{"id":2641,"date":"2021-03-01T06:00:31","date_gmt":"2021-02-28T21:00:31","guid":{"rendered":"http:\/\/www.emukk.com\/WP\/?p=2570"},"modified":"2021-03-01T06:40:57","modified_gmt":"2021-02-28T21:40:57","slug":"c-type-lectins-cd209-dc-sign-cd209l-l-sign-could-be-infection-receptors","status":"publish","type":"post","link":"https:\/\/www.emukk.com\/WP\/en\/c-type-lectins-cd209-dc-sign-cd209l-l-sign-could-be-infection-receptors\/","title":{"rendered":"Once again: C-type Lectins, CD209\/DC-SIGN, CD209L\/L-SIGN, could be infection receptors of SARS-CoV-2 as well as ACE2"},"content":{"rendered":"

There have been some papers reporting that C-type Lectins could be SARS-CoV-2 infection receptors as well as well-know ACE2.
\nHarvard Medical School, July 30, 2020
\nhttps:\/\/www.biorxiv.org\/content\/10.1101\/2020.07.29.227462v1<\/a>
\nBoston University, Dec. 9, 2020
\nhttps:\/\/www.biorxiv.org\/content\/10.1101\/2020.06.22.165803v2<\/a>
\nThere was a review paper from Boston University, (Dec. 22, 2020) in addition to the above paper, let me introduce two kinds of interesting data for your reference.
\nhttps:\/\/www.mdpi.com\/2079-7737\/10\/1\/1<\/a><\/p>\n

Although ACE2 is a really important virus receptor, the expression level of ACE in lung is very low, however, CD209 and CD209L are more broadly expressed in human tissues rather than the ACE2.
\nA result of infection experiments using SAR-CoV-2 pseudotyped lentivirus and HEK293 cells overly expressing CD209L, CD209, and ACE2 is also shown below.
\nTaking these things into consideration, it would be clear that CD209 and CD209L could mediate SARS-CoV-2 entry as infection receptors even for tissues lacking ACE2 expression.
\nThe CRDs of C-type Lectins (DC-SIGN, L-SIGN) recognize strongly high mannose type glycans.<\/p>\n

\"\"<\/a><\/p>\n

\"\"<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

There have been some papers reporting that C-type Lectins could be SARS-CoV-2 infection receptors as well as w<\/p><\/div>\n

\u7d9a\u304d\u3092\u8aad\u3080<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[70],"tags":[],"class_list":["post-2641","post","type-post","status-publish","format-standard","hentry","category-nature-en"],"aioseo_notices":[],"aioseo_head":"\n\t\t\n\t\n\t\n\t\n\t\n\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t