{"id":2023,"date":"2021-01-25T16:10:53","date_gmt":"2021-01-25T07:10:53","guid":{"rendered":"http:\/\/www.emukk.com\/WP\/?p=2018"},"modified":"2021-01-25T16:40:33","modified_gmt":"2021-01-25T07:40:33","slug":"microrna-mir-630-derived-from-tonsils-may-be-deeply-involved-in-iga-nephropathy","status":"publish","type":"post","link":"https:\/\/www.emukk.com\/WP\/en\/microrna-mir-630-derived-from-tonsils-may-be-deeply-involved-in-iga-nephropathy\/","title":{"rendered":"MicroRNA (miR-630) derived from tonsils may be deeply involved in IgA nephropathy"},"content":{"rendered":"<p>IgA nephropathy is a typical intractable disease of chronic kidney disease in which IgA (one of the immunoglobulins) is deposited in the glomerulus (a urine filtration device) with aberrant glycan modification. It is also well known that abnormalities occur in the O-glycan modification in the IgA hinge region.<br \/>\nA group from Central South University, Changsha, China etc. has indicated that IgA, the glycan abnormality found in IgA nephropathy, might be controlled by microRNA (miR-630) derived from tonsil mononucleated cells.<br \/>\n<a href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2020.563699\/full\">https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2020.563699\/full<\/a><\/p>\n<p>As for the mechanism of the onset of IgA nephropathy, it was suggested that miR-630 derived from the tonsils is produced excessively,\u00a0 and targets Toll-like receptor 4 (TLR4)\u00a0 as the target gene, and finally modulates the concentration of IgA and its glycosylation level through the NF-kB signaling pathway.<\/p>\n<p><a href=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/01\/IgA_miR-630.png\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-medium wp-image-2020\" src=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/01\/IgA_miR-630-300x155.png\" alt=\"\" width=\"300\" height=\"155\" srcset=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/01\/IgA_miR-630-300x155.png 300w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/01\/IgA_miR-630-600x310.png 600w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/01\/IgA_miR-630.png 765w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>IgA nephropathy is a typical intractable disease of chronic kidney disease in which IgA (one of the immunoglob<\/p><\/div>\n<div class=\"blog-btn\"><a href=\"https:\/\/www.emukk.com\/WP\/en\/microrna-mir-630-derived-from-tonsils-may-be-deeply-involved-in-iga-nephropathy\/\" class=\"home-blog-btn\">\u7d9a\u304d\u3092\u8aad\u3080<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[70],"tags":[],"class_list":["post-2023","post","type-post","status-publish","format-standard","hentry","category-nature-en"],"aioseo_notices":[],"aioseo_head":"\n\t\t<!-- All in One SEO 4.9.8 - aioseo.com -->\n\t<meta name=\"description\" content=\"IgA nephropathy is a typical intractable disease of chr\" \/>\n\t<meta name=\"robots\" content=\"max-image-preview:large\" \/>\n\t<meta name=\"author\" content=\"Mx\"\/>\n\t<link rel=\"canonical\" href=\"https:\/\/www.emukk.com\/WP\/en\/microrna-mir-630-derived-from-tonsils-may-be-deeply-involved-in-iga-nephropathy\/\" \/>\n\t<meta name=\"generator\" content=\"All in One SEO (AIOSEO) 4.9.8\" \/>\n\t\t<meta property=\"og:locale\" content=\"ja_JP\" \/>\n\t\t<meta property=\"og:site_name\" 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