{"id":2393,"date":"2021-02-17T13:43:26","date_gmt":"2021-02-17T04:43:26","guid":{"rendered":"http:\/\/www.emukk.com\/WP\/?p=2393"},"modified":"2021-02-17T15:10:55","modified_gmt":"2021-02-17T06:10:55","slug":"%e4%b9%b3%e7%99%8c%e3%82%84%e5%8d%b5%e5%b7%a3%e7%99%8c%e3%81%ab%e5%af%be%e3%81%99%e3%82%8bgalectin-3%e3%82%92%e6%a8%99%e7%9a%84%e3%81%a8%e3%81%99%e3%82%8b%e6%b2%bb%e7%99%82%e8%96%ac%e3%81%ae%e6%9c%89","status":"publish","type":"post","link":"https:\/\/www.emukk.com\/WP\/%e4%b9%b3%e7%99%8c%e3%82%84%e5%8d%b5%e5%b7%a3%e7%99%8c%e3%81%ab%e5%af%be%e3%81%99%e3%82%8bgalectin-3%e3%82%92%e6%a8%99%e7%9a%84%e3%81%a8%e3%81%99%e3%82%8b%e6%b2%bb%e7%99%82%e8%96%ac%e3%81%ae%e6%9c%89\/","title":{"rendered":"\u4e73\u764c\u3084\u5375\u5de3\u764c\u306b\u5bfe\u3059\u308bGalectin-3\u3092\u6a19\u7684\u3068\u3059\u308b\u6cbb\u7642\u85ac\u306e\u6709\u52b9\u6027"},"content":{"rendered":"

Memorial Sloan Kettering Cancer Center, New York\u3089\u306e\u30b0\u30eb\u30fc\u30d7\u306f\u3001\u4e73\u764c\u3084\u5375\u5de3\u764c\u306b\u5bfe\u3059\u308bGalectin-3\u3092\u6a19\u7684\u3068\u3059\u308b\u6cbb\u7642\u85ac\u306e\u958b\u767a\u306b\u3064\u3044\u3066\u5831\u544a\u3057\u3066\u3044\u307e\u3059\u3002
\nhttps:\/\/www.nature.com\/articles\/s41598-021-82686-3<\/a><\/p>\n

\u5375\u5de3\u304c\u3093\u3084\u4e73\u764c\u306a\u3069\u3067\u306f\u3001CA125\u30a8\u30d4\u30c8\u30fc\u30d7\u3092\u6301\u3064MUC16\u3068\u540d\u4ed8\u3051\u3089\u308c\u305f\u30e0\u30c1\u30f3\u304c\u9ad8\u767a\u73fe\u3057\u3066\u3044\u307e\u3059\u3002\u30e0\u30c1\u30f3\u306fO\u578b\u7cd6\u9396\u306e\u4fee\u98fe\u3092\u5f37\u304f\u53d7\u3051\u3066\u304a\u308a\u3001\u672b\u7aef\u90e8\u306b\u306fpoly LacNAc\u69cb\u9020\u304c\u4ed8\u52a0\u3057\u3066\u7cd6\u9396\u304c\u4f38\u9577\u3057\u3066\u3044\u308b\u5834\u5408\u3082\u3042\u308a\u307e\u3059\u3002Galectin-3\uff08Gal-3\uff09\u306f\u3001poly LacNAc\u306b\u30a2\u30d5\u30a3\u30cb\u30c6\u30a3\u30fc\u3092\u6301\u3061\u3001\u305d\u308c\u6545\u3001Gal-3\u306fMUC16\u306b\u7cd6\u9396\u3092\u4ecb\u3057\u3066\u7d50\u5408\u3057\u307e\u3059\u3002Galectin family\u306f\u591a\u69d8\u306a\u6a5f\u80fd\u3092\u6301\u3061\u307e\u3059\u304c\u3001MUC16\u306f\u764c\u7d30\u80de\u3068\u306e\u95a2\u4fc2\u304c\u6df1\u304f\u3001\u764c\u306e\u5897\u6b96\u3084\u6d78\u6f64\u306b\u95a2\u4fc2\u3057\u3066\u3044\u308b\u3068\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n

