{"id":2909,"date":"2021-03-14T07:49:55","date_gmt":"2021-03-13T22:49:55","guid":{"rendered":"http:\/\/www.emukk.com\/WP\/?p=2904"},"modified":"2021-03-15T06:53:45","modified_gmt":"2021-03-14T21:53:45","slug":"a-counter-receptor-of-siglec-7-was-identified-as-leukosialin-cd43","status":"publish","type":"post","link":"https:\/\/www.emukk.com\/WP\/en\/a-counter-receptor-of-siglec-7-was-identified-as-leukosialin-cd43\/","title":{"rendered":"A counter-receptor of Siglec-7 was identified as \u00a0leukosialin (CD43)"},"content":{"rendered":"<p>A group from Nagoya Univ. has identified a counter-receptor of Siglec-7.<br \/>\n<a href=\"https:\/\/www.jbc.org\/article\/S0021-9258(21)00251-9\/fulltext\">https:\/\/www.jbc.org\/article\/S0021-9258(21)00251-9\/fulltext<\/a><\/p>\n<p>Siglec-7 binds to sialic acids and are expressed on natural killer (NK) cells and monocytes. Siglec-7 suppress cytotoxicity of NK cells through interaction with a counter-receptor on it. However, the counter-receptor of Siglec-7 has not been identified yet completely. Authors purified the receptor with using K562 cells, FC-Siglec-7 fusion protein, diSia-dextran polymer, and identified it as leukosialin (CD43) with MS analysis. Additionally, they demonstrated that the cytotoxicity of NK cells toward K562 cells was suppressed by overexpression of leukosialin in a Siglec-7-dependent manner.<br \/>\n\u00a0<\/p>\n","protected":false},"excerpt":{"rendered":"<p>A group from Nagoya Univ. has identified a counter-receptor of Siglec-7. https:\/\/www.jbc.org\/article\/S0021-925<\/p><\/div>\n<div class=\"blog-btn\"><a href=\"https:\/\/www.emukk.com\/WP\/en\/a-counter-receptor-of-siglec-7-was-identified-as-leukosialin-cd43\/\" class=\"home-blog-btn\">\u7d9a\u304d\u3092\u8aad\u3080<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[70],"tags":[],"class_list":["post-2909","post","type-post","status-publish","format-standard","hentry","category-nature-en"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/2909","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/comments?post=2909"}],"version-history":[{"count":3,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/2909\/revisions"}],"predecessor-version":[{"id":2912,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/2909\/revisions\/2912"}],"wp:attachment":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/media?parent=2909"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/categories?post=2909"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/tags?post=2909"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}