{"id":3064,"date":"2021-04-01T05:29:24","date_gmt":"2021-03-31T20:29:24","guid":{"rendered":"http:\/\/www.emukk.com\/WP\/?p=3044"},"modified":"2021-04-01T05:34:26","modified_gmt":"2021-03-31T20:34:26","slug":"immune-memory-cd4t-cell-reaction-in-mild-covid-19-patients-and","status":"publish","type":"post","link":"https:\/\/www.emukk.com\/WP\/en\/immune-memory-cd4t-cell-reaction-in-mild-covid-19-patients-and\/","title":{"rendered":"Immune Memory (CD4+T-cell reaction) in mild COVID-19 patients and Cross-rectivity of CD4+T-cells against SARS-CoV-2 in unexposed donors"},"content":{"rendered":"<p>A group from National Institute of Immunology, New Delhi, etc. has reported on immune memory (CD4+T-cell reaction) in mild COVID-19 patients and cross-reactivity of CD4+T-cells against SARS-CoV-2 in unexposed donors<br \/>\n<a href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2021.636768\/full\">https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2021.636768\/full<\/a><\/p>\n<p>In mild COVID-19 patients, it was reported that the immune memory (i.e, CD4+T-cell reactions to SARS-CoV-2) continues for about 5 months (median about 3 months). On the other hand, in SARS-CoV-2 unexposed donors, there was no immune reaction to SARS-CoV-2 spike protein, but the CD4+ T-cells specific to SARS-CoV-2 N protein were observed in 66% of the donors. In SARS-CoV-2 exposed patients, the CD4+ T-cells targeted SARS-CoV-2 spike protein rather than SARS-CoV-2 N protein.<br \/>\nWhether the cross-reactive CD4+ T cells are contributing to suppressing SARS-CoV-2 infection and further less severe outcome needs to be addressed in the prospective cohort before and after COVID-19.<\/p>\n<p><a href=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/03\/immune-memory_SARS-CoV-2-infected-and-uninfected.png\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/03\/immune-memory_SARS-CoV-2-infected-and-uninfected.png\" alt=\"\" width=\"365\" height=\"400\" class=\"alignleft size-full wp-image-3047\" srcset=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/03\/immune-memory_SARS-CoV-2-infected-and-uninfected.png 365w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/03\/immune-memory_SARS-CoV-2-infected-and-uninfected-274x300.png 274w\" sizes=\"auto, (max-width: 365px) 100vw, 365px\" \/><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>A group from National Institute of Immunology, New Delhi, etc. has reported on immune memory (CD4+T-cell react<\/p><\/div>\n<div class=\"blog-btn\"><a href=\"https:\/\/www.emukk.com\/WP\/en\/immune-memory-cd4t-cell-reaction-in-mild-covid-19-patients-and\/\" class=\"home-blog-btn\">\u7d9a\u304d\u3092\u8aad\u3080<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[70],"tags":[],"class_list":["post-3064","post","type-post","status-publish","format-standard","hentry","category-nature-en"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/3064","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/comments?post=3064"}],"version-history":[{"count":2,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/3064\/revisions"}],"predecessor-version":[{"id":3066,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/3064\/revisions\/3066"}],"wp:attachment":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/media?parent=3064"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/categories?post=3064"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/tags?post=3064"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}