{"id":1796,"date":"2021-01-16T12:42:15","date_gmt":"2021-01-16T03:42:15","guid":{"rendered":"http:\/\/www.emukk.com\/WP\/?p=1796"},"modified":"2021-07-21T23:41:58","modified_gmt":"2021-07-21T14:41:58","slug":"%e6%96%b0%e5%9e%8b%e3%82%b3%e3%83%ad%e3%83%8a%e3%82%a6%e3%82%a4%e3%83%ab%e3%82%b9%ef%bc%88sars-cov-2%ef%bc%89%e3%81%ae%e5%89%8d%e9%a7%86%e4%bd%93%e3%82%bf%e3%83%b3%e3%83%91%e3%82%af%e8%b3%aa%e5%88%87","status":"publish","type":"post","link":"https:\/\/www.emukk.com\/WP\/%e6%96%b0%e5%9e%8b%e3%82%b3%e3%83%ad%e3%83%8a%e3%82%a6%e3%82%a4%e3%83%ab%e3%82%b9%ef%bc%88sars-cov-2%ef%bc%89%e3%81%ae%e5%89%8d%e9%a7%86%e4%bd%93%e3%82%bf%e3%83%b3%e3%83%91%e3%82%af%e8%b3%aa%e5%88%87\/","title":{"rendered":"\u65b0\u578b\u30b3\u30ed\u30ca\u30a6\u30a4\u30eb\u30b9\uff08SARS-CoV-2\uff09\u306e\u524d\u99c6\u4f53\u30bf\u30f3\u30d1\u30af\u8cea\u5207\u65ad\u9175\u7d20\uff08\u30e1\u30a4\u30f3\u30d7\u30ed\u30c6\u30a2\u30fc\u30bc: M<sup>pro<\/sup>\uff09\u3092\u30bf\u30fc\u30b2\u30c3\u30c8\u306b\u3057\u305f\u30b5\u30dd\u30cb\u30f3\u3068\u30bf\u30f3\u30cb\u30f3\u306e\u963b\u5bb3\u5264\u3068\u3057\u3066\u306e\u8a55\u4fa1"},"content":{"rendered":"<p>Ladoke Akintola Univ. of Technology, Ogbomoso, Oyo State Nigeria\u3089\u306e\u30b0\u30eb\u30fc\u30d7\u306f\u3001\u5148\u306e\u30d6\u30ed\u30b0\u3067\u7d39\u4ecb\u3057\u305f\u7814\u7a76\u306b\u8fd1\u3044\u306e\u3067\u3059\u304c\u3001SARS-CoV-2\u306e\u524d\u99c6\u4f53\u30bf\u30f3\u30d1\u30af\u8cea\u5207\u65ad\u9175\u7d20\uff08\u30e1\u30a4\u30f3\u30d7\u30ed\u30c6\u30a2\u30fc\u30bc: M<sup>pro<\/sup>\uff09\u3092\u30bf\u30fc\u30b2\u30c3\u30c8\u3068\u3057\u3066\u3001\u30b5\u30dd\u30cb\u30f3\u3068\u30bf\u30f3\u30cb\u30f3\u306b\u3064\u3044\u3066\u3001\u5206\u5b50\u30c9\u30c3\u30ad\u30f3\u30b0\u30fb\u5206\u5b50\u52d5\u529b\u5b66\u7684\u30b7\u30df\u30e5\u30ec\u30fc\u30b7\u30e7\u30f3\u306b\u3088\u3063\u3066\u3001\u305d\u306e\u963b\u5bb3\u52b9\u679c\u3092\u8a55\u4fa1\u3057\u307e\u3057\u305f<br \/>\n<a href=\"https:\/\/link.springer.com\/article\/10.1007\/s40203-020-00071-w\">https:\/\/link.springer.com\/article\/10.1007\/s40203-020-00071-w<\/a><\/p>\n<p>\u30b5\u30dd\u30cb\u30f3\u306f\u3001\u690d\u7269\u306e\u6839\u3001\u8449\u3001\u830e\u306a\u3069\u306b\u542b\u307e\u308c\u3066\u3044\u307e\u3059\u304c\u3001\u7279\u306b\u30de\u30e1\u79d1\u306e\u690d\u7269\u306b\u591a\u304f\u542