{"id":3155,"date":"2021-04-08T10:41:33","date_gmt":"2021-04-08T01:41:33","guid":{"rendered":"https:\/\/www.emukk.com\/WP\/?p=3146"},"modified":"2021-04-08T11:28:15","modified_gmt":"2021-04-08T02:28:15","slug":"difference-in-site-specific-glycosylation-of-sars-cov-2-spike-proteins-all-recombinants-among-several-laboratories","status":"publish","type":"post","link":"https:\/\/www.emukk.com\/WP\/en\/difference-in-site-specific-glycosylation-of-sars-cov-2-spike-proteins-all-recombinants-among-several-laboratories\/","title":{"rendered":"Difference in site-specific glycosylation of SARS-CoV-2 spike proteins (all recombinants) among several laboratories"},"content":{"rendered":"<p>A group from University of Southampton, etc. has compared site-specific glycosylation of SARS-CoV-2 spike proteins (all recombinants) among five laboratories.<br \/>\nThe cells used for Sproten expression were as follows.<br \/>\nHEK293\uff1a Amsterdam, Harvard,<br \/>\nHEK293F\uff1a Southampton\/Texas,<br \/>\nHEK293T\uff1a Oxford,<br \/>\nCHO\uff1a Swiss,<br \/>\nIt is celarly shown that site-specific glycosylation changes considerablly with reflecting differences in cells and culture conditions.<br \/>\nFundamentally speaking, it is a mixture of oligo mannose and complex type N-glycans.<\/p>\n<p>Blog admin is interested in how much these differences cause difference in the infectivity, how glycosylation changes with SARS-CoV-2 mutations, and how much the glycosylation changes due to mutations affect the infectivity.<br \/>\n<a href=\"https:\/\/www.biorxiv.org\/content\/10.1101\/2021.03.08.433764v1.full\">https:\/\/www.biorxiv.org\/content\/10.1101\/2021.03.08.433764v1.full<\/a><\/p>\n<p><a href=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/04\/Glycosylation-difference_SARS-CoV-2-Spike-1.png\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/04\/Glycosylation-difference_SARS-CoV-2-Spike-1-300x211.png\" alt=\"\" width=\"300\" height=\"211\" class=\"alignleft size-medium wp-image-3152\" srcset=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/04\/Glycosylation-difference_SARS-CoV-2-Spike-1-300x211.png 300w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/04\/Glycosylation-difference_SARS-CoV-2-Spike-1-600x423.png 600w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/04\/Glycosylation-difference_SARS-CoV-2-Spike-1-1024x722.png 1024w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/04\/Glycosylation-difference_SARS-CoV-2-Spike-1-768x541.png 768w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/04\/Glycosylation-difference_SARS-CoV-2-Spike-1.png 1280w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>A group from University of Southampton, etc. has compared site-specific glycosylation of SARS-CoV-2 spike prot<\/p><\/div>\n<div class=\"blog-btn\"><a href=\"https:\/\/www.emukk.com\/WP\/en\/difference-in-site-specific-glycosylation-of-sars-cov-2-spike-proteins-all-recombinants-among-several-laboratories\/\" class=\"home-blog-btn\">\u7d9a\u304d\u3092\u8aad\u3080<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[7],"tags":[],"class_list":["post-3155","post","type-post","status-publish","format-standard","hentry","category-technology-en"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/3155","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/comments?post=3155"}],"version-history":[{"count":3,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/3155\/revisions"}],"predecessor-version":[{"id":3159,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/3155\/revisions\/3159"}],"wp:attachment":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/media?parent=3155"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/categories?post=3155"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/tags?post=3155"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}