{"id":2823,"date":"2021-03-10T11:02:31","date_gmt":"2021-03-10T02:02:31","guid":{"rendered":"http:\/\/www.emukk.com\/WP\/?p=2817"},"modified":"2021-03-10T12:47:27","modified_gmt":"2021-03-10T03:47:27","slug":"monochronal-antibody-cocktails-would-be-effective-in-rapidly-mutating-rna-viruses-such-as-sars-cov-2","status":"publish","type":"post","link":"https:\/\/www.emukk.com\/WP\/en\/monochronal-antibody-cocktails-would-be-effective-in-rapidly-mutating-rna-viruses-such-as-sars-cov-2\/","title":{"rendered":"Monochronal Antibody Cocktails would be effective in rapidly mutating RNA viruses such as SARS-CoV-2\u00a0"},"content":{"rendered":"<p>A group from Fred Hutchinson Cancer Research Center, etc. has investigated the effect of genomic mutations onto two types of monochronal antibodies (LY-CoV555 and LY-CoV016) against RBD of SARS-CoV-2.<br \/>\n<a href=\"https:\/\/www.biorxiv.org\/content\/10.1101\/2021.02.17.431683v1\">https:\/\/www.biorxiv.org\/content\/10.1101\/2021.02.17.431683v1<\/a><\/p>\n<p>It was found that LY-CoV016 is very weak for K417N mutation, and LY-CoV555 is so weak for E484K mutation. In both cases, IC<sub>50<\/sub> increased more than 1,000 times with these mutations. Therefore, a strategy using antibody cocktails with different monochronal antibodies with different target epitopes would be quite effective in developing therapeutic drugs for rapidly mutating RNA viruses such as SARS-CoV-2.<\/p>\n<p><a href=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/03\/cocktail_mAbs.png\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-full wp-image-2821\" src=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/03\/cocktail_mAbs.png\" alt=\"\" width=\"257\" height=\"158\" \/><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>A group from Fred Hutchinson Cancer Research Center, etc. has investigated the effect of genomic mutations ont<\/p><\/div>\n<div class=\"blog-btn\"><a href=\"https:\/\/www.emukk.com\/WP\/en\/monochronal-antibody-cocktails-would-be-effective-in-rapidly-mutating-rna-viruses-such-as-sars-cov-2\/\" class=\"home-blog-btn\">\u7d9a\u304d\u3092\u8aad\u3080<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[7],"tags":[],"class_list":["post-2823","post","type-post","status-publish","format-standard","hentry","category-technology-en"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/2823","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/comments?post=2823"}],"version-history":[{"count":3,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/2823\/revisions"}],"predecessor-version":[{"id":2829,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/2823\/revisions\/2829"}],"wp:attachment":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/media?parent=2823"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/categories?post=2823"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/tags?post=2823"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}