{"id":2514,"date":"2021-02-20T16:10:03","date_gmt":"2021-02-20T07:10:03","guid":{"rendered":"http:\/\/www.emukk.com\/WP\/?p=2506"},"modified":"2021-02-20T16:44:58","modified_gmt":"2021-02-20T07:44:58","slug":"agalacto-i-e-glcnac-binding-lectins-bll-pvl-gsl-ii-and-bgl","status":"publish","type":"post","link":"https:\/\/www.emukk.com\/WP\/en\/agalacto-i-e-glcnac-binding-lectins-bll-pvl-gsl-ii-and-bgl\/","title":{"rendered":"Agalacto (i.e. GlcNAc) binding lectins: BLL, PVL, GSL-II, and BGL\u00a0"},"content":{"rendered":"

Agalacto type complex N-glycans without terminal Gal are often seen in autoimmune disease. Well known Lectins with glycan binding specificity to agalacto are BLL, PVL, GSL-II as shown below. BLL and PVL are mushroom derived, and GSL-II is bean derived.<\/p>\n

Boletopsis leucomelaena: BLL lectin
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Psathyrella velutina: PVL lectin
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Griffonia simplicifolia: GSL-II lectin
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A group from New England Biolabs, Inc. has identified gene sequence of Boletopsis grisea, a close North American relative of Boletopsis leucomelaena, and investigated glycan binding specificities of recombinant lectin (named rBGL) with using glycan arrays. Curiously, rBGL has bi-specific glycan binding characteristics, not only to agalacto type N-glycans but also to O-glycans with Thomsen\u2013Friedenreich antigen (TF-antigen; Gal\u03b21,3GalNAc-\u03b1-). Depending on applications, the binding specificity to O-glycan would be interesting.
\nhttps:\/\/www.nature.com\/articles\/s41598-020-80488-7<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

Agalacto type complex N-glycans without terminal Gal are often seen in autoimmune disease. Well known Lectins <\/p><\/div>\n

\u7d9a\u304d\u3092\u8aad\u3080<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[70],"tags":[],"class_list":["post-2514","post","type-post","status-publish","format-standard","hentry","category-nature-en"],"aioseo_notices":[],"aioseo_head":"\n\t\t\n\t\n\t\n\t\n\t\n\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t