{"id":1999,"date":"2021-01-24T11:55:09","date_gmt":"2021-01-24T02:55:09","guid":{"rendered":"http:\/\/www.emukk.com\/WP\/?p=1994"},"modified":"2021-01-24T17:12:32","modified_gmt":"2021-01-24T08:12:32","slug":"characteristic-changes-in-glycan-modification-in-high-grade-gliomas","status":"publish","type":"post","link":"https:\/\/www.emukk.com\/WP\/en\/characteristic-changes-in-glycan-modification-in-high-grade-gliomas\/","title":{"rendered":"Characteristic changes in glycan modification in high-grade gliomas"},"content":{"rendered":"

A group of Quilmes National University, Bernal, Buenos Aires Province, Argentina has reported characteristic glycan modification in gliomas.
\nhttps:\/\/www.oncotarget.com\/article\/27850\/text\/<\/a><\/p>\n

In high-grade gliomas, its glycan modification is characterized by the progression of terminal sialic acid of N-glycans and multi-antennary N-glycans. The sialic acid modification is mainly \u03b12-3 linkage along with the terminal fucosylation, suggesting that the terminal modification structure of N-glycans is SLex. To support this, glycosyltransferases (\u03b11,3-fucosyltransperases (FuT3-7 and 9-11) and \u03b12,3-sialyltransferases (ST3Gal3\/4\/6) ) are also highly expressed.<\/p>\n

They concluded that changes in the glycan profile of tumor cell surfaces are the basis for the development of therapeutic drugs targeting such aberrant glycans and novel glycan markers.<\/p>\n

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A group of Quilmes National University, Bernal, Buenos Aires Province, Argentina has reported characteristic g<\/p><\/div>\n

\u7d9a\u304d\u3092\u8aad\u3080<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[70],"tags":[],"class_list":["post-1999","post","type-post","status-publish","format-standard","hentry","category-nature-en"],"aioseo_notices":[],"aioseo_head":"\n\t\t\n\t\n\t\n\t\n\t\n\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t