{"id":3037,"date":"2021-03-24T19:56:12","date_gmt":"2021-03-24T10:56:12","guid":{"rendered":"http:\/\/www.emukk.com\/WP\/?p=3023"},"modified":"2021-03-24T20:41:59","modified_gmt":"2021-03-24T11:41:59","slug":"cell-surface-n-glycan-of-candida-albicans-mannose-core-works-anti-inflammatory-in-sepsis","status":"publish","type":"post","link":"https:\/\/www.emukk.com\/WP\/en\/cell-surface-n-glycan-of-candida-albicans-mannose-core-works-anti-inflammatory-in-sepsis\/","title":{"rendered":"Cell surface N-glycan of Candida albicans  (mannose core) works anti-inflammatory in sepsis"},"content":{"rendered":"<p>A group from Kyoto University has reported that the cell surface N-glycan (mannose core) of Candida albicans works anti-inflammatory in sepsis.<br \/>\n<a href=\"https:\/\/www.nature.com\/articles\/s42003-021-01870-3\">https:\/\/www.nature.com\/articles\/s42003-021-01870-3<\/a><\/p>\n<p>Sepsis was induced by lipopolysaccharide\uff08LPS\uff09in mouse, and it was demonstrated that purified mannoprotein of Candida albicans stratn J-1020 works anti-inflammatory. Injection of the extracted mannoprotein from J-1020 improved survival greatly. It was found that anti-inflammatory cytokine IL-10 was up-regulated by the injection of J-1020 at this time. It was also confirmed that these phenomena were induced by the interaction between mannoprotein of J-1020 and C-type lectin Dectin-2. When Dectin-2 was knocked out, the survival decreased greatly, and J-1012 mannoprotein did not affect IL-10 production. Further, it was suggested the mannose core of Candida albicans N-glycan is recognized by Dectin-2, leading to suppression of the early onset of septic responses.<\/p>\n<p><a href=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/03\/C.-albicans_LPS_Dectin-2.png\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/03\/C.-albicans_LPS_Dectin-2.png\" alt=\"\" width=\"853\" height=\"510\" class=\"alignleft size-full wp-image-3029\" srcset=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/03\/C.-albicans_LPS_Dectin-2.png 853w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/03\/C.-albicans_LPS_Dectin-2-600x359.png 600w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/03\/C.-albicans_LPS_Dectin-2-300x179.png 300w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/03\/C.-albicans_LPS_Dectin-2-768x459.png 768w\" sizes=\"auto, (max-width: 853px) 100vw, 853px\" \/><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>A group from Kyoto University has reported that the cell surface N-glycan (mannose core) of Candida albicans w<\/p><\/div>\n<div class=\"blog-btn\"><a href=\"https:\/\/www.emukk.com\/WP\/en\/cell-surface-n-glycan-of-candida-albicans-mannose-core-works-anti-inflammatory-in-sepsis\/\" class=\"home-blog-btn\">\u7d9a\u304d\u3092\u8aad\u3080<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[70],"tags":[],"class_list":["post-3037","post","type-post","status-publish","format-standard","hentry","category-nature-en"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/3037","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/comments?post=3037"}],"version-history":[{"count":2,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/3037\/revisions"}],"predecessor-version":[{"id":3039,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/3037\/revisions\/3039"}],"wp:attachment":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/media?parent=3037"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/categories?post=3037"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/tags?post=3037"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}