{"id":2276,"date":"2021-02-12T08:38:04","date_gmt":"2021-02-11T23:38:04","guid":{"rendered":"http:\/\/www.emukk.com\/WP\/?p=2272"},"modified":"2021-02-12T08:49:49","modified_gmt":"2021-02-11T23:49:49","slug":"%e4%bd%95%e6%95%85%e3%80%81sars-cov-2-20i-501y-v1%e8%8b%b1%e5%9b%bd%e5%a4%89%e7%95%b0%e6%a0%aa%e3%81%a7%e3%81%af%e3%80%81%e6%84%9f%e6%9f%93%e5%8a%9b%e3%81%8c%e3%82%a2-%e3%83%83%e3%83%97%e3%81%99","status":"publish","type":"post","link":"https:\/\/www.emukk.com\/WP\/en\/%e4%bd%95%e6%95%85%e3%80%81sars-cov-2-20i-501y-v1%e8%8b%b1%e5%9b%bd%e5%a4%89%e7%95%b0%e6%a0%aa%e3%81%a7%e3%81%af%e3%80%81%e6%84%9f%e6%9f%93%e5%8a%9b%e3%81%8c%e3%82%a2-%e3%83%83%e3%83%97%e3%81%99\/","title":{"rendered":"Why SARS-CoV-2 (20I\/501Y. V1) UK Variant does increase its infectability?"},"content":{"rendered":"<p>A group from Anschutz Medical Center, University of Colorado etc. has analyzed why does the SARS-CoV-2 (20I\/501Y. V1) UK variant increase its infectability? using a molecular docking method.<br \/>\n<a href=\"https:\/\/www.biorxiv.org\/content\/10.1101\/2021.02.02.428884v1.full\">https:\/\/www.biorxiv.org\/content\/10.1101\/2021.02.02.428884v1.full<\/a><\/p>\n<p>Comparing with the wild type N501, RBD of the mutant Y501 binds to ACE2 about 10 times more tightly, because a new hydrogen bond is formed between RBD and ACE2 (bold dashed line in the figure below), and there is a ring-ring interaction (light dashed line in the figure below).<\/p>\n<p><a href=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/02\/Y501-variant.png\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-medium wp-image-2273\" src=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/02\/Y501-variant-300x254.png\" alt=\"\" width=\"300\" height=\"254\" srcset=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/02\/Y501-variant-300x254.png 300w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/02\/Y501-variant-600x509.png 600w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/02\/Y501-variant.png 651w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>A group from Anschutz Medical Center, University of Colorado etc. has analyzed why does the SARS-CoV-2 (20I\/50<\/p><\/div>\n<div class=\"blog-btn\"><a href=\"https:\/\/www.emukk.com\/WP\/en\/%e4%bd%95%e6%95%85%e3%80%81sars-cov-2-20i-501y-v1%e8%8b%b1%e5%9b%bd%e5%a4%89%e7%95%b0%e6%a0%aa%e3%81%a7%e3%81%af%e3%80%81%e6%84%9f%e6%9f%93%e5%8a%9b%e3%81%8c%e3%82%a2-%e3%83%83%e3%83%97%e3%81%99\/\" class=\"home-blog-btn\">\u7d9a\u304d\u3092\u8aad\u3080<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[70],"tags":[],"class_list":["post-2276","post","type-post","status-publish","format-standard","hentry","category-nature-en"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/2276","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/comments?post=2276"}],"version-history":[{"count":3,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/2276\/revisions"}],"predecessor-version":[{"id":2279,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/2276\/revisions\/2279"}],"wp:attachment":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/media?parent=2276"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/categories?post=2276"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/tags?post=2276"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}