{"id":2711,"date":"2021-03-05T10:43:14","date_gmt":"2021-03-05T01:43:14","guid":{"rendered":"http:\/\/www.emukk.com\/WP\/?p=2711"},"modified":"2021-07-21T23:28:01","modified_gmt":"2021-07-21T14:28:01","slug":"core2-gnt-o%e5%9e%8b%e7%b3%96%e9%8e%96-core2-glcnac%e8%bb%a2%e7%a7%bb%e9%85%b5%e7%b4%a0%ef%bc%89%e3%81%ae%e9%98%bb%e5%ae%b3%e3%81%8c%e7%b5%a8%e6%af%9b%e7%99%8c%e3%81%ae%e6%b2%bb%e7%99%82%e3%81%ab","status":"publish","type":"post","link":"https:\/\/www.emukk.com\/WP\/core2-gnt-o%e5%9e%8b%e7%b3%96%e9%8e%96-core2-glcnac%e8%bb%a2%e7%a7%bb%e9%85%b5%e7%b4%a0%ef%bc%89%e3%81%ae%e9%98%bb%e5%ae%b3%e3%81%8c%e7%b5%a8%e6%af%9b%e7%99%8c%e3%81%ae%e6%b2%bb%e7%99%82%e3%81%ab\/","title":{"rendered":"Core2 GnT (O\u578b\u7cd6\u9396 Core2 GlcNAc\u8ee2\u79fb\u9175\u7d20\uff09\u306e\u963b\u5bb3\u304c\u7d68\u6bdb\u764c\u306e\u6cbb\u7642\u306b\u6709\u52b9"},"content":{"rendered":"

\u540d\u5927\u533b\u5b66\u90e8\u306e\u30b0\u30eb\u30fc\u30d7\u306f\u3001C2GnT (O\u578b\u7cd6\u9396 Core2 GlcNAc\u8ee2\u79fb\u9175\u7d20\uff09\u306e\u963b\u5bb3\u5264\u304c\u7d68\u6bdb\u764c\u306e\u6cbb\u7642\u306b\u6709\u52b9\u3067\u3042\u308b\u3053\u3068\u3092\u5831\u544a\u3057\u3066\u3044\u307e\u3059\u3002
\nhttps:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7895715\/<\/a><\/p>\n

\u7d68\u6bdb\u764c\u306f\u3001\u5973\u6027\u7279\u6709\u306e\u75c5\u6c17\u306b\u3066\u3001\u598a\u5a20\u6642\u306e\u80ce\u76e4\u3092\u3064\u304f\u308b\u7d68\u6bdb\u7d30\u80de\uff08\u30c8\u30ed\u30db\u30d6\u30e9\u30b9\u30c8\uff09\u306b\u767a\u751f\u3059\u308b\u60aa\u6027\u816b\u760d\u3067\u3059\u3002<\/p>\n

NK\u7d30\u80de\u306e\u8868\u9762\u306b\u306fNKG2D\u3068\u3044\u3046\u53d7\u5bb9\u4f53\u304c\u3042\u308a\u3001\u816b\u760d\u306b\u3057\u3070\u3057\u3070\u5b58\u5728\u3059\u308b\u30af\u30e9\u30b9I\u9396\u95a2\u9023\u30bf\u30f3\u30d1\u30af\u8ceaA\uff08MICA\uff09\u3068\u7d50\u5408\u3059\u308b\u3053\u3068\u3067\u3001NK\u7d30\u80de\u306e\u7d30\u80de\u969c\u5bb3\u6d3b\u6027\u304c\u5f15\u304d\u51fa\u3055\u308c\u308b\u3068\u5f93\u6765\u3088\u308a\u8003\u3048\u3089\u308c\u3066\u304d\u307e\u3057\u305f\u3002<\/p>\n

