{"id":1559,"date":"2020-12-15T13:10:14","date_gmt":"2020-12-15T04:10:14","guid":{"rendered":"http:\/\/www.emukk.com\/WP\/?p=1552"},"modified":"2020-12-15T16:41:59","modified_gmt":"2020-12-15T07:41:59","slug":"the-new-coronavirus-sars-cov-2-is-an-artificial-product-no-matter-how-you-think-about-it","status":"publish","type":"post","link":"https:\/\/www.emukk.com\/WP\/en\/the-new-coronavirus-sars-cov-2-is-an-artificial-product-no-matter-how-you-think-about-it\/","title":{"rendered":"The new coronavirus (SARS-CoV-2) is an artificial product no matter how you think about it"},"content":{"rendered":"<p>There is a noteworthy paper on the origin of the novel coronavirus (SARS-CoV-2).<br \/>\n<a href=\"https:\/\/zenodo.org\/record\/4073131?fbclid=IwAR2VprdWCGzl8NlNpzWPz0QudcBRHZ0dnPPCZNz8Yg2oGfleP1_ZxoipzEI\">https:\/\/zenodo.org\/record\/4073131?fbclid=IwAR2VprdWCGzl8NlNpzWPz0QudcBRHZ0dnPPCZNz8Yg2oGfleP1_ZxoipzEI<\/a><\/p>\n<p>The central points of the discussion are:<\/p>\n<p><strong>RaTG13<\/strong> (96.2%) hosted by horseshoe bat and <strong>MP789<\/strong> (90.1%) hosted by pangolin are close to SARS-CoV-2.<br \/>\nBut,<\/p>\n<ol>\n<li><strong>Syn\/non-syn ratio<\/strong> of spontaneous gene mutations must not fluctuate significantly across the entire region of the S protein, whereas SARS-CoV-2 vs RaTG13 fluctuates over an order of magnitude.<\/li>\n<li>The amino acid sequences in the receptor binding domain (RBD) of S proteins should best bind to the host&#8217;s infected receptors, but RaTG13 and pangolin coronavirus do not bind much to ACE2 of their hosts, horseshoe bat or pangolin.<\/li>\n<li>The E protein of <strong>ZC45<\/strong>, <strong>ZXC21<\/strong>, which is coronavirus in bats, is the same as 100% SARS-CoV-2 and could be the backbone of the SARS-CoV-2 gene sequence.<\/li>\n<li>How the <strong>furin-cleavage site<\/strong> inserted at the junction of the S1\/S2 region could not be rationally explained from a view point of viral evolution.<\/li>\n<\/ol>\n<p>When I start reading this paper, I&#8217;m drawn in as if I were reading a detective story.<br \/>\nAnd finally, you will be convinced that the new coronavirus (SARS-CoV-2) could be an artificial product.<\/p>\n<p>By all means, I recommend you to read it.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>There is a noteworthy paper on the origin of the novel coronavirus (SARS-CoV-2). https:\/\/zenodo.org\/record\/407<\/p><\/div>\n<div class=\"blog-btn\"><a href=\"https:\/\/www.emukk.com\/WP\/en\/the-new-coronavirus-sars-cov-2-is-an-artificial-product-no-matter-how-you-think-about-it\/\" class=\"home-blog-btn\">\u7d9a\u304d\u3092\u8aad\u3080<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[70],"tags":[],"class_list":["post-1559","post","type-post","status-publish","format-standard","hentry","category-nature-en"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/1559","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/comments?post=1559"}],"version-history":[{"count":4,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/1559\/revisions"}],"predecessor-version":[{"id":1565,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/1559\/revisions\/1565"}],"wp:attachment":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/media?parent=1559"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/categories?post=1559"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/tags?post=1559"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}