{"id":3175,"date":"2021-04-10T06:59:24","date_gmt":"2021-04-09T21:59:24","guid":{"rendered":"https:\/\/www.emukk.com\/WP\/?p=3171"},"modified":"2021-04-10T07:09:36","modified_gmt":"2021-04-09T22:09:36","slug":"il-1r7-antibody-would-be-effective-in-covid-19-to-suppress-cytokine-storms","status":"publish","type":"post","link":"https:\/\/www.emukk.com\/WP\/en\/il-1r7-antibody-would-be-effective-in-covid-19-to-suppress-cytokine-storms\/","title":{"rendered":"IL-1R7 antibody would be effective in COVID-19 to suppress cytokine storms"},"content":{"rendered":"<p>A group from University of Colorado Denver Anschutz Medical Campus has reported that IL-1R7 antibody would be effective in COVID-19 to suppress cytokine storms.<br \/>\n<a href=\"https:\/\/www.jbc.org\/article\/S0021-9258(21)00416-6\/fulltext\">https:\/\/www.jbc.org\/article\/S0021-9258(21)00416-6\/fulltext<\/a><\/p>\n<p>Excessive inflammation observed in macrophage activation syndrome (MAS) results in severe diseases with high mortality. The cytokine storms observed in COVID-19 patients would be a typical example similar to MAS.<br \/>\nInterleukin-18 (IL-18), a proinflammatory cytokine belonging to the IL-1 family, is elevated in both MAS and COVID-19 patients, and its level is known to correlate with the severity of COVID-19 symptoms<\/p>\n<p>IL-18 binds its specific receptor IL-1 Receptor 5 (IL-1R5, also known as IL-18 Receptor alpha chain), leading to the recruitment of the co-receptor, IL-1 Receptor 7 (IL-1R7, also known as IL-18 Receptor beta chain). <\/p>\n<p>Authors found that the anti-IL-1R7 antibody significantly suppressed IL-18-mediated NF\u03baB activation, IL-18-stimulated IFN\u03b3 production, and IL-6 production in human cell lines.<\/p>\n<p><a href=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/04\/anti-IL-1R7_IL-6_COVID-19.png\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/04\/anti-IL-1R7_IL-6_COVID-19-300x202.png\" alt=\"\" width=\"300\" height=\"202\" class=\"alignleft size-medium wp-image-3173\" srcset=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/04\/anti-IL-1R7_IL-6_COVID-19-300x202.png 300w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/04\/anti-IL-1R7_IL-6_COVID-19-272x182.png 272w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/04\/anti-IL-1R7_IL-6_COVID-19.png 540w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>A group from University of Colorado Denver Anschutz Medical Campus has reported that IL-1R7 antibody would be <\/p><\/div>\n<div class=\"blog-btn\"><a href=\"https:\/\/www.emukk.com\/WP\/en\/il-1r7-antibody-would-be-effective-in-covid-19-to-suppress-cytokine-storms\/\" class=\"home-blog-btn\">\u7d9a\u304d\u3092\u8aad\u3080<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[7],"tags":[],"class_list":["post-3175","post","type-post","status-publish","format-standard","hentry","category-technology-en"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/3175","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/comments?post=3175"}],"version-history":[{"count":2,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/3175\/revisions"}],"predecessor-version":[{"id":3177,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/3175\/revisions\/3177"}],"wp:attachment":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/media?parent=3175"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/categories?post=3175"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/tags?post=3175"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}