\u4e0b\u56f3\u306b\u793a\u3059\u3088\u3046\u306b\u3001LEL\u30ec\u30af\u30c1\u30f3\u3067IP\u3057\u305fMICA\u306f\u3001C2GnT\u3092KO\u3059\u308b\u3053\u3068\u3067\u660e\u3089\u304b\u306b\u6e1b\u5c11\u3059\u308b\u3053\u3068\u304b\u3089\u3001MICA\u306fpoly lactosamine\u69cb\u9020\u3092\u6301\u3064Core2 O\u578b\u7cd6\u9396\u4fee\u98fe\u3092\u53d7\u3051\u3066\u3044\u308b\u3053\u3068\u304c\u5206\u304b\u308a\u307e\u3059\u3002C2GnT\u3092KO\u3059\u308b\u3053\u3068\u3067\u3001\u5f53\u7136\u306a\u304c\u3089poly lactosamin\u306e\u4f38\u9577\u306f\u8d77\u3053\u3089\u306a\u304f\u306a\u308a\u307e\u3059\u3002Jar\u3068BeWo\u306f\u7d68\u6bdb\u764c\u7d30\u80de\u682a\u3067\u3042\u308a\u3001NK\u7d30\u80de\u6bd2\u6027\u306b\u5bfe\u3057\u3066\u3001C2GnT\u3092KO\u3057\u305f\u7d30\u80de\u3068control\u3092\u6bd4\u8f03\u3057\u305f\u7d50\u679c\u306f\u3001\u660e\u3089\u304b\u306bC2GnT\u306eKO\u3067NK\u7d30\u80de\u969c\u5bb3\u6d3b\u6027\u304c\u4e0a\u6607\u3059\u308b\u3053\u3068\u3092\u793a\u3057\u3066\u3044\u307e\u3059\u3002\u307e\u305f\u3001\u30a8\u30f3\u30c9\u2010\u03b2\u2010\u30ac\u30e9\u30af\u30c8\u30b7\u30c0\u30fc\u30bc\u306e\u51e6\u7406\u306f\u3001poly lactosamine\u306e\u69cb\u9020\u3092\u5207\u65ad\u3057\u3066\u3057\u307e\u3044\u307e\u3059\u306e\u3067\u3001C2GnT KO\u3068\u540c\u3058\u3088\u3046\u306bNK\u7d30\u80de\u969c\u5bb3\u6d3b\u6027\u3092\u4fc3\u3057\u307e\u3059\u3002
\n\u3064\u307e\u308a\u3001\u3053\u308c\u3089\u306e\u7d50\u679c\u306f\u3001MICA\u306epoly lactosamine\u4fee\u98fe\u304cNK\u7d30\u80de\u6bd2\u6027\u3092\u62bc\u3055\u3048\u3066\u3044\u308b\u3053\u3068\u3092\u793a\u3057\u3066\u304a\u308a\u3001C2GnT\u304c\u9ad8\u767a\u73fe\u3059\u308b\u307b\u3069\u3001\u7d68\u6bdb\u764c\u304c\u514d\u75ab\u3092\u56de\u907f\u3057\u3066\u3057\u307e\u3046\u3053\u3068\u3092\u793a\u3057\u3066\u3044\u307e\u3059\u3002\u3059\u306a\u308f\u3061\u3001\u3053\u306e\u963b\u5bb3\u304c\u7d68\u6bdb\u764c\u306e\u6cbb\u7642\u6cd5\u306b\u7d50\u3073\u4ed8\u304f\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n

\"\"<\/a>\"\"<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

\u540d\u5927\u533b\u5b66\u90e8\u306e\u30b0\u30eb\u30fc\u30d7\u306f\u3001C2GnT (O\u578b\u7cd6\u9396 Core2 GlcNAc\u8ee2\u79fb\u9175\u7d20\uff09\u306e\u963b\u5bb3\u5264\u304c\u7d68\u6bdb\u764c\u306e\u6cbb\u7642\u306b\u6709\u52b9\u3067\u3042\u308b\u3053\u3068\u3092\u5831\u544a\u3057\u3066\u3044\u307e\u3059\u3002 https:\/\/www.ncbi.nlm.nih.gov\/pmc\/article<\/p><\/div>\n

\u7d9a\u304d\u3092\u8aad\u3080<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[642],"tags":[],"class_list":["post-2711","post","type-post","status-publish","format-standard","hentry","category-nature-ja"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/2711","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/comments?post=2711"}],"version-history":[{"count":10,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/2711\/revisions"}],"predecessor-version":[{"id":5130,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/2711\/revisions\/5130"}],"wp:attachment":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/media?parent=2711"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/categories?post=2711"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/tags?post=2711"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}