{"id":14771,"date":"2024-05-10T07:17:42","date_gmt":"2024-05-09T22:17:42","guid":{"rendered":"https:\/\/www.emukk.com\/WP\/?p=14771"},"modified":"2024-05-10T07:19:45","modified_gmt":"2024-05-09T22:19:45","slug":"t-antigen-could-be-a-biomarker-of-progression-free-survival-in-patients-with-glioblastoma","status":"publish","type":"post","link":"https:\/\/www.emukk.com\/WP\/en\/t-antigen-could-be-a-biomarker-of-progression-free-survival-in-patients-with-glioblastoma\/","title":{"rendered":"T-antigen could be a biomarker of progression-free survival in patients with glioblastoma ?"},"content":{"rendered":"<p>A group from Department of Neurosurgery, the First Affiliated Hospital of Anhui Medical University, Hefei, China has reported that T-antigen could be a biomarker of progression-free survival (PFS) in patients with glioblastoma (GMB).<br \/>\n<a href=\"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/acn3.52082\">https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/acn3.52082<\/a><\/p>\n<p>They concluded from studies using Lectin microarrays that serum Jacalin-probed T-antigen levels, which were positively correlated with those in GBM tissues, may be used as a non-invasive biomarker of PFS, predicting GBM recurrences.<\/p>\n<p>However, blog author thinks that their conclusion is problematic, because the glycan binding specificity of Jacalin is quite broad covering GlcNAc\u03b21-3GalNAc (Core3), Sia\u03b12-3Gal\u03b21-3GalNAc (sialyl T), Gal\u03b21-3GalNAc (T-antigen), \u03b1-GalNAc (Tn-antigen), and also PNA could not discriminate glioblastoma so well, although it has high binding specificity to Gal\u03b21-3GalNAc (T-antigen). <\/p>\n<p><a href=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2024\/05\/T-antigen_glioblastoma.png\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2024\/05\/T-antigen_glioblastoma-300x158.png\" alt=\"\" width=\"300\" height=\"158\" class=\"alignnone size-medium wp-image-14769\" srcset=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2024\/05\/T-antigen_glioblastoma-300x158.png 300w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2024\/05\/T-antigen_glioblastoma-600x317.png 600w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2024\/05\/T-antigen_glioblastoma-1024x541.png 1024w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2024\/05\/T-antigen_glioblastoma-768x405.png 768w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2024\/05\/T-antigen_glioblastoma-1000x528.png 1000w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2024\/05\/T-antigen_glioblastoma-230x121.png 230w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2024\/05\/T-antigen_glioblastoma-350x185.png 350w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2024\/05\/T-antigen_glioblastoma-480x253.png 480w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2024\/05\/T-antigen_glioblastoma.png 1074w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>A group from Department of Neurosurgery, the First Affiliated Hospital of Anhui Medical University, Hefei, Chi<\/p><\/div>\n<div class=\"blog-btn\"><a href=\"https:\/\/www.emukk.com\/WP\/en\/t-antigen-could-be-a-biomarker-of-progression-free-survival-in-patients-with-glioblastoma\/\" class=\"home-blog-btn\">\u7d9a\u304d\u3092\u8aad\u3080<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[70,7],"tags":[],"class_list":["post-14771","post","type-post","status-publish","format-standard","hentry","category-nature-en","category-technology-en"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/14771","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/comments?post=14771"}],"version-history":[{"count":1,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/14771\/revisions"}],"predecessor-version":[{"id":14772,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/14771\/revisions\/14772"}],"wp:attachment":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/media?parent=14771"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/categories?post=14771"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/tags?post=14771"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}