{"id":2493,"date":"2021-02-20T09:16:53","date_gmt":"2021-02-20T00:16:53","guid":{"rendered":"http:\/\/www.emukk.com\/WP\/?p=2493"},"modified":"2021-07-21T23:32:28","modified_gmt":"2021-07-21T14:32:28","slug":"%e3%82%ad%e3%83%81%e3%83%8a%e3%83%bc%e3%82%bc3%e6%a7%98%e3%82%bf%e3%83%b3%e3%83%91%e3%82%af%e8%b3%aa%ef%bc%88chi3l1-ykl-40%ef%bc%89%e3%81%8c%e6%96%b0%e5%9e%8b%e3%82%b3%e3%83%ad%e3%83%8a%e3%82%a6","status":"publish","type":"post","link":"https:\/\/www.emukk.com\/WP\/%e3%82%ad%e3%83%81%e3%83%8a%e3%83%bc%e3%82%bc3%e6%a7%98%e3%82%bf%e3%83%b3%e3%83%91%e3%82%af%e8%b3%aa%ef%bc%88chi3l1-ykl-40%ef%bc%89%e3%81%8c%e6%96%b0%e5%9e%8b%e3%82%b3%e3%83%ad%e3%83%8a%e3%82%a6\/","title":{"rendered":"\u30ad\u30c1\u30ca\u30fc\u30bc3\u69d8\u30bf\u30f3\u30d1\u30af\u8cea\uff08CHI3L1\/YKL-40\uff09\u304c\u65b0\u578b\u30b3\u30ed\u30ca\u30a6\u30a4\u30eb\u30b9\uff08COVID-19\uff09\u306e\u65b0\u898f\u5275\u85ac\u30bf\u30fc\u30b2\u30c3\u30c8\u3068\u306a\u308a\u5f97\u308b"},"content":{"rendered":"<p>Brown University\u3089\u306e\u30b0\u30eb\u30fc\u30d7\u306f\u3001\u30ad\u30c1\u30ca\u30fc\u30bc3\u69d8\u30bf\u30f3\u30d1\u30af\u8cea\uff08CHI3L1\/YKL-40\uff09\u304c\u65b0\u578b\u30b3\u30ed\u30ca\u30a6\u30a4\u30eb\u30b9\uff08COVID-19\uff09\u306e\u65b0\u898f\u5275\u85ac\u30bf\u30fc\u30b2\u30c3\u30c8\u3068\u306a\u308a\u5f97\u308b\u3053\u3068\u3092\u5831\u544a\u3057\u3066\u3044\u307e\u3059\u3002<br \/>\n<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33442679\/\">https:\/\/pubmed.ncbi.nlm.nih.gov\/33442679\/<\/a><\/p>\n<p>\u65b0\u578b\u30b3\u30ed\u30ca\u30a6\u30a4\u30eb\u30b9\u306b\u611f\u67d3\u3057\u3066\u3082\u5927\u591a\u6570\u306f\u7121\u75c7\u72b6\u304b\u8efd\u75c7\u3067\u3059\u304c\u300110~20%\u306f\u5165\u9662\u3092\u4f59\u5100\u306a\u304f\u3055\u308c\u307e\u3059\u3002\u7279\u306b\u8208\u5473\u6df1\u3044\u306e\u306f\u3001COVID-19\u306e\u91cd\u75c7\u5316\u306f\u3001\u5e74\u9f62\u3084\u5408\u4f75\u75c7\u306e\u5b58\u5728\uff08\u7cd6\u5c3f\u75c5\u3001\u9ad8\u8840\u5727\u3001\u80a5\u6e80\u3001\u30e1\u30bf\u30dc\u30ea\u30c3\u30af\u30b7\u30f3\u30c9\u30ed\u30fc\u30e0\u3001\u5fc3\u8840\u7ba1\u75be\u60a3\u3001COPD\u3084\u5598\u606f\u306a\u3069\uff09\u3068\u6df1\u304f\u95a2\u4fc2\u3057\u3066\u3044\u308b\u3068\u3044\u3046\u3053\u3068\u3067\u3059\u3002CHI3L1\u306f\u3001\u708e\u75c7\u3084\u75be\u60a3\u306b\u3088\u3063\u3066\u69d8\u3005\u306a\u7d30\u80de\u304b\u3089\u5206\u6ccc\u3055\u308c\u3001\u514d\u75ab\u5fdc\u7b54\u306e\u8abf\u6574\u306b\u95a2\u4e0e\u3057\u3001\u7d30\u80de\u306e\u30a2\u30dd\u30c8\u30fc\u30b7\u30b9\u3092\u4fdd\u8b77\u3059\u308b\u3053\u3068\u3082\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u8208\u5473\u6df1\u3044\u306e\u306f\u3001CHI3L1\u306f\u3001\u5e74\u9f62\u3084COVID-19\u306e\u30ea\u30b9\u30af\u30d5\u30a1\u30af\u30bf\u30fc\u3067\u3042\u308b\u5408\u4f75\u75c7\u306e\u5b58\u5728\u3067\u5206\u6ccc\u91cf\u304c\u5897\u5927\u3059\u308b\u3068\u3044\u3046\u3053\u3068\u3067\u3059\u3002\u305d\u3053\u3067\u3001\u8457\u8005\u3089\u306f\u3001CHI3L1\u3068COVID-19\u306e\u611f\u67d3\u3067\u30ad\u30fc\u30d5\u30a1\u30af\u30bf\u30fc\u3068\u306a\u308b\u30a2\u30f3\u30b8\u30aa\u30c6\u30f3\u30b7\u30f3\u5909\u63db\u9175\u7d202\uff08ACE2\uff09\u3001\u30bf\u30f3\u30d1\u30af\u5206\u89e3\u9175\u7d20\uff08TMPRSS2\uff09\u3001\u30ea\u30bd\u30bd\u30fc\u30e0\u5185\u52a0\u6c34\u5206\u89e3\u9175\u7d20\u30ab\u30c6\u30d7\u30b7\u30f3L\uff08CTSL\uff09\u306e\u95a2\u4fc2\u6027\u306b\u7740\u76ee\u3057\u307e\u3057\u305f\u3002<\/p>\n<p>\u30de\u30a6\u30b9\u3092\u7528\u3044\u305fin vivo\u3067\u306e\u5b9f\u9a13\u3067\u306f\u3001CHI3L1\u3092\u9ad8\u767a\u73fe\u3055\u305b\u308b\u3068\u3001ACE2, TMPRSS2, CTSL\u306e\u767a\u73fe\u3082\u6709\u610f\u306b\u4e0a\u6607\u3057\u307e\u3057\u305f\u3002Calu-3\u80ba\u4e0a\u76ae\u7d30\u80de\u3092\u7528\u3044\u305fin