{"id":14785,"date":"2024-05-27T07:53:04","date_gmt":"2024-05-26T22:53:04","guid":{"rendered":"https:\/\/www.emukk.com\/WP\/?p=14785"},"modified":"2024-05-27T07:57:22","modified_gmt":"2024-05-26T22:57:22","slug":"glycosylation-of-adeno-associated-virus-aav-used-for-gene-therapy-was-investigated-using-lectin-microarrays","status":"publish","type":"post","link":"https:\/\/www.emukk.com\/WP\/en\/glycosylation-of-adeno-associated-virus-aav-used-for-gene-therapy-was-investigated-using-lectin-microarrays\/","title":{"rendered":"Glycosylation of adeno-associated virus (AAV) used for gene therapy was investigated using Lectin microarrays"},"content":{"rendered":"<p>A group from Department of Biotechnology, Graduate School of Engineering, Osaka University, Osaka, Japan has reported about glycosylation of recombinant adeno-associated virus serotype 6 (rAAV6) which is used for Gene therapy.<br \/>\nhttps:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC11107246\/<\/p>\n<p>Glycosylation of recombinant adeno-associated viruses (rAAVs) that are used for gene theraphy has been evaluated by Lectin microarrays.<br \/>\nIt was found that rAAV6 was mainly O-glycosylated with the mucin-type glycans, O-GalNAc (Tn antigen), and mono- and di-sialylated Gal\u03b21-3GalNAc (T antigen).<\/p>\n<p>The purpose of this study was to see if glycosylation of rAAV6 can affect gene therapy safety in terms of immunogenecity and overall transduction efficacy of this method.<br \/>\nHowever, unfortunately, this study still could not evaluate the direct influence of mucin-type O-glycans on transduction efficiency.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>A group from Department of Biotechnology, Graduate School of Engineering, Osaka University, Osaka, Japan has r<\/p><\/div>\n<div class=\"blog-btn\"><a href=\"https:\/\/www.emukk.com\/WP\/en\/glycosylation-of-adeno-associated-virus-aav-used-for-gene-therapy-was-investigated-using-lectin-microarrays\/\" class=\"home-blog-btn\">\u7d9a\u304d\u3092\u8aad\u3080<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[7],"tags":[],"class_list":["post-14785","post","type-post","status-publish","format-standard","hentry","category-technology-en"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/14785","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/comments?post=14785"}],"version-history":[{"count":2,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/14785\/revisions"}],"predecessor-version":[{"id":14787,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/14785\/revisions\/14787"}],"wp:attachment":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/media?parent=14785"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/categories?post=14785"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/tags?post=14785"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}