b\u307e\u308c\u3066\u304a\u308a\u3001\u6297\u9178\u5316\u4f5c\u7528\u3092\u6301\u3064\u3053\u3068\u3067\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u4e00\u65b9\u3001\u30bf\u30f3\u30cb\u30f3\u306f\u3001\u7a2e\u5b50\u306b\u542b\u307e\u308c\u308b\u6e0b\u307f\u6210\u5206\u3067\u3042\u308a\u3001\u6e0b\u67ff\u306e\u305d\u308c\u304c\u826f\u304f\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u30bf\u30f3\u30cb\u30f3\u306f\u30bf\u30f3\u30d1\u30af\u8cea\u3068\u5f37\u304f\u7d50\u5408\u3057\u3066\u5909\u6027\u3055\u305b\u308b\u4f5c\u7528\u304c\u3042\u308a\u3001\u30bf\u30f3\u30cb\u30f3\u306b\u3088\u308b\u5909\u6027\u4f5c\u7528\u306e\u3053\u3068\u3092\u300c\u53ce\u308c\u3093\u4f5c\u7528\u300d\u3068\u547c\u3073\u307e\u3059\u3002<\/p>\n<p>\u7d50\u679c\u306f\u3001\u4e0b\u8a18\u306e\u3088\u3046\u3067\u3059\u304c\u3001\u30ec\u30e0\u30c7\u30b7\u30d3\u30eb\u306b\u52dd\u308b\u3068\u3082\u52a3\u3089\u306a\u3044\u6297\u30a6\u30a4\u30eb\u30b9\u4f5c\u7528\u3092\u793a\u3059\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002in vivo\u3067\u306e\u8a55\u4fa1\u304c\u671f\u5f85\u3055\u308c\u307e\u3059\u3002<\/p>\n<table width=\"420\">\n<tbody>\n<tr>\n<td width=\"120\">Ligands<\/td>\n<td style=\"text-align: center;\" width=\"150\">Binding affinity (\u0394G) kcal\/mol<\/td>\n<td style=\"text-align: center;\" width=\"150\">Inhibition constant (Ki), \u00b5M<\/td>\n<\/tr>\n<tr>\n<td>\u30b5\u30dd\u30cb\u30f3\u985e<\/td>\n<td><\/td>\n<td><\/td>\n<\/tr>\n<tr>\n<td>Priverogenin A<\/td>\n<td style=\"text-align: center;\">\u2212 8.3<\/td>\n<td style=\"text-align: center;\">0.83<\/td>\n<\/tr>\n<tr>\n<td>Arjunic acid<\/td>\n<td style=\"text-align: center;\">\u2212 8.1<\/td>\n<td style=\"text-align: center;\">1.16<\/td>\n<\/tr>\n<tr>\n<td>Theasapogenol B<\/td>\n<td style=\"text-align: center;\">\u2212 8.1<\/td>\n<td style=\"text-align: center;\">1.16<\/td>\n<\/tr>\n<tr>\n<td>Euscaphic Acid<\/td>\n<td style=\"text-align: center;\">\u2212 8.0<\/td>\n<td style=\"text-align: center;\">1.37<\/td>\n<\/tr>\n<tr>\n<td><\/td>\n<td><\/td>\n<td><\/td>\n<\/tr>\n<tr>\n<td>\u30bf\u30f3\u30cb\u30f3\u985e<\/td>\n<td><\/td>\n<td><\/td>\n<\/tr>\n<tr>\n<td>Punicalagin<\/td>\n<td style=\"text-align: center;\">\u2212 9.0<\/td>\n<td style=\"text-align: center;\">0.25<\/td>\n<\/tr>\n<tr>\n<td>Punicalin<\/td>\n<td style=\"text-align: