{"id":2861,"date":"2021-03-12T08:41:12","date_gmt":"2021-03-11T23:41:12","guid":{"rendered":"http:\/\/www.emukk.com\/WP\/?p=2861"},"modified":"2021-07-21T23:25:57","modified_gmt":"2021-07-21T14:25:57","slug":"q677%e5%a4%89%e7%95%b0%ef%bc%88q677h-q677p%ef%bc%89%e3%81%ae%e3%82%a6%e3%82%a4%e3%83%ab%e3%82%b9%e6%84%9f%e6%9f%93%e5%8a%9b%e3%81%ab%e5%af%be%e3%81%99%e3%82%8b%e5%bd%b1%e9%9f%bf%e3%81%ab%e3%81%a4","status":"publish","type":"post","link":"https:\/\/www.emukk.com\/WP\/q677%e5%a4%89%e7%95%b0%ef%bc%88q677h-q677p%ef%bc%89%e3%81%ae%e3%82%a6%e3%82%a4%e3%83%ab%e3%82%b9%e6%84%9f%e6%9f%93%e5%8a%9b%e3%81%ab%e5%af%be%e3%81%99%e3%82%8b%e5%bd%b1%e9%9f%bf%e3%81%ab%e3%81%a4\/","title":{"rendered":"Q677\u5909\u7570\uff08Q677H, Q677P\uff09\u306e\u30a6\u30a4\u30eb\u30b9\u611f\u67d3\u529b\u306b\u5bfe\u3059\u308b\u5f71\u97ff\u306b\u3064\u3044\u3066\uff1aRRAR Motif\u5468\u8fba\u306e\u69cb\u9020\u5909\u5316\u304b\u3089"},"content":{"rendered":"

2021\u5e742\u670819\u65e5\u306e\u30d6\u30ed\u30b0\u306b\u3066\u3001Q677H, Q677P\u3068\u3044\u3046\u5909\u7570\u304c\u6628\u5e74\u672b\u304b\u3089\u5317\u7c73\u3067\u4e0a\u6607\u3057\u3066\u3044\u308b\u3053\u3068\u3092\u7d39\u4ecb\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n

Univ. of Bern\u3089\u306e\u30b0\u30eb\u30fc\u30d7\u306f\u3001Q677\u5909\u7570\u304cSARS-CoV-2\u611f\u67d3\u306b\u4e0e\u3048\u308b\u5f71\u97ff\u306b\u3064\u3044\u3066\u3001SWISS MODEL\u3092\u4f7f\u3063\u3066\u8b70\u8ad6\u3057\u3066\u3044\u307e\u3059\u3002
\nhttps:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7885944\/<\/a><\/p>\n

