{"id":1572,"date":"2020-12-16T12:31:58","date_gmt":"2020-12-16T03:31:58","guid":{"rendered":"http:\/\/www.emukk.com\/WP\/?p=1567"},"modified":"2020-12-16T12:46:51","modified_gmt":"2020-12-16T03:46:51","slug":"relationship-between-n-glycans-of-hiv-envelope-protein-and-infectivity-and-neutralizing-antibodies","status":"publish","type":"post","link":"https:\/\/www.emukk.com\/WP\/en\/relationship-between-n-glycans-of-hiv-envelope-protein-and-infectivity-and-neutralizing-antibodies\/","title":{"rendered":"Relationship between N-glycans of HIV envelope protein and infectivity and neutralizing antibodies"},"content":{"rendered":"<p>HIV is a virus with envelope proteins in the same way as SARS-CoV-2, and there have been numerous studies on the structure and glycan modification of that protein. The envelope protein of HIV is called gp160 and is made up of two sub-units, gp41 and gp120. HIV infection is initiated by gp120 binding to CD4 receptors on T cells. Gp120 has 27 N-type glycan modification sites and is known to be strongly glycosylated with high mannose.<\/p>\n<p>A group of Univ. of Alabama at Birmingham has reported about the effects of gp120 glycosylation on infectivity and neutralizing antibodies.<br \/>\n<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33205023\/\">https:\/\/pubmed.ncbi.nlm.nih.gov\/33205023\/<\/a><\/p>\n<p>As a result, it was confirmed that the infectivity increased by 7 to 9 times when there was N262 glycan modification.<br \/>\nIn addition, it was found that N262 glycan modification reduces the neutralization capacity of HIV neutralizing antibodies.<br \/>\nIn particular, PGT151, 35022, 2G12, VRC24, PG16, and PGT145 showed a significant decrease in the capacity.<\/p>\n<p>In this paper, they have discussed possible mechanisms behind these changes using molecular dynamics models.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>HIV is a virus with envelope proteins in the same way as SARS-CoV-2, and there have been numerous studies on t<\/p><\/div>\n<div class=\"blog-btn\"><a href=\"https:\/\/www.emukk.com\/WP\/en\/relationship-between-n-glycans-of-hiv-envelope-protein-and-infectivity-and-neutralizing-antibodies\/\" class=\"home-blog-btn\">\u7d9a\u304d\u3092\u8aad\u3080<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[70],"tags":[],"class_list":["post-1572","post","type-post","status-publish","format-standard","hentry","category-nature-en"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/1572","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/comments?post=1572"}],"version-history":[{"count":2,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/1572\/revisions"}],"predecessor-version":[{"id":1574,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/1572\/revisions\/1574"}],"wp:attachment":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/media?parent=1572"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/categories?post=1572"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/tags?post=1572"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}