{"id":1641,"date":"2020-12-25T14:06:19","date_gmt":"2020-12-25T05:06:19","guid":{"rendered":"http:\/\/www.emukk.com\/WP\/?p=1636"},"modified":"2020-12-25T14:30:43","modified_gmt":"2020-12-25T05:30:43","slug":"a-new-exosome-marker-for-alzheimers-disease-was-discovered","status":"publish","type":"post","link":"https:\/\/www.emukk.com\/WP\/en\/a-new-exosome-marker-for-alzheimers-disease-was-discovered\/","title":{"rendered":"A new exosome marker for Alzheimer&#8217;s disease was discovered"},"content":{"rendered":"<p>A group of AIST and Kyoto Univ. has discovered a high-performance novel exosome marker as a novel marker for Alzheimer&#39;s disease.<br \/>\n<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33345458\/\">https:\/\/pubmed.ncbi.nlm.nih.gov\/33345458\/<\/a><\/p>\n<p>They found that in patients with Alzheimer&#39;s disease, there was a significant difference in glycan modification of exosomes compared to healthy people, and the exosomes were highly high mannosylated.<br \/>\nUsing a high mannose specific lectin, its lectin blotting revealed a very strong band around 80 kDa, which was identified as a marker of exosomes, CD61.<\/p>\n<p>A sandwich assay (Tim4-\u03b1CD63) assembled with an antibody to the exosome marker CD63 and Tim4 (T cell immunoglobulin and mucin domain-containing protein 4) showed the highest discriminating ability among (CD61, CD41, CD63, and CD9), and the obtained AUC reached 0.957.<\/p>\n<p><a href=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2020\/12\/Tim4-CD63.png\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2020\/12\/Tim4-CD63-298x300.png\" alt=\"\" width=\"298\" height=\"300\" class=\"alignleft size-medium wp-image-1639\" srcset=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2020\/12\/Tim4-CD63-298x300.png 298w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2020\/12\/Tim4-CD63-100x100.png 100w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2020\/12\/Tim4-CD63-150x150.png 150w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2020\/12\/Tim4-CD63.png 499w\" sizes=\"auto, (max-width: 298px) 100vw, 298px\" \/><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>A group of AIST and Kyoto Univ. has discovered a high-performance novel exosome marker as a novel marker for A<\/p><\/div>\n<div class=\"blog-btn\"><a href=\"https:\/\/www.emukk.com\/WP\/en\/a-new-exosome-marker-for-alzheimers-disease-was-discovered\/\" class=\"home-blog-btn\">\u7d9a\u304d\u3092\u8aad\u3080<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[70],"tags":[],"class_list":["post-1641","post","type-post","status-publish","format-standard","hentry","category-nature-en"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/1641","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/comments?post=1641"}],"version-history":[{"count":5,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/1641\/revisions"}],"predecessor-version":[{"id":1646,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/1641\/revisions\/1646"}],"wp:attachment":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/media?parent=1641"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/categories?post=1641"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/tags?post=1641"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}