{"id":2616,"date":"2021-03-01T06:05:58","date_gmt":"2021-02-28T21:05:58","guid":{"rendered":"http:\/\/www.emukk.com\/WP\/?p=2616"},"modified":"2021-07-21T23:30:15","modified_gmt":"2021-07-21T14:30:15","slug":"hiv%e3%81%ab%e6%84%9f%e6%9f%93%e3%81%97%e3%81%a6%e3%82%82%e7%84%a1%e7%97%87%e7%8a%b6%e3%81%aa%e5%ad%90%e4%be%9b%e9%81%94%e3%81%aeigg%e3%81%ab%e3%81%af%e3%80%81%e3%81%9d%e3%81%ae%e7%b3%96%e9%8e%96","status":"publish","type":"post","link":"https:\/\/www.emukk.com\/WP\/hiv%e3%81%ab%e6%84%9f%e6%9f%93%e3%81%97%e3%81%a6%e3%82%82%e7%84%a1%e7%97%87%e7%8a%b6%e3%81%aa%e5%ad%90%e4%be%9b%e9%81%94%e3%81%aeigg%e3%81%ab%e3%81%af%e3%80%81%e3%81%9d%e3%81%ae%e7%b3%96%e9%8e%96\/","title":{"rendered":"HIV\u306b\u611f\u67d3\u3057\u3066\u3082\u7121\u75c7\u72b6\u306a\u5b50\u4f9b\u9054\u306eIgG\u306b\u306f\u3001\u305d\u306e\u7cd6\u9396\u4fee\u98fe\u306b\u7279\u5fb4\u304c\u5b58\u5728\u3059\u308b"},"content":{"rendered":"<p>University of Oxford\u3089\u306e\u30b0\u30eb\u30fc\u30d7\u306f\u3001HIV\u306b\u611f\u67d3\u3057\u305f\u5b50\u4f9b\u9054\u306b\u304a\u3051\u308b\u8208\u5473\u6df1\u3044\u514d\u75ab\u53cd\u5fdc\u306b\u3064\u3044\u3066\u5831\u544a\u3057\u3066\u3044\u307e\u3059\u3002<br \/>\n<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7763548\/\">https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7763548\/<\/a><\/p>\n<p>HIV\u306b\u611f\u67d3\u3057\u3066\u3001ART\uff08antiretroviral therapy\uff09\u6cbb\u7642\u3092\u53d7\u3051\u3066\u3082\u304a\u3089\u305a\u3001\u9ad8\u3044\u5272\u5408\u3067\u30a6\u30a4\u30eb\u30b9\u8907\u88fd\u304c\u9032\u884c\u4e2d\u3067\u3042\u308b\u306b\u3082\u304b\u304b\u308f\u3089\u305a\u3001\u6b63\u5e38\u306aCD4\u30ab\u30a6\u30f3\u30c8\u3092\u7dad\u6301\u3059\u308b\u7121\u75c7\u72b6\u306a\u5b50\u4f9b\u9054\uff08PNP\uff09\u304c\u3044\u307e\u3059\u3002\u5b50\u4f9b\u9054\u306b\u304a\u3044\u3066\u306f\u3001\u5e83\u57df\u4e2d\u548c\u6297\u4f53\uff08bnAb\uff09\u306e\u5b58\u5728\u3082\u7279\u5fb4\u3067\u3042\u308a\u307e\u3059\u3002\u66f4\u306b\u3001PNP\u3067\u306f\u3001IgG\u306eFc\u3092\u4ecb\u3057\u305feffector\u4f5c\u7528\uff08ADCC, ADCP\uff09\u304c\u5f37\u3044\u3068\u3044\u3046\u3053\u3068\u3082\u7279\u5fb4\u3067\u3059\u3002<\/p>\n<p>IgG\u306e\u7cd6\u9396\u4fee\u98fe\u306e\u9055\u3044\u306b\u7740\u76ee\u3059\u308b\u3068\u3001HIV\u306b\u611f\u67d3\u3057\u305f\u5927\u4eba\u306f\u4e00\u822c\u7684\u306bagalacto\u578b\u306e\u7cd6\u9396\u69cb\u9020\u3092\u6301\u3064\u306e\u3067\u3059\u304c\u3001\u7121\u75c7\u72b6\u306e\u5b50\u4f9b\u306e\u7cd6\u9396\u306f\u5065\u5e38\u8005\u3068\u5927\u304d\u306a\u9055\u3044\u304c\u306a\u304f\u3001\u3080\u3057\u308dSia\u4fee\u98fe\u304c\u82e5\u5e72\u9ad8\u3081\u3067\u3042\u308a\u3001Fc\u306eCore Fucose\u306e\u4fee\u98fe\u304c\u5c11\u306a\u3044\u3068\u3044\u3046\u7279\u5fb4\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n<p>bnAb\u306f\u3001\u30d8\u30eb\u30d1\u30fcT\u7d30\u80de\uff08Tfh\uff09\u304a\u3088\u3073gp120\u7279\u7570\u7684\u306aIgG\u306eSia\u4fee\u98fe\u3068\u76f8\u95a2\u3057\u3066\u3044\u307e\u3057\u305f\u3002<br \/>\nIgG\u306eFc\u3092\u4ecb\u3057\u305feffector\u52b9\u679c\u306b\u3064\u3044\u3066\u306f\u3001core fucose\u306e\u4fee\u98fe\u304c\u4f4e\u304f\u306a\u308b\u307b\u3069\u3001\u5f37\u304f\u306a\u308b\u3053\u3068\u304c\u6297\u4f53\u533b\u85ac\u3067\u826f\u304f\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n<p>\u3057\u3066\u307f\u308b\u3068PNP\u3068\u3044\u3046\u306e\u306f\u3001\u57fa\u672c\u514d\u75ab\u53cd\u5fdc\u306f\u5f31\u3081\u3067\u306f\u3042\u308b\u304c\u3001\u305d\u308c\u3092\u88dc\u3046bnAb\u304c\u5b58\u5728\u3057\u3001IgG\u306eeffector\u4f5c\u7528\u3082\u5f37\u3044\u3068\u3044\u3046\u3053\u3068\u306a\u306e\u304b\u3082\u77e5\u308c\u307e\u305b\u3093\u3002<br \/>\n<a href=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/02\/HIV_bnAb-4.png\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-medium wp-image-2624\" src=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/02\/HIV_bnAb-4-300x242.png\" alt=\"\" width=\"300\" height=\"242\" srcset=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/02\/HIV_bnAb-4-300x242.png 300w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/02\/HIV_bnAb-4-600x484.png 600w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/02\/HIV_bnAb-4.png 685w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>University of Oxford\u3089\u306e\u30b0\u30eb\u30fc\u30d7\u306f\u3001HIV\u306b\u611f\u67d3\u3057\u305f\u5b50\u4f9b\u9054\u306b\u304a\u3051\u308b\u8208\u5473\u6df1\u3044\u514d\u75ab\u53cd\u5fdc\u306b\u3064\u3044\u3066\u5831\u544a\u3057\u3066\u3044\u307e\u3059\u3002 https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7<\/p><\/div>\n<div class=\"blog-btn\"><a href=\"https:\/\/www.emukk.com\/WP\/hiv%e3%81%ab%e6%84%9f%e6%9f%93%e3%81%97%e3%81%a6%e3%82%82%e7%84%a1%e7%97%87%e7%8a%b6%e3%81%aa%e5%ad%90%e4%be%9b%e9%81%94%e3%81%aeigg%e3%81%ab%e3%81%af%e3%80%81%e3%81%9d%e3%81%ae%e7%b3%96%e9%8e%96\/\" 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