{"id":2595,"date":"2021-03-01T06:02:15","date_gmt":"2021-02-28T21:02:15","guid":{"rendered":"http:\/\/www.emukk.com\/WP\/?p=2595"},"modified":"2021-07-21T23:30:56","modified_gmt":"2021-07-21T14:30:56","slug":"%e8%86%9c%e6%80%a7%e7%b3%b8%e7%90%83%e4%bd%93%e8%85%8e%e7%82%8e%ef%bc%88membranous-nephropathy%ef%bc%89%e3%81%ae%e6%b2%bb%e7%99%82%e3%81%ab%e3%81%af%e3%80%81%e6%8d%95%e4%bd%93%e7%b5%8c%e8%b7%af","status":"publish","type":"post","link":"https:\/\/www.emukk.com\/WP\/%e8%86%9c%e6%80%a7%e7%b3%b8%e7%90%83%e4%bd%93%e8%85%8e%e7%82%8e%ef%bc%88membranous-nephropathy%ef%bc%89%e3%81%ae%e6%b2%bb%e7%99%82%e3%81%ab%e3%81%af%e3%80%81%e6%8d%95%e4%bd%93%e7%b5%8c%e8%b7%af\/","title":{"rendered":"\u819c\u6027\u7cf8\u7403\u4f53\u814e\u708e\uff08Membranous Nephropathy\uff09\u306e\u6cbb\u7642\u306b\u306f\u3001\u6355\u4f53\u7d4c\u8def\u306e\u963b\u5bb3\u304c\u6709\u52b9"},"content":{"rendered":"<p>The Ohio State University Wexner Medical Center\u3089\u306e\u30b0\u30eb\u30fc\u30d7\u306f\u3001\u819c\u6027\u7cf8\u7403\u4f53\u814e\u708e\uff08Membranous Nephropathy\uff1aMN\uff09\u306e\u539f\u56e0\u3068\u306a\u3063\u3066\u3044\u308b\u306e\u304c\u88dc\u4f53\u306e\u904e\u5270\u306a\u84c4\u7a4d\u3067\u3042\u308b\u3053\u3068\u3092\u6307\u6458\u3057\u3066\u307e\u3059\u3002<br \/>\n<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7879111\/pdf\/main.pdf\">https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7879111\/pdf\/main.pdf<\/a><\/p>\n<p>\u814e\u81d3\u7d44\u7e54\u5207\u7247\u304b\u3089LMD\u3067\u30b5\u30f3\u30d7\u30eb\u3092\u53d6\u5f97\u3057\u3001\u8cea\u91cf\u5206\u6790\u306b\u3066\u3001IgG\u53ca\u3073\u88dc\u4f53\u306e\u767a\u73fe\u91cf\u3092\u7db2\u7f85\u7684\u306b\u89e3\u6790\u3057\u307e\u3057\u305f\u3002\u305d\u306e\u7d50\u679c\u3001\u819c\u6027\u7cf8\u7403\u4f53\u814e\u708e\u3067\u306f\u3001IgG1~IgG4\u304a\u3088\u3073CR1\u4ee5\u5916\u306e\u5168\u3066\u306e\u88dc\u4f53\u7fa4\u304c\u5065\u5e38\u8005\u306b\u6bd4\u8f03\u3057\u3066\u9ad8\u767a\u73fe\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u78ba\u8a8d\u3055\u308c\u307e\u3057\u305f\u3002\u4e00\u65b9\u3067\u3001mannose-binding lectin (MBL), Ficolin, Collectin\u3089\u306f\u691c\u51fa\u3055\u308c\u307e\u305b\u3093\u3067\u3057\u305f\u3002\u3053\u308c\u3089\u306e\u7d50\u679c\u306f\u3001\u30ec\u30af\u30c1\u30f3\u7d4c\u8def\u3067\u306f\u306a\u304f\u3001\u88dc\u4f53\u53e4\u5178\u7d4c\u8def\u304c\u7570\u5e38\u306b\u6d3b\u6027\u5316\u3055\u308c\u7cf8\u7403\u4f53\u7d44\u7e54\u306b\u30c0\u30e1\u30fc\u30b8\u3092\u4e0e\u3048\u3066\u3044\u308b\u3053\u3068\u304c\u793a\u5506\u3055\u308c\u307e\u3059\u3002CR1\u306f\u4e3b\u306b\u7cf8\u7403\u4f53\u4e0a\u76ae\u7d30\u80de\uff08podocyte\uff09\u306b\u767a\u73fe\u3057\u3066\u3044\u308b\u3053\u3068\u304b\u3089\u3001\u30c0\u30e1\u30fc\u30b8\u3092\u53d7\u3051\u3066CR1\u304c\u6e1b\u5c11\u3059\u308b\u3053\u3068\u304c\u88dc\u4f53\u306e\u6d3b\u6027\u5316\u3092\u66f4\u306b\u52a0\u901f\u3057\u3066\u3044\u308b\u306e\u304b\u3082\u77e5\u308c\u307e\u305b\u3093\u3002\u306a\u304a\u3001\u819c\u6027\u7cf8\u7403\u4f53\u814e\u708e\u306e\u5834\u5408\u306b\u306f\u3001M-type phospholipase A2 receptor (PLA2R)\u304c\u767a\u75c7\u306e\u6297\u539f\u306b\u306a\u3063\u3066\u3044\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u308b\u3088\u3046\u3067\u3059\u3002<\/p>\n<p><a href=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/02\/glomerular-complement-protein-in-pMN.png\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-medium wp-image-2596\" src=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/02\/glomerular-complement-protein-in-pMN-300x226.png\" alt=\"\" width=\"300\" height=\"226\" srcset=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/02\/glomerular-complement-protein-in-pMN-300x226.png 300w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/02\/glomerular-complement-protein-in-pMN.png 494w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>The Ohio State University Wexner Medical Center\u3089\u306e\u30b0\u30eb\u30fc\u30d7\u306f\u3001\u819c\u6027\u7cf8\u7403\u4f53\u814e\u708e\uff08Membranous Nephropathy\uff1aMN\uff09\u306e\u539f\u56e0\u3068\u306a\u3063\u3066\u3044\u308b\u306e\u304c\u88dc\u4f53\u306e\u904e\u5270\u306a\u84c4\u7a4d\u3067\u3042<\/p><\/div>\n<div class=\"blog-btn\"><a href=\"https:\/\/www.emukk.com\/WP\/%e8%86%9c%e6%80%a7%e7%b3%b8%e7%90%83%e4%bd%93%e8%85%8e%e7%82%8e%ef%bc%88membranous-nephropathy%ef%bc%89%e3%81%ae%e6%b2%bb%e7%99%82%e3%81%ab%e3%81%af%e3%80%81%e6%8d%95%e4%bd%93%e7%b5%8c%e8%b7%af\/\" class=\"home-blog-btn\">\u7d9a\u304d\u3092\u8aad\u3080<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[642],"tags":[],"class_list":["post-2595","post","type-post","status-publish","format-standard","hentry","category-nature-ja"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/2595","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/comments?post=2595"}],"version-history":[{"count":5,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/2595\/revisions"}],"predecessor-version":[{"id":5135,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/2595\/revisions\/5135"}],"wp:attachment":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/media?parent=2595"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/categories?post=2595"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/tags?post=2595"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}