center;\">\u2212 8.6<\/td>\n<td style=\"text-align: center;\">0.5<\/td>\n<\/tr>\n<tr>\n<td>Ellagic acid<\/td>\n<td style=\"text-align: center;\">\u2212 8.4<\/td>\n<td style=\"text-align: center;\">0.7<\/td>\n<\/tr>\n<tr>\n<td>Corilagin<\/td>\n<td style=\"text-align: center;\">\u2212 8.2<\/td>\n<td style=\"text-align: center;\">&nbsp;0.98<\/td>\n<\/tr>\n<tr>\n<td>Gallagic acid<\/td>\n<td style=\"text-align: center;\">\u2212 8.1<\/td>\n<td style=\"text-align: center;\">1.16<\/td>\n<\/tr>\n<tr>\n<td><\/td>\n<td><\/td>\n<td><\/td>\n<\/tr>\n<tr>\n<td>\u6bd4\u8f03\u5bfe\u8c61<\/td>\n<td><\/td>\n<td><\/td>\n<\/tr>\n<tr>\n<td>Remdesivir<\/td>\n<td style=\"text-align: center;\">\u2212 7.6<\/td>\n<td style=\"text-align: center;\">2.7<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n","protected":false},"excerpt":{"rendered":"<p>Ladoke Akintola Univ. of Technology, Ogbomoso, Oyo State Nigeria\u3089\u306e\u30b0\u30eb\u30fc\u30d7\u306f\u3001\u5148\u306e\u30d6\u30ed\u30b0\u3067\u7d39\u4ecb\u3057\u305f\u7814\u7a76\u306b\u8fd1\u3044\u306e\u3067\u3059\u304c\u3001SARS-CoV-2\u306e\u524d\u99c6\u4f53\u30bf\u30f3\u30d1\u30af<\/p><\/div>\n<div class=\"blog-btn\"><a href=\"https:\/\/www.emukk.com\/WP\/%e6%96%b0%e5%9e%8b%e3%82%b3%e3%83%ad%e3%83%8a%e3%82%a6%e3%82%a4%e3%83%ab%e3%82%b9%ef%bc%88sars-cov-2%ef%bc%89%e3%81%ae%e5%89%8d%e9%a7%86%e4%bd%93%e3%82%bf%e3%83%b3%e3%83%91%e3%82%af%e8%b3%aa%e5%88%87\/\" class=\"home-blog-btn\">\u7d9a\u304d\u3092\u8aad\u3080<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[642],"tags":[],"class_list":["post-1796","post","type-post","status-publish","format-standard","hentry","category-nature-ja"],"aioseo_notices":[],"aioseo_head":"\n\t\t<!-- All in One SEO 4.9.8 - aioseo.com -->\n\t<meta name=\"description\" content=\"Ladoke Akintola Univ. of Technology, Ogbomoso, Oyo Stat\" \/>\n\t<meta name=\"robots\" content=\"max-image-preview:large\" \/>\n\t<meta name=\"author\" content=\"Mx\"\/>\n\t<link rel=\"canonical\" href=\"https:\/\/www.emukk.com\/WP\/%e6%96%b0%e5%9e%8b%e3%82%b3%e3%83%ad%e3%83%8a%e3%82%a6%e3%82%a4%e3%83%ab%e3%82%b9%ef%bc%88sars-cov-2%ef%bc%89%e3%81%ae%e5%89%8d%e9%a7%86%e4%bd%93%e3%82%bf%e3%83%b3%e3%83%91%e3%82%af%e8%b3%aa%e5%88%87\/\" \/>\n\t<meta name=\"generator\" content=\"All in One SEO 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