{"id":1488,"date":"2020-12-10T12:57:32","date_gmt":"2020-12-10T03:57:32","guid":{"rendered":"http:\/\/www.emukk.com\/WP\/?p=1480"},"modified":"2020-12-10T13:16:59","modified_gmt":"2020-12-10T04:16:59","slug":"importance-of-%ce%b23gn-t6-glycosyltransferase-enzyme-involved-in-the-synthesis-of-core3-o-glycan-in-pancreatic-ductal-adenocarcinoma","status":"publish","type":"post","link":"https:\/\/www.emukk.com\/WP\/en\/importance-of-%ce%b23gn-t6-glycosyltransferase-enzyme-involved-in-the-synthesis-of-core3-o-glycan-in-pancreatic-ductal-adenocarcinoma\/","title":{"rendered":"Importance of \u03b23Gn-T6 Glycosyltransferase (enzyme involved in the synthesis of Core3 O-glycan) in pancreatic ductal adenocarcinoma"},"content":{"rendered":"<p>It is well known that changes in the expression of mucin-type O-glycans can be seen in the initiation, progression, and metastasis of cancers.<br \/>\nA group of AIST has reported a study on the relationship between clinicopathology and O-glycans in pancreatic ductal adenocarcinoma.<br \/>\n<a href=\"https:\/\/journals.plos.org\/plosone\/article?id=10.1371\/journal.pone.0242851\">https:\/\/journals.plos.org\/plosone\/article?id=10.1371\/journal.pone.0242851<\/a><\/p>\n<p>In pancreatic ductal adenocarcinoma, Tn-antigen and sialyl-LewisX antigen are highly expressed.<br \/>\nHowever, there was no correlation between these expression levels and disease-free survival (DFS).<br \/>\nInterestingly, however, there was a clear correlation between \u03b23Gn-6T glycosyltransferase and DFS, indicating that higher expression of \u03b23Gn-6T resulted in longer DFS.<br \/>\nThe \u03b23Gn-6T glycosyltransferase is a necessary enzyme for the synthesis of Core3 O-glycans.<\/p>\n<p>At this stage, the mechanism of why the Core3 structure and its extended structure increase DFS is not known.<br \/>\nLet&#8217;s look forward to the progress of research in the future.\u00a0 That may lead to the outcome of breaking down the general concern that &#8220;Glycan is just a physiological expression of disease state&#8221;, .<\/p>\n<p><a href=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2020\/12\/\u03b23GnT-6_PDAC.png\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-medium wp-image-1484\" src=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2020\/12\/\u03b23GnT-6_PDAC-300x213.png\" alt=\"\" width=\"300\" height=\"213\" srcset=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2020\/12\/\u03b23GnT-6_PDAC-300x213.png 300w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2020\/12\/\u03b23GnT-6_PDAC-600x427.png 600w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2020\/12\/\u03b23GnT-6_PDAC-768x546.png 768w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2020\/12\/\u03b23GnT-6_PDAC.png 882w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>It is well known that changes in the expression of mucin-type O-glycans can be seen in the initiation, progres<\/p><\/div>\n<div class=\"blog-btn\"><a href=\"https:\/\/www.emukk.com\/WP\/en\/importance-of-%ce%b23gn-t6-glycosyltransferase-enzyme-involved-in-the-synthesis-of-core3-o-glycan-in-pancreatic-ductal-adenocarcinoma\/\" class=\"home-blog-btn\">\u7d9a\u304d\u3092\u8aad\u3080<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[70],"tags":[],"class_list":["post-1488","post","type-post","status-publish","format-standard","hentry","category-nature-en"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/1488","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/comments?post=1488"}],"version-history":[{"count":2,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/1488\/revisions"}],"predecessor-version":[{"id":1490,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/1488\/revisions\/1490"}],"wp:attachment":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/media?parent=1488"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/categories?post=1488"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/tags?post=1488"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}