{"id":2367,"date":"2021-02-16T13:46:59","date_gmt":"2021-02-16T04:46:59","guid":{"rendered":"http:\/\/www.emukk.com\/WP\/?p=2363"},"modified":"2021-02-16T14:25:46","modified_gmt":"2021-02-16T05:25:46","slug":"strain-determination-of-influenza-virus-using-glycan-array-formed-on-an-arrayed-imaging-reflectometry-air-platform","status":"publish","type":"post","link":"https:\/\/www.emukk.com\/WP\/en\/strain-determination-of-influenza-virus-using-glycan-array-formed-on-an-arrayed-imaging-reflectometry-air-platform\/","title":{"rendered":"Strain determination of influenza virus using glycan array formed on an Arrayed Imaging Reflectometry (AIR) platform"},"content":{"rendered":"

A group from Univ. of Rochester’s group has developed and used sensor chips with various glycans immobilized on the Arrayed Imaging Reflectometry (AIR) platform as a simple way to detect the hemagglutinin subtypes of influenza viruses and the subtypes of neuraminidase.
\nhttps:\/\/pubs.acs.org\/doi\/10.1021\/acs.bioconjchem.0c00718<\/a><\/p>\n

What is more curious is what is the Arrayed Imaging Reflectometry (AIR) platform rather than the application example itself. This platform seemed to be developed in Benjamin Miller Lab., Univ. of Rochester. The principle is physically very simple, growing a thin oxide on a Si substrate with the mirror surface, and using the interference effect of light reflected on the upper and lower surfaces of SiO2 (i.e., at the SiO2\/Si interface). There could be a reflection condition that the surface becomes non-reflective as a result of the interference of the diagonally incident light onto the substrate, and molecular interaction between probes pre-fixed on the substrate and applied ligands happens, reflected light appears depending on degree of disruption of the light interference. Therefore, like SPR, AIR does not need fluorescence labeling to the sample (i.e., label-free). The question about this technology would be the sensitivity. However, the above example explained that it provides comparable or better sensitivity than SPR.
\nhttps:\/\/www.urmc.rochester.edu\/labs\/benjamin-miller\/projects\/arrayed-imaging-reflectometry.aspx<\/a><\/p>\n

\"\"<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

A group from Univ. of Rochester’s group has developed and used sensor chips with various glycans immobil<\/p><\/div>\n

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