vitro\u306e\u5b9f\u9a13\u3067\u306f\u3001CHI3L1\u306e\u30c9\u30fc\u30ba\u3068\u5171\u306bACE2, TMPRSS2, CTSL\u304c\u5358\u8abf\u306b\u5897\u52a0\u3059\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u307e\u3057\u305f\u3002\u307e\u305f\u3001CHI3L1\u306e\u30e2\u30ce\u30af\u30ed\u30ca\u30fc\u30eb\u6297\u4f53\u3067\u3042\u308bFRG\u3092\u6295\u4e0e\u3059\u308b\u3068\u3001ACE2, TMPRSS2, CTSL\u306e\u767a\u73fe\u304c\u6291\u5236\u3055\u308c\u308b\u3053\u3068\u3082\u793a\u3055\u308c\u307e\u3057\u305f\u3002COVID-19\u306e\u60a3\u8005\u306b\u304a\u3044\u3066\u3001\u305d\u306e\u91cd\u75c7\u5ea6\u3068CHI3L1\u306e\u9593\u306b\u306f\u3001\u6709\u610f\u306a\u76f8\u95a2\u95a2\u4fc2\u304c\u3042\u308b\u3053\u3068\u3082\u793a\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n<p>\u3053\u308c\u3089\u306e\u3053\u3068\u304b\u3089\u3001CHI3L1\u304cCOVID-19\u306e\u6cbb\u7642\u306b\u304a\u3044\u3066\u3001\u5275\u85ac\u30bf\u30fc\u30b2\u30c3\u30c8\u306b\u306a\u308a\u5f97\u308b\u3068\u3044\u3046\u3053\u3068\u304c\u5f37\u304f\u793a\u5506\u3055\u308c\u307e\u3059\u3002\u4eca\u5f8c\u306e\u7814\u7a76\u3092\u671f\u5f85\u3057\u307e\u3057\u3087\u3046\u3002<\/p>\n<p><a href=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/02\/CHI3LvsACE2_TMPRSS2_CTSL-1.png\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-full wp-image-2487\" src=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/02\/CHI3LvsACE2_TMPRSS2_CTSL-1.png\" alt=\"\" width=\"654\" height=\"222\" srcset=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/02\/CHI3LvsACE2_TMPRSS2_CTSL-1.png 654w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/02\/CHI3LvsACE2_TMPRSS2_CTSL-1-600x204.png 600w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/02\/CHI3LvsACE2_TMPRSS2_CTSL-1-300x102.png 300w\" sizes=\"auto, (max-width: 654px) 100vw, 654px\" \/><\/a><a href=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/02\/CHI3L1vsSeverity.png\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-full wp-image-2488\" src=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/02\/CHI3L1vsSeverity.png\" alt=\"\" width=\"261\" height=\"245\"><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Brown University\u3089\u306e\u30b0\u30eb\u30fc\u30d7\u306f\u3001\u30ad\u30c1\u30ca\u30fc\u30bc3\u69d8\u30bf\u30f3\u30d1\u30af\u8cea\uff08CHI3L1\/YKL-40\uff09\u304c\u65b0\u578b\u30b3\u30ed\u30ca\u30a6\u30a4\u30eb\u30b9\uff08COVID-19\uff09\u306e\u65b0\u898f\u5275\u85ac\u30bf\u30fc\u30b2\u30c3\u30c8\u3068\u306a\u308a\u5f97\u308b\u3053\u3068\u3092\u5831\u544a\u3057\u3066\u3044\u307e\u3059\u3002 https:\/\/pubm<\/p><\/div>\n<div class=\"blog-btn\"><a href=\"https:\/\/www.emukk.com\/WP\/%e3%82%ad%e3%83%81%e3%83%8a%e3%83%bc%e3%82%bc3%e6%a7%98%e3%82%bf%e3%83%b3%e3%83%91%e3%82%af%e8%b3%aa%ef%bc%88chi3l1-ykl-40%ef%bc%89%e3%81%8c%e6%96%b0%e5%9e%8b%e3%82%b3%e3%83%ad%e3%83%8a%e3%82%a6\/\" class=\"home-blog-btn\">\u7d9a\u304d\u3092\u8aad\u3080<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[642],"tags":[],"class_list":["post-2493","post","type-post","status-publish","format-standard","hentry","category-nature-ja"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/2493","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/comments?post=2493"}],"version-history":[{"count":3,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/2493\/revisions"}],"predecessor-version":[{"id":5139,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/2493\/revisions\/5139"}],"wp:attachment":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/media?parent=2493"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/categories?post=2493"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/tags?post=2493"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}