{"id":2086,"date":"2021-02-03T10:44:01","date_gmt":"2021-02-03T01:44:01","guid":{"rendered":"http:\/\/www.emukk.com\/WP\/?p=2079"},"modified":"2021-02-03T10:56:44","modified_gmt":"2021-02-03T01:56:44","slug":"genetic-variants-in-mannose-binding-lectin-mbl-appears-to-be-significantly-related-to-the-severity-of-the-new-coronavirus-covid-19","status":"publish","type":"post","link":"https:\/\/www.emukk.com\/WP\/en\/genetic-variants-in-mannose-binding-lectin-mbl-appears-to-be-significantly-related-to-the-severity-of-the-new-coronavirus-covid-19\/","title":{"rendered":"Genetic variants in Mannose Binding Lectin (MBL) appears to be significantly related to the severity of the new coronavirus (COVID-19)"},"content":{"rendered":"<p>It is known that there are three type of innate immunity, (1)phagocytosis with phagocytic cells such as macrophages and NK cells, (2)complement lectin pathways, and (3)extra-spherical traps . In the complement lectin pathway, Mannose Binding Lectin (MBL) plays a central role, and when MBL binds to the mannose on the pathogen&#8217;s cell membrane, an enzyme called MBL-binding serine protease (MASP) bound to MBL is activated, and MASP activates the complement Factor 4 (C4), which sequentially activates the complements and ultimately kills it by drilling a hole in the pathogen&#8217;s cell membrane.<\/p>\n<p>A group of Istanbul Faculty of Medicine, Istanbul Univ. has reported that the genetic variants in MBL are largely related to the severity of covid-19.<br \/>\n<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7838598\/\">https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7838598\/<\/a><\/p>\n<p>For the mutation of codon52 of the MBL2 gene,<br \/>\nReferring to AA genotype,<br \/>\nBB genotype: odds ratio (OR)\u202f=\u202f5.3, p&lt;\u202f0.001;<br \/>\nAB genotype: OR\u202f=\u202f2.9, p\u202f=\u202f0.001<\/p>\n<p>For the ICU need, the odds ratios get higher as follows,<br \/>\nBB genotype: OR\u202f=\u202f19.6, p\u202f&lt;\u202f0.001<br \/>\nAB genotype: OR\u202f=\u202f6.9, p\u202f=\u202f0.001<\/p>\n<p>This could be a good reference in using MBL as a therapeutic protein.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>It is known that there are three type of innate immunity, (1)phagocytosis with phagocytic cells such as macrop<\/p><\/div>\n<div class=\"blog-btn\"><a href=\"https:\/\/www.emukk.com\/WP\/en\/genetic-variants-in-mannose-binding-lectin-mbl-appears-to-be-significantly-related-to-the-severity-of-the-new-coronavirus-covid-19\/\" class=\"home-blog-btn\">\u7d9a\u304d\u3092\u8aad\u3080<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[70],"tags":[],"class_list":["post-2086","post","type-post","status-publish","format-standard","hentry","category-nature-en"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/2086","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/comments?post=2086"}],"version-history":[{"count":2,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/2086\/revisions"}],"predecessor-version":[{"id":2088,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/2086\/revisions\/2088"}],"wp:attachment":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/media?parent=2086"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/categories?post=2086"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/tags?post=2086"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}