{"id":14940,"date":"2024-09-15T06:38:11","date_gmt":"2024-09-14T21:38:11","guid":{"rendered":"https:\/\/www.emukk.com\/WP\/?p=14940"},"modified":"2024-09-15T06:40:21","modified_gmt":"2024-09-14T21:40:21","slug":"galectin-8-alters-non-canonical-tgf-%ce%b2-response-in-crc-cells-and-suppresses-crc-progression","status":"publish","type":"post","link":"https:\/\/www.emukk.com\/WP\/en\/galectin-8-alters-non-canonical-tgf-%ce%b2-response-in-crc-cells-and-suppresses-crc-progression\/","title":{"rendered":"Galectin-8 alters non-canonical TGF-\u03b2 response in CRC cells and suppresses CRC progression"},"content":{"rendered":"<p>A group from Genomics Research Center, Academia Sinica, Taipei, Taiwan has reported about a glycan-binding protein modulated the TGF-\u03b2-driven signaling and metastasis of colorectal cancer (CRC).<br \/>\n<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC11375092\/\">https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC11375092\/<\/a><\/p>\n<p>This study demonstrate that galectin-8 alters non-canonical TGF-\u03b2 response in CRC cells and suppresses CRC progression, although Galectin-8 is not a canonical regand of TGF-\u03b2 Receprtor.<\/p>\n<p>In detail, in the absence of galectin-8, TGF-\u03b2 binds to type II TGF-\u03b2 receptor (T\u03b2RII), thereby promoting epithelial-mesenchymal transition (EMT).<br \/>\nIn the presence of galectin-8, galectin-8 binds to T\u03b2RII through galactosylaeted-glycans, resulting in a decrease of TGF-\u03b2 signaling-mediated EMT.<br \/>\nIt was also shown that galectin-8 expression is downregulated during CRC progression.<br \/>\nThe expression of galectin-8 is significantly lower in T4 stage than that in T1 stage.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>A group from Genomics Research Center, Academia Sinica, Taipei, Taiwan has reported about a glycan-binding pro<\/p><\/div>\n<div class=\"blog-btn\"><a href=\"https:\/\/www.emukk.com\/WP\/en\/galectin-8-alters-non-canonical-tgf-%ce%b2-response-in-crc-cells-and-suppresses-crc-progression\/\" class=\"home-blog-btn\">\u7d9a\u304d\u3092\u8aad\u3080<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[70],"tags":[],"class_list":["post-14940","post","type-post","status-publish","format-standard","hentry","category-nature-en"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/14940","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/comments?post=14940"}],"version-history":[{"count":1,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/14940\/revisions"}],"predecessor-version":[{"id":14941,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/14940\/revisions\/14941"}],"wp:attachment":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/media?parent=14940"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/categories?post=14940"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/tags?post=14940"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}