{"id":1498,"date":"2020-12-11T12:09:45","date_gmt":"2020-12-11T03:09:45","guid":{"rendered":"http:\/\/www.emukk.com\/WP\/?p=1495"},"modified":"2020-12-11T14:14:30","modified_gmt":"2020-12-11T05:14:30","slug":"symptoms-of-the-new-coronavirus-covid-19-can-be-mimicked-by-sars-cov-2-protein-cocktail-s-n-p-protein","status":"publish","type":"post","link":"https:\/\/www.emukk.com\/WP\/en\/symptoms-of-the-new-coronavirus-covid-19-can-be-mimicked-by-sars-cov-2-protein-cocktail-s-n-p-protein\/","title":{"rendered":"Conditions of the new coronavirus (COVID-19) can be mimicked by a SARS-CoV-2 protein cocktail (S, N, P-protein)"},"content":{"rendered":"<p>A group of La Paz University Essential, Spain has suggested a treatment based on the novel coronavirus (COVID-19) symptoms that can be completely mimicked by a protein cocktail of SARS-CoV-2.<br \/>\n<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33283062\/\">https:\/\/pubmed.ncbi.nlm.nih.gov\/33283062\/<\/a><\/p>\n<p>In patients with COVID-19, inflammation and cytokine storms are induced, and il-1\u03b2, IL-6, and TNF-\u03b1 are known to be highly expressed. This early stage can be explained by excessive activation of monocytes and macrophages. In the later stages of COVID-19, adaptive immunity plays a critical role, and in severe patients, lymphocytes are significantly reduced.<\/p>\n<p>Blood cells obtained from healthy people was incubated with SARS-CoV-2 S-protein, N-protein and P-protein cocktails and developed a phenotype that mimics the COVID-19 condition. For example, in monocytes, HLA-DR, the signal path for antigen presentation, was reduced, and PD-L1, a immune checkpoint ligand, was highly expressed.<br \/>\nFrom these results, it was suggested that the use of inhibitors (antibodies) for immune checkpoint molecules could lead to effective treatment. Actually, a clinical trial using camrelizumab (PD-1 antibody) is in progress.<\/p>\n<p>Expect progress.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>A group of La Paz University Essential, Spain has suggested a treatment based on the novel coronavirus (COVID-<\/p><\/div>\n<div class=\"blog-btn\"><a href=\"https:\/\/www.emukk.com\/WP\/en\/symptoms-of-the-new-coronavirus-covid-19-can-be-mimicked-by-sars-cov-2-protein-cocktail-s-n-p-protein\/\" class=\"home-blog-btn\">\u7d9a\u304d\u3092\u8aad\u3080<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[70,7],"tags":[],"class_list":["post-1498","post","type-post","status-publish","format-standard","hentry","category-nature-en","category-technology-en"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/1498","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/comments?post=1498"}],"version-history":[{"count":7,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/1498\/revisions"}],"predecessor-version":[{"id":1506,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/1498\/revisions\/1506"}],"wp:attachment":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/media?parent=1498"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/categories?post=1498"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/tags?post=1498"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}