{"id":2350,"date":"2021-02-16T11:04:35","date_gmt":"2021-02-16T02:04:35","guid":{"rendered":"http:\/\/www.emukk.com\/WP\/?p=2344"},"modified":"2021-02-16T15:52:26","modified_gmt":"2021-02-16T06:52:26","slug":"prognostic-markers-for-iga-nephropathy-lectins-detect-changes-in-glycan-modification","status":"publish","type":"post","link":"https:\/\/www.emukk.com\/WP\/en\/prognostic-markers-for-iga-nephropathy-lectins-detect-changes-in-glycan-modification\/","title":{"rendered":"Prognostic markers for IgA nephropathy: Lectins detect changes in glycan modification"},"content":{"rendered":"<p>A group from Okayama University School of Medicine has reported on a study focusing on glycans and lectins as prognosis markers for IgA nephropathy.<br \/>\n<a href=\"https:\/\/www.nature.com\/articles\/s41598-020-77736-1\">https:\/\/www.nature.com\/articles\/s41598-020-77736-1<\/a><\/p>\n<p>They have found excellent prognostic markers from urine as a diagnostic sample with using lectin microarrays for 157 IgA nephropathy patients who received a renal biopsy from 2010 to 2017 at Okayama University Hospital.<br \/>\nThe prognosis outcome were based on a decrease in glomerular filter rate (eGFR) (&gt; 4 mL\/min\/1.73 m2\/year), or eGFR \u2265 30% decline from baseline. T Score was used for the statistical evaluation, and\u00a0 it was found that ECA lectins (with glycan binding specificity to Gal\u03b21-4GlcNAc) and NPA lectins (with glycan binding specificity to High Mannose) could be good prognostic markers.<br \/>\nECA:(odds ratio[OR] 2.84, 95% confidence interval[CI] 1.11\u20137.28)<br \/>\nNPA:(OR 2.32, 95% CI 1.11\u20134.85)<br \/>\nT Score is calculated by multiplying the standardized percentile rank by 10 and adding 50. T0, T1, T2 indicate Oxford classification about tubular atrophy and interstitial fibrosis.<\/p>\n<p><a href=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/02\/IgA-nephropathy.png\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-medium wp-image-2345\" src=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/02\/IgA-nephropathy-300x130.png\" alt=\"\" width=\"300\" height=\"130\" srcset=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/02\/IgA-nephropathy-300x130.png 300w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/02\/IgA-nephropathy-600x260.png 600w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/02\/IgA-nephropathy-768x333.png 768w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/02\/IgA-nephropathy.png 820w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>A group from Okayama University School of Medicine has reported on a study focusing on glycans and lectins as <\/p><\/div>\n<div class=\"blog-btn\"><a href=\"https:\/\/www.emukk.com\/WP\/en\/prognostic-markers-for-iga-nephropathy-lectins-detect-changes-in-glycan-modification\/\" class=\"home-blog-btn\">\u7d9a\u304d\u3092\u8aad\u3080<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[7],"tags":[],"class_list":["post-2350","post","type-post","status-publish","format-standard","hentry","category-technology-en"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/2350","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/comments?post=2350"}],"version-history":[{"count":10,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/2350\/revisions"}],"predecessor-version":[{"id":2378,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/2350\/revisions\/2378"}],"wp:attachment":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/media?parent=2350"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/categories?post=2350"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/tags?post=2350"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}