{"id":2009,"date":"2021-01-24T15:10:52","date_gmt":"2021-01-24T06:10:52","guid":{"rendered":"http:\/\/www.emukk.com\/WP\/?p=2006"},"modified":"2021-01-24T15:33:19","modified_gmt":"2021-01-24T06:33:19","slug":"changes-in-glycan-modification-accompanied-by-change-from-esc-to-epiblast-like-cells-epilcs-and-its-control-factor-behind-them","status":"publish","type":"post","link":"https:\/\/www.emukk.com\/WP\/en\/changes-in-glycan-modification-accompanied-by-change-from-esc-to-epiblast-like-cells-epilcs-and-its-control-factor-behind-them\/","title":{"rendered":"Changes in glycan modification accompanied by change from ESC to epiblast-like cells (EpiLCs) and its control factor behind them"},"content":{"rendered":"

A group from Soka University etc. has reported on changes in glycan modification accompanied by change from ESC to epiblast-like cells (EpiLCs) and a control factor behind them.
\nhttps:\/\/www.nature.com\/articles\/s41598-020-79666-4<\/a><\/p>\n

With the change from ESC to EpiLCs, the following changes in glycan modification occur:<\/p>\n

    \n
  1. For N-type glycans, the high mannose structure is the main structure in common, but in EpiLCs, fucose modification, bisecting, and Sia modification are increased, for Sia, \u03b12-6 is the main linkage, and typeI LacNAc (Gal\u03b21-3GlcNAc) is highly expressed with \u03b11-2Fuc modified.<\/li>\n
  2. For O-type sugar chains, Tn antigen and O-GlcNAc are the main in common, but in EpiLCs, the expression of O-glycan is generally increasing, and elongated mucin type O-glycans also increase.<\/li>\n
  3. For Glycosaminoglycans (GAG), EpiLCs generally increase GAG expression, especially Heparan sulfate (HS), chondroitin sulfate (CS) and dermatan sulfate (DS).<\/li>\n
  4. For glycolipids, EpiLCs cause structural changes from globo (Gb) to ganglio (Gg).<\/li>\n<\/ol>\n

    Behind these glycan modification, polycomb repressive complex 2 (PRC2), a chromatin protein, was shown to be involved as a regulator. A number of glycosyltransferase genes involved in glycan modification of ESC is under the control of PRC2.<\/p>\n","protected":false},"excerpt":{"rendered":"

    A group from Soka University etc. has reported on changes in glycan modification accompanied by change from ES<\/p><\/div>\n

    \u7d9a\u304d\u3092\u8aad\u3080<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[70],"tags":[],"class_list":["post-2009","post","type-post","status-publish","format-standard","hentry","category-nature-en"],"aioseo_notices":[],"aioseo_head":"\n\t\t\n\t\n\t\n\t\n\t\n\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t