{"id":16289,"date":"2025-08-01T11:00:32","date_gmt":"2025-08-01T02:00:32","guid":{"rendered":"https:\/\/www.emukk.com\/WP\/?p=16289"},"modified":"2025-08-01T11:04:53","modified_gmt":"2025-08-01T02:04:53","slug":"therapeutic-potentials-targeting-glycan-glycan-binding-proteins-gpb-interactions","status":"publish","type":"post","link":"https:\/\/www.emukk.com\/WP\/en\/therapeutic-potentials-targeting-glycan-glycan-binding-proteins-gpb-interactions\/","title":{"rendered":"Therapeutic potentials targeting Glycan-Glycan Binding Proteins (GPB) interactions"},"content":{"rendered":"<p>Here is a review paper written by a researcher in Institute of Chemistry, Slovak Academy of Sciences, 845 38 Bratislava, Slovakia about the role of glycans in human.<br \/>\n<a href=\"https:\/\/www.mdpi.com\/1420-3049\/30\/13\/2678\">https:\/\/www.mdpi.com\/1420-3049\/30\/13\/2678<\/a><\/p>\n<p>In this paper, therapeutic potentials targeting glycan-glycan-binding proteins (GBPs), such as selectins, galectins, and Siglecs, are summarized as follows.<\/p>\n<ol>1) Inhibition of GBP\u2013glycan interactions, for example, Uproleselan (Glycomimetics)<\/ol>\n<ol>2) Monoclonal antibodies targeting glycans, for example, Dinutuximab\/Unituxin (National Cancer Institute) and Naxitamab\/Danyelza (Memorial Sloan Kettering Cancer Center) to target ganglioside GD2<\/ol>\n<ol>3) Carbohydrate-based vaccines against pathogens and cancer, for example, carbohydrate-based vaccine against the bacteria Haemophilus influenzae type b (Pentacel from Sanofi Pasteur, Hiberix, Merck and Co.), and as vaccines against cancer, Theratope (Biomira), GM2-KLH (Memorial Sloan Kettering Cancer Center), OPT-822 (OBI Pharma), and Racotumomab (Molecular Immunology Center in Havana) targeting sTn antigen, ganglioside GM2, glycolipid Globo H, and ganglioside GM3<\/ol>\n<ol>4) Immune checkpoint inhibitor (ICI)<\/ol>\n<ol>5) Altering the biosynthesis of carbohydrate determinants with carbohydrate processing inhibitors (CPIs)<\/ol>\n<p>Just for your information.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Here is a review paper written by a researcher in Institute of Chemistry, Slovak Academy of Sciences, 845 38 B<\/p><\/div>\n<div class=\"blog-btn\"><a href=\"https:\/\/www.emukk.com\/WP\/en\/therapeutic-potentials-targeting-glycan-glycan-binding-proteins-gpb-interactions\/\" class=\"home-blog-btn\">\u7d9a\u304d\u3092\u8aad\u3080<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[7],"tags":[],"class_list":["post-16289","post","type-post","status-publish","format-standard","hentry","category-technology-en"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/16289","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/comments?post=16289"}],"version-history":[{"count":1,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/16289\/revisions"}],"predecessor-version":[{"id":16290,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/16289\/revisions\/16290"}],"wp:attachment":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/media?parent=16289"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/categories?post=16289"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/tags?post=16289"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}