{"id":1641,"date":"2020-12-25T14:06:19","date_gmt":"2020-12-25T05:06:19","guid":{"rendered":"http:\/\/www.emukk.com\/WP\/?p=1636"},"modified":"2020-12-25T14:30:43","modified_gmt":"2020-12-25T05:30:43","slug":"a-new-exosome-marker-for-alzheimers-disease-was-discovered","status":"publish","type":"post","link":"https:\/\/www.emukk.com\/WP\/en\/a-new-exosome-marker-for-alzheimers-disease-was-discovered\/","title":{"rendered":"A new exosome marker for Alzheimer’s disease was discovered"},"content":{"rendered":"

A group of AIST and Kyoto Univ. has discovered a high-performance novel exosome marker as a novel marker for Alzheimer's disease.
\nhttps:\/\/pubmed.ncbi.nlm.nih.gov\/33345458\/<\/a><\/p>\n

They found that in patients with Alzheimer's disease, there was a significant difference in glycan modification of exosomes compared to healthy people, and the exosomes were highly high mannosylated.
\nUsing a high mannose specific lectin, its lectin blotting revealed a very strong band around 80 kDa, which was identified as a marker of exosomes, CD61.<\/p>\n

A sandwich assay (Tim4-\u03b1CD63) assembled with an antibody to the exosome marker CD63 and Tim4 (T cell immunoglobulin and mucin domain-containing protein 4) showed the highest discriminating ability among (CD61, CD41, CD63, and CD9), and the obtained AUC reached 0.957.<\/p>\n

\"\"<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

A group of AIST and Kyoto Univ. has discovered a high-performance novel exosome marker as a novel marker for A<\/p><\/div>\n

\u7d9a\u304d\u3092\u8aad\u3080<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[70],"tags":[],"class_list":["post-1641","post","type-post","status-publish","format-standard","hentry","category-nature-en"],"aioseo_notices":[],"aioseo_head":"\n\t\t\n\t\n\t\n\t\n\t\n\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t