\u3066\u3044\u308b\u3053\u3068\u3092\u898b\u3064\u3051\u307e\u3057\u305f\u3002<br \/>\n<a href=\"https:\/\/www.nature.com\/articles\/s41467-021-22449-w\">https:\/\/www.nature.com\/articles\/s41467-021-22449-w<\/a><\/p>\n<p>\u8457\u8005\u3089\u306f\u3001COVID-19\u306e\u56de\u5fa9\u671f\u60a3\u8005\uff1d20\u540d\u304b\u3089\u672b\u68a2\u8840\u5358\u6838\u7d30\u80de\uff08PBMC\uff09\u3092\u5f97\u3066\u3001CD\u30de\u30fc\u30ab\u30fc\u306b\u3088\u308b\u305d\u306e\u7d30\u80de\u69cb\u6210\u306e\u628a\u63e1\u3068\u3001SARS-CoV-2 Spike\u306b\u3088\u308b\u523a\u6fc0\u3092\u4e0e\u3048\u305f\u5834\u5408\u306e\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u306e\u767a\u73fe\u3092\u8a55\u4fa1\u3057\u3066\u3044\u307e\u3059\u3002IL-33, IL-6, IFN-\u02512, IL-23\u3089\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u306e\u7523\u751f\u3068CD4<sup>+<\/sup>CD69<sup>+<\/sup> T\u7d30\u80de\u306e\u76f8\u95a2\u3092\u8abf\u3079\u308b\u3068\u3001IL-33\u304c\u6700\u3082\u5f37\u304fCD4<sup>+<\/sup>CD69<sup>+<\/sup> T\u7d30\u80de\u3068\u76f8\u95a2\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u5206\u304b\u308a\u307e\u3057\u305f\u3002IL-33\u306fIL-1\u03b2\u3084IL-18\u3068\u76f8\u540c\u6027\u306e\u9ad8\u3044\u30a2\u30df\u30ce\u9178\u914d\u5217\u3092\u6709\u3059\u308bIL-1 \u30d5\u30a1\u30df\u30ea\u30fc\u306b\u5c5e\u3059\u308b\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u3068\u3055\u308c\u3066\u3044\u307e\u3059\u304c\u3001\u672a\u89e3\u660e\u306e\u90e8\u5206\u3082\u591a\u3044\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u3067\u3059\u3002IL-33\u3092\u7523\u751f\u3059\u308b\u7d30\u80de\u304c\u4f55\u306a\u306e\u304b\u306b\u3064\u3044\u3066\u306f\u3001CD14\u5358\u7403\u3067\u6700\u3082\u9ad8\u767a\u73fe\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u5206\u304b\u308a\u307e\u3057\u305f\u304c\u3001\u8840\u6e05\u967d\u6027\u8005\u3068\u8840\u6e05\u9670\u6027\u8005\u306e\u9593\u3067\u5dee\u304c\u898b\u3089\u308c\u305a\u3001\u5f93\u3063\u3066IL-33\u3092\u69cb\u6210\u7684\u306b\u4f5c\u308b\u3053\u3068\u304c\u3067\u304d\u308b\u4ed6\u306e\u7d30\u80de\u304b\u3089\u751f\u7406\u6d3b\u6027\u3092\u6301\u3064IL-33\u306e\u7523\u751f\u3092\u5f15\u304d\u51fa\u3059\u3053\u3068\u304c\u3067\u304d\u308bCOVID-19\u7279\u7570\u7684\u306aT\u7d30\u80de\u304c\u95a2\u4fc2\u3057\u3066\u3044\u308b\u53ef\u80fd\u6027\u304c\u6307\u6458\u3055\u308c\u307e\u3059\u3002\u3053\u308c\u3089\u306e\u7d50\u679c\u306f\u3001IL-33\u304cCOVID-19\u306e\u75c5\u56e0\u306b\u95a2\u4e0e\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3053\u3068\u3092\u793a\u5506\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n<p><a href=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/04\/IL33_CD4CD69_correlation_SARS-CoV-2-1.png\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/04\/IL33_CD4CD69_correlation_SARS-CoV-2-1.png\" alt=\"\" width=\"869\" height=\"253\" class=\"alignleft size-full wp-image-3227\" srcset=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/04\/IL33_CD4CD69_correlation_SARS-CoV-2-1.png 869w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/04\/IL33_CD4CD69_correlation_SARS-CoV-2-1-600x175.png 600w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/04\/IL33_CD4CD69_correlation_SARS-CoV-2-1-300x87.png 300w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/04\/IL33_CD4CD69_correlation_SARS-CoV-2-1-768x224.png 768w\" sizes=\"auto, (max-width: 869px) 100vw, 869px\" \/><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Max Planck Institute of Immunobiology and Epigenetics\u3089\u306e\u30b0\u30eb\u30fc\u30d7\u306f\u3001COVID-19\u306e\u56de\u5fa9\u671f\u60a3\u8005\u306eSARS-CoV-2\u7279\u7570\u7684\u306aIgG\u306e\u8840\u6e05\u967d\u6027\u7387\u304cIL-33\u3068\u76f8\u95a2\u3057\u3066<\/p><\/div>\n<div class=\"blog-btn\"><a href=\"https:\/\/www.emukk.com\/WP\/covid-19%e3%81%ab%e3%81%8a%e3%81%91%e3%82%8bil-33%e3%81%ae%e7%99%ba%e7%8f%be%e3%81%8c%e3%80%81%e5%9b%9e%e5%be%a9%e6%9c%9f%e8%a1%80%e6%b8%85%e9%99%bd%e6%80%a7%e7%8e%87%e3%81%a8%e7%9b%b8%e9%96%a2\/\" class=\"home-blog-btn\">\u7d9a\u304d\u3092\u8aad\u3080<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[642],"tags":[],"class_list":["post-3212","post","type-post","status-publish","format-standard","hentry","category-nature-ja"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/3212","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/comments?post=3212"}],"version-history":[{"count":9,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/3212\/revisions"}],"predecessor-version":[{"id":5108,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/3212\/revisions\/5108"}],"wp:attachment":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/media?parent=3212"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/categories?post=3212"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/tags?post=3212"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}