{"id":1647,"date":"2020-12-26T14:38:41","date_gmt":"2020-12-26T05:38:41","guid":{"rendered":"http:\/\/www.emukk.com\/WP\/?p=1647"},"modified":"2021-07-21T23:45:56","modified_gmt":"2021-07-21T14:45:56","slug":"%e6%85%a2%e6%80%a7%e7%9a%84%e3%81%aahbv%e3%81%a7%e3%81%af%e3%80%81%e6%a8%b9%e7%8a%b6%e7%b4%b0%e8%83%9e%e3%81%aec-%e5%9e%8b%e3%83%ac%e3%82%af%e3%83%81%e3%83%b3%e5%8f%97%e5%ae%b9%e4%bd%93%e3%81%ae","status":"publish","type":"post","link":"https:\/\/www.emukk.com\/WP\/%e6%85%a2%e6%80%a7%e7%9a%84%e3%81%aahbv%e3%81%a7%e3%81%af%e3%80%81%e6%a8%b9%e7%8a%b6%e7%b4%b0%e8%83%9e%e3%81%aec-%e5%9e%8b%e3%83%ac%e3%82%af%e3%83%81%e3%83%b3%e5%8f%97%e5%ae%b9%e4%bd%93%e3%81%ae\/","title":{"rendered":"\u6162\u6027\u7684\u306aHBV\u3067\u306f\u3001\u6a39\u72b6\u7d30\u80de\u306eC-\u578b\u30ec\u30af\u30c1\u30f3\u53d7\u5bb9\u4f53\u306e\u767a\u73fe\u91cf\u306b\u5909\u5316\u304c\u8d77\u3053\u3063\u3066\u3044\u308b"},"content":{"rendered":"<p>\u6a39\u72b6\u7d30\u80de(DC)\u306f\u514d\u5f79\u53cd\u5fdc\u306e\u6700\u524d\u7dda\u306b\u3044\u307e\u3059\u3002<br \/>\n\u30a6\u30a4\u30eb\u30b9\u7b49\u306e\u75c5\u539f\u4f53\u304c\u4fb5\u5165\u3059\u308b\u3068\u3001DC\u306b\u767a\u73fe\u3057\u3066\u3044\u308b\u30c8\u30fc\u30eb\u69d8\u53d7\u5bb9\u4f53\uff08TLR\uff09\u3001C-\u578b\u30ec\u30af\u30c1\u30f3\u53d7\u5bb9\u4f53\uff08CLR\uff09\u3089\u304c\u3001\u75c5\u539f\u4f53\u7279\u6709\u306e\u5206\u5b50\u69cb\u9020\u3092\u8a8d\u8b58\u3057\u3001\u514d\u75ab\u53cd\u5fdc\u306e\u5f15\u304d\u91d1\u3092\u5f15\u304d\u307e\u3059\u3002<br \/>\n\u6a39\u72b6\u7d30\u80de\u306eCLR\u3068\u3057\u3066\u306f\u3001DCIR\/CD367\/CLEC4A, DECTIN1\/CD369\/CLEC7A, DECTIN2\/CLEC6A, DNGR1\/CD370\/CLEC9A, MMR\/CD206, DEC205\/CD205, DC-SIGN\/CD209, langerin\/CD207, BDCA2\/CD303\/CLEC4C\u3089\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002<br \/>\n\u3053\u308c\u3089\u30ec\u30af\u30c1\u30f3\u306e\u6a5f\u80fd\u306b\u3064\u3044\u3066\u306f\u3001\u307e\u3060\u307e\u3060\u4e0d\u660e\u70b9\u304c\u591a\u3044\u306e\u3067\u3059\u304c\u3001\u4f8b\u3048\u3070\u3001<br \/>\nDCIR\u306f\u3001high mannose\/fucose\u7cfb\u306e\u7cd6\u9396\u306b\u7d50\u5408\u3057\u3001IL12\u3084TNF\u03b1\u306e\u5206\u6ccc\u306b\u6291\u5236\u7684\u306b\u50cd\u304d\u3001DECTIN1\u306f\u3001\u03b2-1,3-glucans\u3092\u8a8d\u8b58\u3057\u3001\u9006\u306b\u305d\u308c\u3089\u708e\u75c7\u6027\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u306e\u5206\u6ccc\u3092\u4fc3\u3057\u307e\u3059\u3002<\/p>\n<p>Univ. Grenoble Alpes\u306e\u30b0\u30eb\u30fc\u30d7\u306f\u3001\u6162\u6027\u5316\u3057\u305fHBV\u306b\u304a\u3044\u3066\u3001\u5404\u7a2eCLR\u306e\u767a\u73fe\u304c\u3069\u306e\u3088\u3046\u306b\u5909\u5316\u3057\u3066\u3044\u308b\u304b\u306b\u3064\u3044\u3066\u3001Flow cytometry\u3092\u7528\u3044\u3066\u884c\u308f\u308c\u305f\u5b9f\u9a13\u7d50\u679c\u3092\u5143\u306b\u8003\u5bdf\u3092\u52a0\u3048\u3066\u3044\u307e\u3059\u3002<br \/>\n<a href=\"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cti2.1208\">https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cti2.1208<\/a><\/p>\n<p>DC\u306b\u306f\u3001CD1c\/BDCA1 (cDC2s), CD141\/BDCA3 (cDC1s), plasmacytoid DCs (pDCs)\u3068\u3044\u3046\u4e09\u3064\u306e\u30b5\u30d6\u30af\u30e9\u30b9\u304c\u5b58\u5728\u3057\u307e\u3059\u3002<\/p>\n<ul>\n\u8840\u4e2dcDC2s\uff1aDECTIN1, MMR\u304c\u6e1b\u5c11<br \/>\n\u809d\u81d3\u5185cDC2s\uff1aDCIR, MMR\u304c\u6e1b\u5c11<br \/>\n\u8840\u4e2dcDC1s\uff1aDECTIN1, CLEC9A\u304c\u6e1b\u5c11\u3001Fc\u0263RIIA\u304c\u82e5\u5e72\u5897\u52a0\u3001<br \/>\n\u809d\u81d3\u5185cDC1s\uff1aDCIR, CLEC9A, Fc\u0263\u53d7\u5bb9\u4f53, MMR\u304c\u6e1b\u5c11\u3001DECTIN1\u304c\u82e5\u5e72\u5897\u52a0<br \/>\n\u8840\u4e2dpCDs\uff1a\u307b\u3068\u3093\u3069\u5909\u5316\u306f\u306a\u3044<br \/>\n\u809d\u81d3\u5185pCDs\uff1aDCIR\u304c\u5897\u52a0\u3001Fc\u03b5\u53d7\u5bb9\u4f53\u304c\u82e5\u5e72\u5897\u52a0<\/ul>\n<p>\u3068\u3044\u3046\u3088\u3046\u306a\u5909\u5316\u304c\u8d77\u3053\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n<p>\u975e\u5e38\u306b\u5909\u5316\u306f\u8907\u96d1\u3067\u3059\u304c\u3001HBV\u306b\u6162\u6027\u7684\u306b\u611f\u67d3\u3059\u308b\u3053\u3068\u3067\u3001DC\u306eCLR\u306e\u767a\u73fe\u91cf\u306b\u5909\u5316\u304c\u8d77\u3053\u3063\u3066\u3044\u308b\u3068\u3044\u3046\u73fe\u8c61\u306f\u6ce8\u76ee\u306b\u5024\u3059\u308b\u3068\u601d\u308f\u308c\u307e\u3059\u3002<br \/>\n\u5168\u822c\u7684\u306b\u306f\u3001CLR\u306e\u767a\u73fe\u304c\u6e1b\u5c11\u3057\u3066\u3044\u308b\u3088\u3046\u3067\u3042\u308a\u3001\u305d\u308c\u306b\u3088\u3063\u3066\u3001HBV\u304c\u514d\u75ab\u7cfb\u306e\u653b\u6483\u304b\u3089\u9003\u308c\u3084\u3059\u304f\u306a\u3063\u3066\u3044\u308b\u306e\u3067\u306f\u306a\u3044\u3067\u3057\u3087\u3046\u304b\uff1f<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u6a39\u72b6\u7d30\u80de(DC)\u306f\u514d\u5f79\u53cd\u5fdc\u306e\u6700\u524d\u7dda\u306b\u3044\u307e\u3059\u3002 \u30a6\u30a4\u30eb\u30b9\u7b49\u306e\u75c5\u539f\u4f53\u304c\u4fb5\u5165\u3059\u308b\u3068\u3001DC\u306b\u767a\u73fe\u3057\u3066\u3044\u308b\u30c8\u30fc\u30eb\u69d8\u53d7\u5bb9\u4f53\uff08TLR\uff09\u3001C-\u578b\u30ec\u30af\u30c1\u30f3\u53d7\u5bb9\u4f53\uff08CLR\uff09\u3089\u304c\u3001\u75c5\u539f\u4f53\u7279\u6709\u306e\u5206\u5b50\u69cb\u9020\u3092\u8a8d\u8b58\u3057\u3001\u514d\u75ab\u53cd\u5fdc\u306e\u5f15\u304d\u91d1\u3092\u5f15\u304d\u307e\u3059\u3002 \u6a39<\/p><\/div>\n<div class=\"blog-btn\"><a href=\"https:\/\/www.emukk.com\/WP\/%e6%85%a2%e6%80%a7%e7%9a%84%e3%81%aahbv%e3%81%a7%e3%81%af%e3%80%81%e6%a8%b9%e7%8a%b6%e7%b4%b0%e8%83%9e%e3%81%aec-%e5%9e%8b%e3%83%ac%e3%82%af%e3%83%81%e3%83%b3%e5%8f%97%e5%ae%b9%e4%bd%93%e3%81%ae\/\" class=\"home-blog-btn\">\u7d9a\u304d\u3092\u8aad\u3080<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[642],"tags":[],"class_list":["post-1647","post","type-post","status-publish","format-standard","hentry","category-nature-ja"],"aioseo_notices":[],"aioseo_head":"\n\t\t<!-- All in One SEO 4.9.8 - aioseo.com -->\n\t<meta name=\"description\" content=\"\u6a39\u72b6\u7d30\u80de(DC)\u306f\u514d\u5f79\u53cd\u5fdc\u306e\u6700\u524d\u7dda\u306b\u3044\u307e\u3059\u3002 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