{"id":16289,"date":"2025-08-01T11:00:32","date_gmt":"2025-08-01T02:00:32","guid":{"rendered":"https:\/\/www.emukk.com\/WP\/?p=16289"},"modified":"2025-08-01T11:04:53","modified_gmt":"2025-08-01T02:04:53","slug":"therapeutic-potentials-targeting-glycan-glycan-binding-proteins-gpb-interactions","status":"publish","type":"post","link":"https:\/\/www.emukk.com\/WP\/en\/therapeutic-potentials-targeting-glycan-glycan-binding-proteins-gpb-interactions\/","title":{"rendered":"Therapeutic potentials targeting Glycan-Glycan Binding Proteins (GPB) interactions"},"content":{"rendered":"

Here is a review paper written by a researcher in Institute of Chemistry, Slovak Academy of Sciences, 845 38 Bratislava, Slovakia about the role of glycans in human.
\nhttps:\/\/www.mdpi.com\/1420-3049\/30\/13\/2678<\/a><\/p>\n

In this paper, therapeutic potentials targeting glycan-glycan-binding proteins (GBPs), such as selectins, galectins, and Siglecs, are summarized as follows.<\/p>\n

    1) Inhibition of GBP\u2013glycan interactions, for example, Uproleselan (Glycomimetics)<\/ol>\n
      2) Monoclonal antibodies targeting glycans, for example, Dinutuximab\/Unituxin (National Cancer Institute) and Naxitamab\/Danyelza (Memorial Sloan Kettering Cancer Center) to target ganglioside GD2<\/ol>\n
        3) Carbohydrate-based vaccines against pathogens and cancer, for example, carbohydrate-based vaccine against the bacteria Haemophilus influenzae type b (Pentacel from Sanofi Pasteur, Hiberix, Merck and Co.), and as vaccines against cancer, Theratope (Biomira), GM2-KLH (Memorial Sloan Kettering Cancer Center), OPT-822 (OBI Pharma), and Racotumomab (Molecular Immunology Center in Havana) targeting sTn antigen, ganglioside GM2, glycolipid Globo H, and ganglioside GM3<\/ol>\n
          4) Immune checkpoint inhibitor (ICI)<\/ol>\n
            5) Altering the biosynthesis of carbohydrate determinants with carbohydrate processing inhibitors (CPIs)<\/ol>\n

            Just for your information.<\/p>\n","protected":false},"excerpt":{"rendered":"

            Here is a review paper written by a researcher in Institute of Chemistry, Slovak Academy of Sciences, 845 38 B<\/p><\/div>\n

            \u7d9a\u304d\u3092\u8aad\u3080<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[7],"tags":[],"class_list":["post-16289","post","type-post","status-publish","format-standard","hentry","category-technology-en"],"aioseo_notices":[],"aioseo_head":"\n\t\t\n\t\n\t\n\t\n\t\n\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t