{"id":3128,"date":"2021-04-06T13:32:30","date_gmt":"2021-04-06T04:32:30","guid":{"rendered":"https:\/\/www.emukk.com\/WP\/?p=3121"},"modified":"2021-04-06T14:02:07","modified_gmt":"2021-04-06T05:02:07","slug":"a-new-pathway-was-discovered-in-activation-of-the-complement-system-of-the-innate-immunity-masp-1-and-masp-3-have-dual-functions-as-enzymes-and-as-prms","status":"publish","type":"post","link":"https:\/\/www.emukk.com\/WP\/en\/a-new-pathway-was-discovered-in-activation-of-the-complement-system-of-the-innate-immunity-masp-1-and-masp-3-have-dual-functions-as-enzymes-and-as-prms\/","title":{"rendered":"A new pathway was discovered in activation of the complement system of the innate immunity: MASP-1 and MASP-3 have dual functions as enzymes and as PRMs\u00a0"},"content":{"rendered":"<p>In the lectin pathway as one of innate immunities, pattern recognition molecules (PRMs) (i.e., mannose-binding lectin (MBL), ficolins, and collectin-10\/-11) bind to pathogens recognizing specific molecular structures on the membranes, make complexes with MAPSs, activate complements sequentially, and finally form Membrane Attack Complex (MAC) on the membranes to kill pathogens.  <\/p>\n<p>However, a group from University of Copenhagen, etc. has reported a new pathway in which MAPSs directly bind to pathogens and activate the complement system using Aspergillus fumigatus as a pathogen. This means that a new pathway in the complement system was discovered showing MASP-1 and MASP-3 have dual functions as enzymes and as PRMs<br \/>\n<a href=\"https:\/\/www.karger.com\/Article\/FullText\/514546\">https:\/\/www.karger.com\/Article\/FullText\/514546<\/a><\/p>\n<p><a href=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/04\/Aspergillus-fumingatus_MASP-1.png\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/04\/Aspergillus-fumingatus_MASP-1-254x300.png\" alt=\"\" width=\"254\" height=\"300\" class=\"alignleft size-medium wp-image-3124\" srcset=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/04\/Aspergillus-fumingatus_MASP-1-254x300.png 254w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/04\/Aspergillus-fumingatus_MASP-1-600x710.png 600w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/04\/Aspergillus-fumingatus_MASP-1.png 649w\" sizes=\"auto, (max-width: 254px) 100vw, 254px\" \/><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>In the lectin pathway as one of innate immunities, pattern recognition molecules (PRMs) (i.e., mannose-binding<\/p><\/div>\n<div class=\"blog-btn\"><a href=\"https:\/\/www.emukk.com\/WP\/en\/a-new-pathway-was-discovered-in-activation-of-the-complement-system-of-the-innate-immunity-masp-1-and-masp-3-have-dual-functions-as-enzymes-and-as-prms\/\" class=\"home-blog-btn\">\u7d9a\u304d\u3092\u8aad\u3080<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[70],"tags":[],"class_list":["post-3128","post","type-post","status-publish","format-standard","hentry","category-nature-en"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/3128","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/comments?post=3128"}],"version-history":[{"count":2,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/3128\/revisions"}],"predecessor-version":[{"id":3130,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/3128\/revisions\/3130"}],"wp:attachment":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/media?parent=3128"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/categories?post=3128"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/tags?post=3128"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}