{"id":2046,"date":"2021-01-26T14:00:09","date_gmt":"2021-01-26T05:00:09","guid":{"rendered":"http:\/\/www.emukk.com\/WP\/?p=2042"},"modified":"2021-01-26T17:02:47","modified_gmt":"2021-01-26T08:02:47","slug":"are-glycans-related-to-adeno-associated-virus-aav-targeting-performance","status":"publish","type":"post","link":"https:\/\/www.emukk.com\/WP\/en\/are-glycans-related-to-adeno-associated-virus-aav-targeting-performance\/","title":{"rendered":"Are glycans related to the tissue targeting performance of Adeno-associated virus (AAV)?"},"content":{"rendered":"<p>In gene therapy using Adeno-associated virus (AAV), it has been suggested that there are some differences in AAV capsids in terms of tissue targeting ability, and it has been told that glycans may be involved in he AAV&#8217;s tissue targeting ability. Such arguments have been around for quite some time.<br \/>\nFor example, the following papers are references.<br \/>\n<a href=\"https:\/\/www.nature.com\/articles\/gt201316\">https:\/\/www.nature.com\/articles\/gt201316<\/a><br \/>\n<a href=\"https:\/\/www.jbc.org\/article\/S0021-9258(20)51734-1\/fulltext\">https:\/\/www.jbc.org\/article\/S0021-9258(20)51734-1\/fulltext<\/a><br \/>\n<a href=\"https:\/\/www.jbc.org\/article\/S0021-9258(20)48853-2\/fulltext\">https:\/\/www.jbc.org\/article\/S0021-9258(20)48853-2\/fulltext<\/a><br \/>\n<a href=\"https:\/\/jvi.asm.org\/content\/80\/18\/9093\">https:\/\/jvi.asm.org\/content\/80\/18\/9093<\/a><\/p>\n<p>Specifically, it has been reported that AAV-1 and AAV-6 bind to Sialic acid, AAV-2 binds to Heparan sulfate, and AAV-9 binds to Galatose.<br \/>\nBut, is it true?<br \/>\nTo this blog admin., it is a kind of unbelievable thing that capsid proteins have lectin-like functions?<\/p>\n","protected":false},"excerpt":{"rendered":"<p>In gene therapy using Adeno-associated virus (AAV), it has been suggested that there are some differences in A<\/p><\/div>\n<div class=\"blog-btn\"><a href=\"https:\/\/www.emukk.com\/WP\/en\/are-glycans-related-to-adeno-associated-virus-aav-targeting-performance\/\" class=\"home-blog-btn\">\u7d9a\u304d\u3092\u8aad\u3080<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[7],"tags":[],"class_list":["post-2046","post","type-post","status-publish","format-standard","hentry","category-technology-en"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/2046","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/comments?post=2046"}],"version-history":[{"count":4,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/2046\/revisions"}],"predecessor-version":[{"id":2052,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/2046\/revisions\/2052"}],"wp:attachment":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/media?parent=2046"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/categories?post=2046"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/tags?post=2046"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}