A group from Department of Biochemistry, Faculty of Medicine, Khon Kaen University, Thailand has reported about a new lectin ALA extracted from the seeds of Artocarpus lakoocha.
\nhttps:\/\/www.nature.com\/articles\/s41598-024-84444-7<\/p>\n
ALA exhibits agglutinin activity and has binding specificity to T- and Tn-associated glycoproteins and monosaccharides such as Gal and GalNAc.<\/p>\n
It was confirmed that glycans identified by ALA were elevated in human Cholangiocarcinoma (CCA) tissues.
\nALA significantly reduced cell viability of CCA cells, KKU-100 and KKU-213B, in a dose-dependent manner (up to 30 \u00b5g\/mL) with approximately a 30% decrease observed at the highest concentration. And also, ALA significantly reduced the migration and invasion ability of KKU-100 and KKU-213B cells in a dose-dependent manner with 1\u20132 \u00b5g\/mL which did not affect cell viability.<\/p>\n
These results suggest their therapeutic potential effects on CCA treatments.<\/p>\n","protected":false},"excerpt":{"rendered":"
A group from Department of Biochemistry, Faculty of Medicine, Khon Kaen University, Thailand has reported abou<\/p><\/div>\n