{"id":3085,"date":"2021-04-04T10:40:14","date_gmt":"2021-04-04T01:40:14","guid":{"rendered":"https:\/\/www.emukk.com\/WP\/?p=3085"},"modified":"2021-04-04T10:40:14","modified_gmt":"2021-04-04T01:40:14","slug":"sars-cov-2-spike%e3%82%bf%e3%83%b3%e3%83%91%e3%82%af%e8%b3%aa%e3%82%92%e3%83%8a%e3%83%8e%e7%b2%92%e5%ad%90%e5%8c%96%e3%81%97%e3%81%9f%e3%83%af%e3%82%af%e3%83%81%e3%83%b3%e3%82%92%e7%94%a8%e3%81%84","status":"publish","type":"post","link":"https:\/\/www.emukk.com\/WP\/sars-cov-2-spike%e3%82%bf%e3%83%b3%e3%83%91%e3%82%af%e8%b3%aa%e3%82%92%e3%83%8a%e3%83%8e%e7%b2%92%e5%ad%90%e5%8c%96%e3%81%97%e3%81%9f%e3%83%af%e3%82%af%e3%83%81%e3%83%b3%e3%82%92%e7%94%a8%e3%81%84\/","title":{"rendered":"SARS-CoV-2 Spike\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u30ca\u30ce\u7c92\u5b50\u5316\u3057\u305f\u30ef\u30af\u30c1\u30f3\u3092\u7528\u3044\u308b\u3053\u3068\u3067\u3001\u5909\u7570\u306b\u5f37\u3044\u5e83\u57df\u4e2d\u548c\u6297\u4f53\u306e\u751f\u6210\u3092\u4fc3\u3059\u3053\u3068\u304c\u3067\u304d\u308b"},"content":{"rendered":"<p>The Scripps Research Institute\u306f\u3001SARS-CoV-2 Spike\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u30ca\u30ce\u7c92\u5b50\u3092\u7528\u3044\u308b\u3053\u3068\u3067\u3001\u30a6\u30a4\u30eb\u30b9\u306e\u5909\u7570\u306b\u3082\u5f37\u3044\u5e83\u57df\u4e2d\u548c\u6297\u4f53\u3092\u4f5c\u308b\u3053\u3068\u304c\u3067\u304d\u308b\u3068\u3057\u3066\u3044\u307e\u3059\u3002<br \/>\n<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC8010731\/\">https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC8010731\/<\/a><\/p>\n<p>\u73fe\u5728\u306e\u30ef\u30af\u30c1\u30f3\u306e\u4e3b\u6d41\u306f\u3001recombinant SARS-CoV-2 spike\u3092\u6297\u539f\u3068\u3057\u3066\u63d0\u793a\u3059\u308b\u5f62\u306e\u30d7\u30e9\u30c3\u30c8\u30d5\u30a9\u30fc\u30e0\u3067\u3042\u308a\u3001mRNA\u3092\u5305\u542b\u3057\u305f\u30ea\u30dd\u30bd\u30fc\u30e0 (\u4f8b\u3048\u3070, BNT162b2 \u3084 mRNA-1273)\u3001\u30a2\u30c7\u30ce\u968f\u4f34\u30a6\u30a4\u30eb\u30b9\u30fb\u30d9\u30af\u30bf\u30fc\u3092\u7528\u3044\u305f\u3082\u306e (\u4f8b\u3048\u3070, ChAdOx1 nCoV-19 [AZD1222], CTII-nCoV, Sputnik V, \u3084 Ad26.COV2.S)\u3089\u304c\u5b58\u5728\u3057\u307e\u3059\u3002\u3053\u308c\u3089\u306e\u30ef\u30af\u30c1\u30f3\u306f\u3001B.1.1.7\u5909\u7570\u306b\u3064\u3044\u3066\u306f\u307e\u3060\u3057\u3082\u3001B.1.351\u3084P.1\u5909\u7570\u306b\u5bfe\u3057\u3066\u306f\u3001\u6709\u52b9\u6027\u304c\u9855\u8457\u306b\u4f4e\u4e0b\u3059\u308b\u3053\u3068\u304c\u6307\u6458\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u5f93\u3063\u3066\u3001\u30a6\u30a4\u30eb\u30b9\u5909\u7570\u306b\u5f37\u3044\u5e83\u57df\u4e2d\u548c\u6297\u4f53\u3092\u4f5c\u308b\u3053\u3068\u304c\u51fa\u6765\u308b\u30ef\u30af\u30c1\u30f3\u304c\u5207\u671b\u3055\u308c\u3066\u304a\u308a\u3001\u305d\u306e\u70ba\u306b\u306f\u3001\u6210\u719f\u3057\u305f\u6297\u4f53\u3092\u9577\u671f\u9593\u306b\u308f\u305f\u3063\u3066\u751f\u307f\u51fa\u305b\u308b\u80da\u4e2d\u5fc3\u306e\u5f62\u6210\u304c\u5fc5\u8981\u4e0d\u53ef\u6b20\u3067\u3059\u3002<\/p>\n<p>SARS-CoV-2 spike\u30bf\u30f3\u30d1\u30af\u8cea\u306f\u3001S1-S2\u30d8\u30c6\u30ed\u30c0\u30a4\u30de\u30fc\u306e\u4e09\u91cf\u4f53\u3092\u5f62\u6210\u3057\u3066\u3044\u307e\u3059\u3002S1 subunit\u306b\u306f\u3001\u611f\u67d3\u3092\u30a4\u30cb\u30b7\u30a8\u30fc\u30c8\u3059\u308bRBD\u304c\u542b\u307e\u308c\u3066\u304a\u308a\u3001S2 subunit\u306b\u306f\u3001fusion peptide (FP) \u3068 heptad repeat regions 1 \u3068 2 (HR1 \u3068 HR2)\u304c\u542b\u307e\u308c\u3066\u3044\u307e\u3059\u3002\u8457\u8005\u3089\u306f\u3001Spike\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u5b89\u5b9a\u6027\u3092\u9ad8\u3081\u308b\u305f\u3081\u306bHR2-deleted, glycine-capped\u306espike\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u30c7\u30b6\u30a4\u30f3\u3057 (S2G\u0394HR2)\u3001I3\u201301v9 60-mers\u3092\u30ea\u30f3\u30ab\u30fc\u3068\u3057\u3066\u30ca\u30ce\u7c92\u5b50\u5316\u3057\u305fS2G\u0394HR2-10GS-I3-01v9-LD7-PADRE (I3-01v9-L7P)\u3092\u30ef\u30af\u30c1\u30f3\u3068\u3057\u3066\u4f7f\u7528\u3057\u307e\u3057\u305f\u3002I3-01v9-L7P\u306b\u306f\u300120\u500b\u306eS2G\u0394HR2\u304c\u542b\u307e\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n<p>S2G\u0394HR2-10GS-I3-01v9-L7P\u3092\u30ef\u30af\u30c1\u30f3\u3068\u3057\u3066\u4f7f\u7528\u3059\u308b\u3053\u3068\u3067\u3001B.1.1.7, B.1.351, P.1 \u5909\u7570\u306b\u5bfe\u3057\u3066\u307b\u307c\u30b3\u30f3\u30d1\u30c1\u30d6\u30eb\u306a\u529b\u4fa1\u3092\u6709\u3059\u308b\u5e83\u57df\u4e2d\u548c\u6297\u4f53\u304c\u751f\u6210\u3055\u308c\u3066\u3044\u308b\u3053\u3068\u304c\u308f\u304b\u308a\u307e\u3057\u305f\u3002\u3053\u306e\u30ca\u30ce\u7c92\u5b50\u306f\u3001\u5358\u4f53Spike\u306b\u6bd4\u3079\u3066\u30016\u500d\u9577\u3044\u4fdd\u6301\u6642\u9593\u30014\u500d\u5927\u304d\u3044\u6ffe\u80de\u6a39\u72b6\u7d30\u80de\u7fa4\u30015\u500d\u9ad8\u3044\u80da\u4e2d\u5fc3\u306e\u6d3b\u52d5\u3092\u793a\u3057\u307e\u3057\u305f\u3002\u3053\u306e\u7406\u7531\u306b\u3064\u3044\u3066\u306f\u3001\u5b9a\u304b\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u304c\u3001\u30ef\u30af\u30c1\u30f3\u306e\u30b5\u30a4\u30ba\u52b9\u679c\u3060\u3068\u63a8\u6e2c\u3055\u308c\u307e\u3059\u3002<\/p>\n<p><a href=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/04\/S2G\u0394HR2-NP.png\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-large wp-image-3086\" src=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/04\/S2G\u0394HR2-NP-1024x321.png\" alt=\"\" width=\"696\" height=\"218\" srcset=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/04\/S2G\u0394HR2-NP-1024x321.png 1024w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/04\/S2G\u0394HR2-NP-600x188.png 600w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/04\/S2G\u0394HR2-NP-300x94.png 300w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/04\/S2G\u0394HR2-NP-768x240.png 768w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/04\/S2G\u0394HR2-NP.png 1166w\" sizes=\"auto, (max-width: 696px) 100vw, 696px\" \/><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>The Scripps Research Institute\u306f\u3001SARS-CoV-2 Spike\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u30ca\u30ce\u7c92\u5b50\u3092\u7528\u3044\u308b\u3053\u3068\u3067\u3001\u30a6\u30a4\u30eb\u30b9\u306e\u5909\u7570\u306b\u3082\u5f37\u3044\u5e83\u57df\u4e2d\u548c\u6297\u4f53\u3092\u4f5c\u308b\u3053\u3068\u304c\u3067\u304d\u308b\u3068\u3057\u3066\u3044\u307e\u3059\u3002 https:\/\/ww<\/p><\/div>\n<div class=\"blog-btn\"><a href=\"https:\/\/www.emukk.com\/WP\/sars-cov-2-spike%e3%82%bf%e3%83%b3%e3%83%91%e3%82%af%e8%b3%aa%e3%82%92%e3%83%8a%e3%83%8e%e7%b2%92%e5%ad%90%e5%8c%96%e3%81%97%e3%81%9f%e3%83%af%e3%82%af%e3%83%81%e3%83%b3%e3%82%92%e7%94%a8%e3%81%84\/\" class=\"home-blog-btn\">\u7d9a\u304d\u3092\u8aad\u3080<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[42],"tags":[],"class_list":["post-3085","post","type-post","status-publish","format-standard","hentry","category-technology-ja"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/3085","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/comments?post=3085"}],"version-history":[{"count":2,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/3085\/revisions"}],"predecessor-version":[{"id":3088,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/3085\/revisions\/3088"}],"wp:attachment":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/media?parent=3085"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/categories?post=3085"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/tags?post=3085"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}