{"id":1513,"date":"2020-12-13T10:23:41","date_gmt":"2020-12-13T01:23:41","guid":{"rendered":"http:\/\/www.emukk.com\/WP\/?p=1508"},"modified":"2020-12-13T11:41:08","modified_gmt":"2020-12-13T02:41:08","slug":"a-new-therapy-for-the-new-coronavirus-covid-19-topoisomerase-1-inhibitors-suppress-gene-transcription-induced-by-sars-cov-2-infection-in-one-go","status":"publish","type":"post","link":"https:\/\/www.emukk.com\/WP\/en\/a-new-therapy-for-the-new-coronavirus-covid-19-topoisomerase-1-inhibitors-suppress-gene-transcription-induced-by-sars-cov-2-infection-in-one-go\/","title":{"rendered":"A new therapy for the new coronavirus (COVID-19): Topoisomerase 1 inhibitors suppress gene transcription induced by SARS-CoV-2 infection &#8220;in one go&#8221;"},"content":{"rendered":"<p>It is well known that when the new coronavirus (COVID-19) becomes severe, it causes acute respiratory prompt syndrome and multiple organ failure, resulting in cytokine storms.<br \/>\nTo mitigate lung inflammation, the use of inhibitors against certain cytokines, such as IL-6 and GM-CSF, is limited. This is because there are many signaling molecules and pathways are involved in the triggering of cytokine storms.<br \/>\nTherefore, the following group focused on inhibitors of DNA Topoisomerase-1 in order to inhibit the transcription process of genes induced by viral infection &#8220;in one go&#8221;<br \/>\n<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33299999\/\">https:\/\/pubmed.ncbi.nlm.nih.gov\/33299999\/<\/a><\/p>\n<p>Topoisomerase-1 is a necessary enzyme to unwind DNA double helix.<br \/>\nIn vivo experiments using hamsters, it was shown that genes expressed high by viral infection were down regulated by the Topoisomerase-1 inhibitor, and thereby SARS-CoV-2-induced lung<br \/>\ninflammation was suppressed.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>It is well known that when the new coronavirus (COVID-19) becomes severe, it causes acute respiratory prompt s<\/p><\/div>\n<div class=\"blog-btn\"><a href=\"https:\/\/www.emukk.com\/WP\/en\/a-new-therapy-for-the-new-coronavirus-covid-19-topoisomerase-1-inhibitors-suppress-gene-transcription-induced-by-sars-cov-2-infection-in-one-go\/\" class=\"home-blog-btn\">\u7d9a\u304d\u3092\u8aad\u3080<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[70],"tags":[],"class_list":["post-1513","post","type-post","status-publish","format-standard","hentry","category-nature-en"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/1513","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/comments?post=1513"}],"version-history":[{"count":6,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/1513\/revisions"}],"predecessor-version":[{"id":1514,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/1513\/revisions\/1514"}],"wp:attachment":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/media?parent=1513"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/categories?post=1513"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/tags?post=1513"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}