{"id":1552,"date":"2020-12-15T13:10:14","date_gmt":"2020-12-15T04:10:14","guid":{"rendered":"http:\/\/www.emukk.com\/WP\/?p=1552"},"modified":"2021-07-21T23:48:28","modified_gmt":"2021-07-21T14:48:28","slug":"%e6%96%b0%e5%9e%8b%e3%82%b3%e3%83%ad%e3%83%8a%e3%82%a6%e3%82%a4%e3%83%ab%e3%82%b9%ef%bc%88sars-cov-2%ef%bc%89%e3%81%af%e3%80%81%e3%81%a9%e3%81%86%e8%80%83%e3%81%88%e3%81%a6%e3%82%82%e4%ba%ba%e5%b7%a5","status":"publish","type":"post","link":"https:\/\/www.emukk.com\/WP\/%e6%96%b0%e5%9e%8b%e3%82%b3%e3%83%ad%e3%83%8a%e3%82%a6%e3%82%a4%e3%83%ab%e3%82%b9%ef%bc%88sars-cov-2%ef%bc%89%e3%81%af%e3%80%81%e3%81%a9%e3%81%86%e8%80%83%e3%81%88%e3%81%a6%e3%82%82%e4%ba%ba%e5%b7%a5\/","title":{"rendered":"\u65b0\u578b\u30b3\u30ed\u30ca\u30a6\u30a4\u30eb\u30b9\uff08SARS-CoV-2\uff09\u306f\u3001\u3069\u3046\u8003\u3048\u3066\u3082\u4eba\u5de5\u7684\u306a\u7523\u7269\u3060"},"content":{"rendered":"<p>\u65b0\u578b\u30b3\u30ed\u30ca\u30a6\u30a4\u30eb\u30b9\uff08SARS-CoV-2\uff09\u306e\u7531\u6765\u306b\u3064\u3044\u3066\u3001\u7279\u7b46\u3059\u3079\u304d\u8ad6\u6587\u304c\u3042\u308a\u307e\u3059\u3002<br \/>\n<a href=\"https:\/\/zenodo.org\/record\/4073131?fbclid=IwAR2VprdWCGzl8NlNpzWPz0QudcBRHZ0dnPPCZNz8Yg2oGfleP1_ZxoipzEI\">https:\/\/zenodo.org\/record\/4073131?fbclid=IwAR2VprdWCGzl8NlNpzWPz0QudcBRHZ0dnPPCZNz8Yg2oGfleP1_ZxoipzEI<\/a><\/p>\n<p>\u8b70\u8ad6\u306e\u4e2d\u5fc3\u70b9\u306f\u3001\u4ee5\u4e0b\u3067\u3059\u3002<\/p>\n<p>SARS-CoV-2\u306b\u907a\u4f1d\u5b50\u914d\u5217\u304c\u8fd1\u3044\u3082\u306e\u3068\u3057\u3066\u306f\u3001horseshoe bat\u3092\u5bbf\u4e3b\u3068\u3059\u308b<strong>RaTG13<\/strong>(96.2%\uff09\u304a\u3088\u3073pangolin\u3092\u5bbf\u4e3b\u3068\u3059\u308b<strong>MP789<\/strong>(90.1%)\u3089\u304c\u3042\u308a\u307e\u3059\u3002<br \/>\n\u3057\u304b\u3057\u3001<\/p>\n<ol>\n<li>\u81ea\u7136\u767a\u751f\u7684\u306a\u907a\u4f1d\u5b50\u5909\u7570\u306e<strong>syn\/non-syn ratio<\/strong>\u306f\u3001S\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u5168\u9818\u57df\u306b\u6e21\u3063\u3066\u5927\u304d\u304f\u5909\u52d5\u3057\u3066\u306f\u306a\u3089\u306a\u3044\u306e\u306b\u3001SARS-CoV-2 vs RaTG13\u3067\u306f\u3001\u6841\u9055\u3044\u306b\u6bd4\u7387\u304c\u5909\u5316\u3057\u3066\u3044\u308b<\/li>\n<li>S\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u53d7\u5bb9\u4f53\u7d50\u5408\u30c9\u30e1\u30a4\u30f3(RBD)\u306e\u30a2\u30df\u30ce\u9178\u914d\u5217\u306f\u3001\u5bbf\u4e3b\u306e\u611f\u67d3\u53d7\u5bb9\u4f53\u306b\u6700\u3082\u826f\u304f\u7d50\u5408\u3059\u3079\u304d\u306a\u306e\u306b\u3001RaTG13\u3084pangolin