Dendritic cells (DCs) are at the forefront of the immune reaction.
\nWhen pathogens such as viruses invade, Toll-like receptors (TLR) and C-type lectin receptors (CLRs) expressed on DCs recognize the molecular structure peculiar to pathogens and trigger immune responses.
\nThe CLR of DCs includes DCIR\/CD367\/CLEC4A, DECTIN1\/CD369\/CLEC7A, DECTIN2\/CLEC6A, DNGR1\/CD370\/CLEC9A, MMR\/CD206, DEC205\/CD205, DC-SIGN\/CD209, langerin\/CD207, BDCA2\/CD303\/CLEC4C, etc.
\nThe function of these lectins remain largely unknow, but for example,
\nDCIR binds to high mannose\/fucose glycans and works inhibitory on the secretion of IL12 and TNF\u03b1, while DECTIN1 recognizes \u03b2-1,3-glucans and conversely promotes the secretion of these inflammatory cytokines.<\/p>\n
A group of Univ. Grenoble Alpes discussed how the expression of various CLRs changes in chronic HBV based on experimental results performed using Flow cytometry. There are three subclasses of DC: CD1c\/BDCA1 (cDC2s), CD141\/BDCA3 (cDC1s), and plasmacytoid DCs (pDCs).<\/p>\n Such a change is happening.<\/p>\n Although the changes are very complex, it is worth noting that chronic HBV causes changes in the expression of CLRs in DCs. Dendritic cells (DCs) are at the forefront of the immune reaction. When pathogens such as viruses invade, Toll<\/p><\/div>\n
\nhttps:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cti2.1208<\/a><\/p>\n\nBlood cDC2s: DECTIN1, MMR decreased,
\nLiver cDC2s: DCIR, MMR decreased,
\nBlood cDC1s: DECTIN1, CLEC9A decreased, Fc\u0263 Receptor increased slightly,
\nLiver cDC1s: DCIR, CLEC9A, Fc\u0263 receptor, MMR decreased, DECTIN1 increased slightly,
\nBlood pCDs: Little change,
\nLiver pCDs: DCIR increased, Fc\u03b5 receptor increased slightly.<\/ul>\n
\nOverall, CLR expression seems to be decreasing, which makes it easier for HBV to escape from immune system, right?<\/p>\n","protected":false},"excerpt":{"rendered":"