S1\/S2\u5207\u65ad\u90e8\u4f4d\u306b\u306f\u591a\u5869\u57fa\u5207\u65ad\u90e8\u4f4d\uff08RRAR Motif\uff09\u304c\u5b58\u5728\u3057\u307e\u3059\u3002\u4f4d\u7f6e677\u306f\u591a\u5869\u57fa\u90e8\u4f4d\uff08furin binding pocket\uff09\u306e\u5916\u5074\u306b\u3042\u308a\u307e\u3059\u304c\u3001\u3053\u306e\u90e8\u4f4d\u306b\u30d7\u30ed\u30ea\u30f3\u304c\u5b58\u5728\u3059\u308b\u3068\u3001 S1\/S2\u63a5\u5408\u90e8\u3067\u306e\u5207\u65ad\u306b\u6709\u5229\u306b\u50cd\u304f\u69cb\u9020\u5909\u5316\u3092\u5f15\u304d\u8d77\u3053\u3059\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\u3053\u306e\u5207\u65ad\u306f\u3001\u30d5\u30e5\u30fc\u30ea\u30f3\u69d8\u6d3b\u6027\u3060\u3051\u3067\u306a\u304f\u3001\u30c8\u30ea\u30d7\u30b7\u30f3\u69d8\u30d7\u30ed\u30c6\u30a2\u30fc\u30bc\uff08TMPRSS2\u306a\u3069\uff09\u304a\u3088\u3073\u30ab\u30c6\u30d7\u30b7\u30f3\u306b\u3088\u3063\u3066\u3082\u652f\u914d\u3055\u308c\u307e\u3059\u3002\u3055\u3089\u306b\u3001\u30d7\u30ed\u30ea\u30f3\u306e\u5c0e\u5165\u306f\u3001S689\u306e\u70ad\u7d20\u9aa8\u683c\u304b\u30893.7\u30aa\u30f3\u30b0\u30b9\u30c8\u30ed\u30fc\u30e0\u96e2\u308c\u3066\u3044\u308b\u3088\u3046\u306b\u898b\u3048\u307e\u3059\uff08\u30cd\u30a4\u30c6\u30a3\u30d6\u30b0\u30eb\u30bf\u30df\u30f3\u306e4.9\u30aa\u30f3\u30b0\u30b9\u30c8\u30ed\u30fc\u30e0\u3068\u6bd4\u8f03\u3057\u3066\uff09\u3002\u3053\u308c\u306f\u3001\u30bf\u30f3\u30d1\u30af\u8cea\u5206\u89e3\u5207\u65ad\u306b\u6709\u5229\u306a\u30b3\u30f3\u30d5\u30a9\u30e1\u30fc\u30b7\u30e7\u30f3\u3092\u4fc3\u9032\u3059\u308b\u539f\u5b50\u76f8\u4e92\u4f5c\u7528\u3092\u4fc3\u9032\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002S\uff1aQ677H\u7f6e\u63db\u306e\u5834\u5408\u3001\u30d2\u30b9\u30c1\u30b8\u30f3\u306e\u30d7\u30ed\u30c8\u30f3\u5316\u306f\u3001\u30d7\u30ed\u30c6\u30a2\u30fc\u30bc\u3078\u306e\u30a2\u30af\u30bb\u30b9\u53ef\u80fd\u6027\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u30b3\u30f3\u30d5\u30a9\u30e1\u30fc\u30b7\u30e7\u30f3\u30b9\u30a4\u30c3\u30c1\u3068\u3057\u3066\u540c\u69d8\u306b\u6a5f\u80fd\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\u3053\u308c\u3089\u306e\u69cb\u9020\u5909\u5316\u306f\u3001\u3088\u308a\u52b9\u7387\u7684\u306a\u30a6\u30a4\u30eb\u30b9\u4fb5\u5165\u3092\u4fc3\u9032\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n

\"\"<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

2021\u5e742\u670819\u65e5\u306e\u30d6\u30ed\u30b0\u306b\u3066\u3001Q677H, Q677P\u3068\u3044\u3046\u5909\u7570\u304c\u6628\u5e74\u672b\u304b\u3089\u5317\u7c73\u3067\u4e0a\u6607\u3057\u3066\u3044\u308b\u3053\u3068\u3092\u7d39\u4ecb\u3057\u3066\u3044\u307e\u3059\u3002 Univ. of Bern\u3089\u306e\u30b0\u30eb\u30fc\u30d7\u306f\u3001Q677\u5909\u7570\u304cSARS-CoV-2\u611f\u67d3\u306b\u4e0e\u3048\u308b\u5f71\u97ff\u306b\u3064\u3044<\/p><\/div>\n

\u7d9a\u304d\u3092\u8aad\u3080<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[642],"tags":[],"class_list":["post-2861","post","type-post","status-publish","format-standard","hentry","category-nature-ja"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/2861","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/comments?post=2861"}],"version-history":[{"count":5,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/2861\/revisions"}],"predecessor-version":[{"id":5125,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/2861\/revisions\/5125"}],"wp:attachment":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/media?parent=2861"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/categories?post=2861"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/tags?post=2861"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}