\u8457\u8005\u3089\u306f\u3001Gal-3\u306b\u5bfe\u3059\u308b\u30e2\u30ce\u30af\u30ed\u30ca\u30fc\u30eb\u6297\u4f53\uff0814D11\uff09\u3092\u7528\u3044\u3066\u3001\u5375\u5de3\u304c\u3093\u3084\u4e73\u764c\u306b\u5bfe\u3059\u308bGal-3\u306e\u963b\u5bb3\u52b9\u679c\u3092in vitro\u304a\u3088\u3073in vivo\u3067\u8a55\u4fa1\u3057\u307e\u3057\u305f\u3002Gal-3\u3068LacNAc\u306eKd\u5024\u306f\uff5e0.2mM\u3067\u3042\u308a\u3001Gal-3\u306814D11\u306eKd\u5024\u306f\uff5e14.6nM\u3067\u3057\u305f\u3002\u5f93\u3063\u3066\u300114D11\u306e\u65b9\u304c13,000\u500d\u7a0b\u5f37\u3044\u30a2\u30d5\u30a3\u30cb\u30c6\u30a3\u30fc\u3092\u6301\u3064\u3053\u3068\u306b\u306a\u308a\u307e\u3059\u3002<\/p>\n

MUC16\u3092\u9ad8\u767a\u73fe\u3059\u308b\u3075\u305f\u3064\u306e\u5375\u5de3\u304c\u3093\u682a\uff08A2780, SKOV3\uff09\u3092\u30de\u30a6\u30b9\u306b\u79fb\u690d\u3057\u300114D11\u6295\u4e0e\u306e\u52b9\u679c\u3092\u751f\u5b58\u7387\u3067\u6bd4\u8f03\u3057\u305f\u3082\u306e\u304c\u4e0b\u8a18\u3067\u3059\u3002<\/p>\n

\"\"<\/a><\/p>\n

\u307e\u305f\u3001\u4e73\u817a\u764c\u7d30\u80de\uff08MDA-MB-231)\u3092\u30de\u30a6\u30b9\u306b\u79fb\u690d\u3057\u300114D11\u6295\u4e0e\u306e\u52b9\u679c\u3092\u6bd4\u8f03\u3057\u305f\u3082\u306e\u304c\u4e0b\u8a18\u3067\u3059\u3002\u3053\u308c\u3089\u306e\u5b9f\u9a13\u7d50\u679c\u306f\u3001Gal-3\u306e\u963b\u5bb3\u306b\u3088\u3063\u3066\u764c\u306e\u5897\u6b96\u3092\u6291\u3048\u308b\u3053\u3068\u304c\u3067\u304d\u308b\u3053\u3068\u3092\u5982\u5b9f\u306b\u793a\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n

\"\"<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

Memorial Sloan Kettering Cancer Center, New York\u3089\u306e\u30b0\u30eb\u30fc\u30d7\u306f\u3001\u4e73\u764c\u3084\u5375\u5de3\u764c\u306b\u5bfe\u3059\u308bGalectin-3\u3092\u6a19\u7684\u3068\u3059\u308b\u6cbb\u7642\u85ac\u306e\u958b\u767a\u306b\u3064\u3044\u3066\u5831\u544a\u3057\u3066\u3044\u307e\u3059\u3002 https:\/\/w<\/p><\/div>\n

\u7d9a\u304d\u3092\u8aad\u3080<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[42],"tags":[],"class_list":["post-2393","post","type-post","status-publish","format-standard","hentry","category-technology-ja"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/2393","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/comments?post=2393"}],"version-history":[{"count":8,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/2393\/revisions"}],"predecessor-version":[{"id":2410,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/2393\/revisions\/2410"}],"wp:attachment":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/media?parent=2393"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/categories?post=2393"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/tags?post=2393"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}