coronavirus\u306f\u3001\u305d\u308c\u3089\u306e\u5bbf\u4e3b\u3067\u3042\u308bhorseshoe bat\u3084pangolin\u306eACE2\u306b\u306f\u3042\u307e\u308a\u7d50\u5408\u3057\u306a\u3044<\/li>\n<li>\u30b3\u30a6\u30e2\u30ea\u306e\u30b3\u30ed\u30ca\u30a6\u30a4\u30eb\u30b9\u3067\u3042\u308b<strong>ZC45<\/strong>, <strong>ZXC21<\/strong>\u306eE\u30bf\u30f3\u30d1\u30af\u8cea\u306f\u3001100%SARS-CoV-2\u3068\u540c\u3058\u3067\u3042\u308a\u3001SARS-CoV-2\u907a\u4f1d\u5b50\u914d\u5217\u306e\u30d0\u30c3\u30af\u30dc\u30fc\u30f3\u306b\u306a\u3063\u3066\u3044\u308b<\/li>\n<li>S1\/S2\u9818\u57df\u306e\u63a5\u5408\u90e8\u4f4d\u306b\u633f\u5165\u3055\u308c\u3066\u3044\u308b<strong>furin-cleavage site<\/strong>\u306f\u3069\u306e\u3088\u3046\u306b\u3057\u3066\u767a\u751f\u3057\u305f\u306e\u304b\u3001\u30a6\u30a4\u30eb\u30b9\u9032\u5316\u8ad6\u7684\u306b\u5408\u7406\u7684\u306b\u8aac\u660e\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u306a\u3044<\/li>\n<\/ol>\n<p>\u3053\u306e\u8ad6\u6587\u3092\u8aad\u307f\u59cb\u3081\u308b\u3068\u3001\u307e\u308b\u3067\u63a8\u7406\u5c0f\u8aac\u3092\u8aad\u3080\u3088\u3046\u306b\u5f15\u304d\u8fbc\u307e\u308c\u3066\u884c\u304d\u307e\u3059\u3002<br \/>\n\u305d\u3057\u3066\u6700\u5f8c\u306b\u306f\u3001\u3042\u306a\u305f\u3082\u65b0\u578b\u30b3\u30ed\u30ca\u30a6\u30a4\u30eb\u30b9\uff08SARS-CoV-2\uff09\u306f\u3001\u4eba\u5de5\u7684\u306a\u7523\u7269\u3060\u3068\u7d0d\u5f97\u3055\u305b\u3089\u308c\u308b\u3067\u3057\u3087\u3046\u3002<\/p>\n<p>\u662f\u975e\u3068\u3082\u3001\u3054\u4e00\u8aad\u3092\u304a\u52e7\u3081\u3057\u307e\u3059\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u65b0\u578b\u30b3\u30ed\u30ca\u30a6\u30a4\u30eb\u30b9\uff08SARS-CoV-2\uff09\u306e\u7531\u6765\u306b\u3064\u3044\u3066\u3001\u7279\u7b46\u3059\u3079\u304d\u8ad6\u6587\u304c\u3042\u308a\u307e\u3059\u3002 https:\/\/zenodo.org\/record\/4073131?fbclid=IwAR2VprdWCGzl8NlNpzWPz0Qu<\/p><\/div>\n<div class=\"blog-btn\"><a href=\"https:\/\/www.emukk.com\/WP\/%e6%96%b0%e5%9e%8b%e3%82%b3%e3%83%ad%e3%83%8a%e3%82%a6%e3%82%a4%e3%83%ab%e3%82%b9%ef%bc%88sars-cov-2%ef%bc%89%e3%81%af%e3%80%81%e3%81%a9%e3%81%86%e8%80%83%e3%81%88%e3%81%a6%e3%82%82%e4%ba%ba%e5%b7%a5\/\" 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