{"id":1961,"date":"2021-01-23T14:03:03","date_gmt":"2021-01-23T05:03:03","guid":{"rendered":"http:\/\/www.emukk.com\/WP\/?p=1961"},"modified":"2021-12-07T15:22:35","modified_gmt":"2021-12-07T06:22:35","slug":"%e6%96%b0%e3%81%97%e3%81%84%e4%b8%8d%e6%ad%bb%e5%8c%96%e8%82%9d%e7%b4%b0%e8%83%9e%e6%a0%aa%e3%80%81hepamn%e3%80%81%e3%81%ae%e6%a8%b9%e7%ab%8b%e3%81%a8%e3%81%9d%e3%81%ae%e7%89%b9%e6%80%a7","status":"publish","type":"post","link":"https:\/\/www.emukk.com\/WP\/%e6%96%b0%e3%81%97%e3%81%84%e4%b8%8d%e6%ad%bb%e5%8c%96%e8%82%9d%e7%b4%b0%e8%83%9e%e6%a0%aa%e3%80%81hepamn%e3%80%81%e3%81%ae%e6%a8%b9%e7%ab%8b%e3%81%a8%e3%81%9d%e3%81%ae%e7%89%b9%e6%80%a7\/","title":{"rendered":"\u65b0\u3057\u3044\u4e0d\u6b7b\u5316\u809d\u7d30\u80de\u682a\u3001HepaMN\u3001\u306e\u6a39\u7acb\u3068\u305d\u306e\u7279\u6027"},"content":{"rendered":"<p>\u809d\u7d30\u80de\u306f\u3001in vitro\u3067\u306e\u533b\u85ac\u54c1\u306e\u6bd2\u6027\u691c\u67fb\u3067\u6b20\u304b\u305b\u306a\u3044\u7d30\u80de\u3067\u3059\u3002HepG2, Huh7, THLE-2, PLC-PRF-5, and AML-12\u3068\u3044\u3063\u305f\u809d\u7d30\u80de\u682a\u304c\u5229\u7528\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u56fd\u7acb\u6210\u80b2\u533b\u7642\u7814\u7a76\u30bb\u30f3\u30bf\u30fc\u3089\u306e\u30b0\u30eb\u30fc\u30d7\u306f\u3001\u80c6\u9053\u9589\u9396\u75c7\u3092\u767a\u75c7\u3057\u305f\u809d\u7d30\u80de\u304b\u3089HepaMN\u3068\u547d\u540d\u3055\u308c\u305f\u65b0\u3057\u3044\u4e0d\u6b7b\u5316\u809d\u7d30\u80de\u682a\u3092\u6a39\u7acb\u3057\u307e\u3057\u305f\u3002\u4e0d\u6b7b\u5316\u306f\u3001CDK4, cyclin D1, and TERT\u306e\u907a\u4f1d\u5b50\u5c0e\u5165\u306b\u3088\u308a\u884c\u308f\u308c\u307e\u3057\u305f\u3002<br \/>\n<a href=\"https:\/\/www.nature.com\/articles\/s41598-020-73992-3\">https:\/\/www.nature.com\/articles\/s41598-020-73992-3<\/a><\/p>\n<p>HepaMN\u682a\u306e\u7279\u5fb4\u306b\u3064\u3044\u3066\uff1a<br \/>\n\u975e\u5f62\u8cea\u8ee2\u63db\u809d\u7d30\u80de\u304b\u3089\u6a39\u7acb\u3055\u308c\u3066\u304a\u308a\u6b63\u5e38\u306a\u809d\u6a5f\u80fd\u3068\u4e8c\u500d\u4f53\u3092\u6301\u3064<br \/>\nHepaRG\u3068\u540c\u30ec\u30d9\u30eb\u306e\u30a2\u30eb\u30d6\u30df\u30f3\u907a\u4f1d\u5b50\u306e\u767a\u73fe\u3092\u793a\u3059<br \/>\n\u809d\u7d30\u80de\u306e\u7d30\u80de\u5f62\u614b\u3092\u793a\u3059<br \/>\n\u5b89\u5b9a\u3057\u305f\u30b7\u30c8\u30af\u30ed\u30e0P450 3A4 (CYP3A4) \u3092\u8a98\u5c0e\u3057\u3001\u6b63\u5e38\u306a\u4ee3\u8b1d\u4f5c\u7528\u3092\u793a\u3059<br \/>\n\u52b9\u7387\u3088\u304f\u5897\u6b96\u3057\u3001\u975e\u5e38\u306b\u9577\u3044\u30d1\u30c3\u30bb\u30fc\u30b8\u3067\u3082\u5b89\u5b9a\u3067\u3042\u308b<br \/>\n\u7d50\u679c\u3068\u3057\u3066\u3001\u6bd2\u6027\u691c\u67fb\u306b\u65b0\u3057\u3044\u6709\u7528\u306a\u809d\u7d30\u80de\u682a\u3092\u63d0\u4f9b\u3067\u304d\u305f\u3068\u3057\u3066\u3044\u307e\u3059\u3002<br \/>\n<a href=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/01\/HepaMN.png\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-medium wp-image-1963\" src=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/01\/HepaMN-211x300.png\" alt=\"\" width=\"211\" height=\"300\" srcset=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/01\/HepaMN-211x300.png 211w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2021\/01\/HepaMN.png 460w\" sizes=\"auto, (max-width: 211px) 100vw, 211px\" \/><\/a><\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>HepaMN\u7d30\u80de\u306e\u57f9\u990a\u306b\u306f\u3001EMUKK-15\u304c\u63a8\u5968\u3055\u308c\u307e\u3059\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u809d\u7d30\u80de\u306f\u3001in vitro\u3067\u306e\u533b\u85ac\u54c1\u306e\u6bd2\u6027\u691c\u67fb\u3067\u6b20\u304b\u305b\u306a\u3044\u7d30\u80de\u3067\u3059\u3002HepG2, Huh7, THLE-2, PLC-PRF-5, and AML-12\u3068\u3044\u3063\u305f\u809d\u7d30\u80de\u682a\u304c\u5229\u7528\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u56fd\u7acb\u6210\u80b2\u533b\u7642\u7814\u7a76\u30bb\u30f3\u30bf\u30fc\u3089\u306e\u30b0\u30eb<\/p><\/div>\n<div class=\"blog-btn\"><a href=\"https:\/\/www.emukk.com\/WP\/%e6%96%b0%e3%81%97%e3%81%84%e4%b8%8d%e6%ad%bb%e5%8c%96%e8%82%9d%e7%b4%b0%e8%83%9e%e6%a0%aa%e3%80%81hepamn%e3%80%81%e3%81%ae%e6%a8%b9%e7%ab%8b%e3%81%a8%e3%81%9d%e3%81%ae%e7%89%b9%e6%80%a7\/\" class=\"home-blog-btn\">\u7d9a\u304d\u3092\u8aad\u3080<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[42],"tags":[],"class_list":["post-1961","post","type-post","status-publish","format-standard","hentry","category-technology-ja"],"aioseo_notices":[],"aioseo_head":"\n\t\t<!-- All in One SEO 4.9.8 - aioseo.com -->\n\t<meta name=\"description\" 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