{"id":1790,"date":"2021-01-16T09:17:29","date_gmt":"2021-01-16T00:17:29","guid":{"rendered":"http:\/\/www.emukk.com\/WP\/?p=1785"},"modified":"2021-01-16T14:52:27","modified_gmt":"2021-01-16T05:52:27","slug":"screening-plant-derived-inhibitors-targeting-sars-cov-2-precursor-protein-main-protease-mpro","status":"publish","type":"post","link":"https:\/\/www.emukk.com\/WP\/en\/screening-plant-derived-inhibitors-targeting-sars-cov-2-precursor-protein-main-protease-mpro\/","title":{"rendered":"Screening plant-derived inhibitors targeting SARS-CoV-2 precursor protein main protease ( Mpro<\/sup>)"},"content":{"rendered":"

When the new coronavirus (SARS-CoV-2) infects host cells, a huge precursor protein is synthesized from RNA derived from the virus. The precursor protein is cleaved by various proteases and becomes functional proteins necessary for the growth of viruses. The main protease (Mpro<\/sup>) is one of the such precursor proteases and is an essential one for the growth of viruses.<\/p>\n

A group of Univ. of Medical Sciences and Technology, Khartoum, Sudan has used this main protease to evaluate the inhibitory effects of plant-derived components used as traditional Sudanese medicines by molecular docking and molecular dynamic simulations.
\nhttps:\/\/link.springer.com\/article\/10.1007\/s40203-020-00073-8<\/a><\/p>\n

As a result, the following plant-der<\/sub>ived ingredients are expected as inhibitors of the novel coronavirus. Expect in vivo ratings.<\/p>\n\n\n\n\n\n\n\n\n
Name<\/td>\nEnergy (kcal\/mol)<\/td>\nPredicted LD50 mg\/kg<\/td>\n<\/tr>\n
Gallic acid<\/td>\n\u2212 17.45<\/td>\n2260<\/td>\n<\/tr>\n
Quercetin<\/td>\n\u2212 15.81<\/td>\n159<\/td>\n<\/tr>\n
Naringin<\/td>\n\u2212 14.50<\/td>\n2300<\/td>\n<\/tr>\n
Capsaicin<\/td>\n\u2212 13.90<\/td>\n\u00a047<\/td>\n<\/tr>\n
Psychotrine<\/td>\n\u2212 13.50<\/td>\n480<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

When the new coronavirus (SARS-CoV-2) infects host cells, a huge precursor protein is synthesized from RNA der<\/p><\/div>\n

\u7d9a\u304d\u3092\u8aad\u3080<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[70],"tags":[],"class_list":["post-1790","post","type-post","status-publish","format-standard","hentry","category-nature-en"],"aioseo_notices":[],"aioseo_head":"\n\t\t\n\t\n\t\n\t\n\t\n\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t