{"id":2942,"date":"2021-03-17T10:34:09","date_gmt":"2021-03-17T01:34:09","guid":{"rendered":"http:\/\/www.emukk.com\/WP\/?p=2942"},"modified":"2021-07-21T23:24:18","modified_gmt":"2021-07-21T14:24:18","slug":"%e8%86%b5%e7%ae%a1%e8%85%ba%e7%99%8c%e3%81%ab%e3%81%8a%e3%81%91%e3%82%8b%e3%82%b7%e3%82%a2%e3%83%ab%e9%85%b8%e3%81%ae%e7%99%ba%e7%8f%be%e3%81%a8siglec-7-siglec-9%e3%82%92%e4%bb%8b%e3%81%97%e3%81%a6","status":"publish","type":"post","link":"https:\/\/www.emukk.com\/WP\/%e8%86%b5%e7%ae%a1%e8%85%ba%e7%99%8c%e3%81%ab%e3%81%8a%e3%81%91%e3%82%8b%e3%82%b7%e3%82%a2%e3%83%ab%e9%85%b8%e3%81%ae%e7%99%ba%e7%8f%be%e3%81%a8siglec-7-siglec-9%e3%82%92%e4%bb%8b%e3%81%97%e3%81%a6\/","title":{"rendered":"\u81b5\u7ba1\u817a\u764c\u306b\u304a\u3051\u308b\u30b7\u30a2\u30eb\u9178\u306e\u767a\u73fe\u3068Siglec-7, Siglec-9\u3092\u4ecb\u3057\u3066\u306e\u514d\u75ab\u53cd\u5fdc\u6291\u5236"},"content":{"rendered":"<p>Amsterdam UMC\u3089\u306e\u30b0\u30eb\u30fc\u30d7\u306f\u3001\u81b5\u7ba1\u817a\u764c\u3067\u767a\u751f\u3059\u308b\u7570\u5e38\u306a\u7cd6\u9396\u4fee\u98fe\u3001\u3068\u308a\u308f\u3051\u30b7\u30a2\u30eb\u9178\u4fee\u98fe\u306b\u7740\u76ee\u3057\u3001\u81b5\u7ba1\u817a\u764c\u306e\u514d\u75ab\u53cd\u5fdc\u306e\u6291\u5236\u30e1\u30ab\u30cb\u30ba\u30e0\u306b\u3064\u3044\u3066\u7814\u7a76\u3057\u3066\u3044\u307e\u3059\u3002<br \/>\n<a href=\"https:\/\/www.nature.com\/articles\/s41467-021-21550-4.pdf\">https:\/\/www.nature.com\/articles\/s41467-021-21550-4.pdf<\/a><\/p>\n<p>\u81b5\u7ba1\u817a\u764c\u306e\u5468\u8fba\u306b\u306f\u3001\u7dda\u7dad\u6027\u9593\u8cea\u7d30\u80de\u3068\u514d\u75ab\u53cd\u5fdc\u6291\u5236\u7684\u306a\u9aa8\u9ac4\u7cfb\u7d30\u80de\u7fa4\uff08\u6a39\u72b6\u7d30\u80de\u3001\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8\u306a\u3069\uff09\u304c\u5b58\u5728\u3057\u3066\u3044\u307e\u3059\uff08TME\u3068\u547c\u3070\u308c\u308b\uff09\u3002\u81b5\u7ba1\u817a\u764c\u3067\u767a\u751f\u3059\u308b\u7cd6\u9396\u4fee\u98fe\u7570\u5e38\u306b\u3064\u3044\u3066\u306f\u3001Syalyl LewisA, Sialyl LewisX, O\u578b\u7cd6\u9396\u306e\u5208\u8fbc\u3001\u591a\u5206\u5c90N\u578b\u7cd6\u9396\u3068\u30d5\u30b3\u30fc\u30b9\u4fee\u98fe\u3089\u306e\u767a\u73fe\u304c\u4e0a\u6607\u3057\u3001\u764c\u306e\u5897\u6b96\u3084\u6d78\u6f64\u3068\u76f8\u95a2\u95a2\u4fc2\u304c\u3042\u308b\u3053\u3068\u306f\u65e2\u306b\u6307\u6458\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u3057\u304b\u3057\u306a\u304c\u3089\u3001\u3053\u308c\u3089\u306e\u7cd6\u9396\u4fee\u98fe\u306e\u5909\u5316\u3068\u514d\u75ab\u7d30\u80de\u3068\u306e\u30ea\u30f3\u30af\u306b\u3064\u3044\u3066\u306f\u4e0d\u660e\u306a\u70b9\u304c\u591a\u3005\u6b8b\u3063\u3066\u3044\u307e\u3059\u3002<br \/>\n\u8457\u8005\u3089\u306f\u3001\u764c\u3067\u3057\u3070\u3057\u3070\u307f\u3089\u308c\u308b\u03b12-3 Sia\u4fee\u98fe\u306e\u9ad8\u767a\u73fe\u306b\u7740\u76ee\u3057\u3001\u514d\u75ab\u7d30\u80de\u7fa4\u3068\u306e\u30ea\u30f3\u30af\u3001\u304a\u3088\u3073\u81b5\u7ba1\u817a\u764c\u306e\u75c5\u614b\u3068\u306e\u95a2\u4fc2\u6027\u3092\u6df1\u5800\u3057\u3066\u3044\u307e\u3059\u3002TMA\u3092\u69cb\u6210\u3059\u308b\u9aa8\u9ac4\u7cfb\u7d30\u80de\u7fa4\u306e\u69cb\u6210\u306f\u3001\u5065\u5e38\u7d44\u7e54\u3068\u81b5\u7ba1\u817a\u764c\u3067\u306f\u5927\u304d\u304f\u7570\u306a\u3063\u3066\u304a\u308a\u3001\u81b5\u7ba1\u817a\u764c\u3067\u306f\u3001\u5358\u7403\u7531\u6765\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8 (moMac), \u5358\u7403\u7531\u6765\u6a39\u72b6\u7d30\u80de (moDC)\u304c\u5927\u534a\u3092\u5360\u3081\u3066\u3044\u307e\u3059\u3002\u3057\u304b\u3082\u3001moMac\u304cmoDC\u306b\u6bd4\u3079\u3066\u5897\u52a0\u3059\u308b\u3068\u81b5\u7ba1\u817a\u764c\u306e\u751f\u5b58\u7387\u304c\u4f4e\u4e0b\u3057\u3001\u4ed6\u306e\u9aa8\u9ac4\u7cfb\u7d30\u80de\u7fa4\u306f\u751f\u5b58\u7387\u3068\u76f8\u95a2\u3092\u793a\u3055\u306a\u3044\u3053\u3068\u304c\u5206\u304b\u308a\u307e\u3057\u305f\u3002<br \/>\n\u9ad8\u767a\u73fe\u3057\u305f\u03b12-3Sia\u306f\u3001\u9aa8\u9ac4\u7cfb\u7d30\u80de\u7fa4\u306b\u767a\u73fe\u3057\u3066\u3044\u308bSiglec-7, Siglec-9\u3068\u7d50\u5408\u3057\u3001CD206\u306e\u767a\u73fe\u4e0a\u6607\u3068\u3068\u3082\u306b\u3001\u5358\u7403\u306emoMac\u3078\u306e\u5206\u5316\u3092\u4fc3\u9032\u3059\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u307e\u3057\u305f\u3002\u66f4\u306b\u3001\u3053\u306e\u5909\u5316\u306f\u3001\u514d\u75ab\u6291\u5236\u7684\u306b\u6a5f\u80fd\u3059\u308b\u514d\u75ab\u30c1\u30a7\u30c3\u30af\u30dd\u30a4\u30f3\u30c8\u5206\u5b50\u3067\u3042\u308bPD-L1\u306e\u767a\u73fe\u4e0a\u6607\u3084\u514d\u75ab\u6291\u5236\u7684\u306a\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\uff08IL-10\uff09\u306e\u5206\u6ccc\u3092\u4fc3\u3059\u3053\u3068\u3082\u793a\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n<p><a href=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/03\/moMAC_PDAC.png\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/03\/moMAC_PDAC-300x211.png\" alt=\"\" width=\"300\" height=\"211\" class=\"alignleft size-medium wp-image-2947\" srcset=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/03\/moMAC_PDAC-300x211.png 300w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/03\/moMAC_PDAC-600x422.png 600w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/03\/moMAC_PDAC-768x540.png 768w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/03\/moMAC_PDAC.png 891w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><br \/>\n<a href=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/03\/Myeloid-cell-population_PDAC.png\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/03\/Myeloid-cell-population_PDAC-300x181.png\" alt=\"\" width=\"300\" height=\"181\" class=\"alignleft size-medium wp-image-2948\" srcset=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/03\/Myeloid-cell-population_PDAC-300x181.png 300w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/03\/Myeloid-cell-population_PDAC-600x361.png 600w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/03\/Myeloid-cell-population_PDAC-768x462.png 768w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/03\/Myeloid-cell-population_PDAC.png 784w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Amsterdam UMC\u3089\u306e\u30b0\u30eb\u30fc\u30d7\u306f\u3001\u81b5\u7ba1\u817a\u764c\u3067\u767a\u751f\u3059\u308b\u7570\u5e38\u306a\u7cd6\u9396\u4fee\u98fe\u3001\u3068\u308a\u308f\u3051\u30b7\u30a2\u30eb\u9178\u4fee\u98fe\u306b\u7740\u76ee\u3057\u3001\u81b5\u7ba1\u817a\u764c\u306e\u514d\u75ab\u53cd\u5fdc\u306e\u6291\u5236\u30e1\u30ab\u30cb\u30ba\u30e0\u306b\u3064\u3044\u3066\u7814\u7a76\u3057\u3066\u3044\u307e\u3059\u3002 https:\/\/www.nature.com\/arti<\/p><\/div>\n<div class=\"blog-btn\"><a href=\"https:\/\/www.emukk.com\/WP\/%e8%86%b5%e7%ae%a1%e8%85%ba%e7%99%8c%e3%81%ab%e3%81%8a%e3%81%91%e3%82%8b%e3%82%b7%e3%82%a2%e3%83%ab%e9%85%b8%e3%81%ae%e7%99%ba%e7%8f%be%e3%81%a8siglec-7-siglec-9%e3%82%92%e4%bb%8b%e3%81%97%e3%81%a6\/\" class=\"home-blog-btn\">\u7d9a\u304d\u3092\u8aad\u3080<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[642],"tags":[],"class_list":["post-2942","post","type-post","status-publish","format-standard","hentry","category-nature-ja"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/2942","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/comments?post=2942"}],"version-history":[{"count":8,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/2942\/revisions"}],"predecessor-version":[{"id":5121,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/2942\/revisions\/5121"}],"wp:attachment":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/media?parent=2942"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/categories?post=2942"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/tags?post=2942"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}