{"id":1767,"date":"2021-01-12T11:33:28","date_gmt":"2021-01-12T02:33:28","guid":{"rendered":"http:\/\/www.emukk.com\/WP\/?p=1762"},"modified":"2021-01-13T21:59:41","modified_gmt":"2021-01-13T12:59:41","slug":"banlec-a-kind-of-lectin-shows-potential-as-an-antiviral-reagent-against-the-new-coronavirus-sars-cov-2","status":"publish","type":"post","link":"https:\/\/www.emukk.com\/WP\/en\/banlec-a-kind-of-lectin-shows-potential-as-an-antiviral-reagent-against-the-new-coronavirus-sars-cov-2\/","title":{"rendered":"BanLec (a kind of Lectin) shows potential as an antiviral reagent against the new coronavirus (SARS-CoV-2)"},"content":{"rendered":"<p>It has already been shown that the new coronavirus (SARS-CoV-2) has 22 N-type glycan modification sites (see, for example, <a href=\"https:\/\/science.sciencemag.org\/content\/369\/6501\/330.long\">https:\/\/science.sciencemag.org\/content\/369\/6501\/330.long<\/a>).<\/p>\n<p>Since SARS-CoV-2 binds strongly to ACE2 receptors, the binding strength of Mannose and GlcNAc-specific lectins was evaluated with molecular docking and molecular dynamic simulation, targeting the glycan (Man3GlcNAc2Fuc) present in RBD&#8217;s Asn343 in the S1 sub unit of the S protein, and evaluated its potential as an antiviral reagent.<br \/>\n<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33292056\/\">https:\/\/pubmed.ncbi.nlm.nih.gov\/33292056\/<\/a><\/p>\n<p>The lectins compared were as follows, and BanLec showed the highest binding strength.<br \/>\nBanLec: -105.99kcal\/mol<br \/>\nNPA: -79kcal\/mol<br \/>\nGRFT: -73.7kcal\/mol<br \/>\nCV-N: -67.3kcal\/mol<br \/>\nUDA: -98.3kcal\/mol<\/p>\n<p>Lectins, however, generally show side effects such as mitogenicity, hemagglutination, inflammation, etc., so confirmation with in vivo is essential.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>It has already been shown that the new coronavirus (SARS-CoV-2) has 22 N-type glycan modification sites (see, <\/p><\/div>\n<div class=\"blog-btn\"><a href=\"https:\/\/www.emukk.com\/WP\/en\/banlec-a-kind-of-lectin-shows-potential-as-an-antiviral-reagent-against-the-new-coronavirus-sars-cov-2\/\" class=\"home-blog-btn\">\u7d9a\u304d\u3092\u8aad\u3080<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[70],"tags":[],"class_list":["post-1767","post","type-post","status-publish","format-standard","hentry","category-nature-en"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/1767","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/comments?post=1767"}],"version-history":[{"count":4,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/1767\/revisions"}],"predecessor-version":[{"id":1776,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/1767\/revisions\/1776"}],"wp:attachment":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/media?parent=1767"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/categories?post=1767"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/tags?post=1767"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}