{"id":1464,"date":"2020-12-09T13:25:15","date_gmt":"2020-12-09T04:25:15","guid":{"rendered":"http:\/\/www.emukk.com\/WP\/?p=1459"},"modified":"2020-12-09T13:54:32","modified_gmt":"2020-12-09T04:54:32","slug":"%e7%9b%b4%e8%85%b8%e7%99%8c%e3%81%a8tn-%e6%8a%97%e5%8e%9f-2","status":"publish","type":"post","link":"https:\/\/www.emukk.com\/WP\/en\/%e7%9b%b4%e8%85%b8%e7%99%8c%e3%81%a8tn-%e6%8a%97%e5%8e%9f-2\/","title":{"rendered":"Colorectal Cancer and Tn-Antigen"},"content":{"rendered":"<p>A group from Fukushima Medical University has discussed about a key-point on colorectal cancer immunotherapy based on colorectal cancer and Tn-antigen.<br \/>\n<a href=\"https:\/\/www.mdpi.com\/1422-0067\/21\/23\/9081\">https:\/\/www.mdpi.com\/1422-0067\/21\/23\/9081<\/a><\/p>\n<p>In cancer, mutations are accumulated in the genome and epigenome. In colorectal cancer, 85% are derived from chromosomal instability and 15% from deficient mismatch-repair (dMMR).<br \/>\nIt is also well known that in cancer, aberrant glycans are expressed on the cell surface, and O-type glycans are truncated, and resulting Tn-antigens are highly expressed. Tn-antigen binds to macrophage MGL and promotes il-10 secretion and acts immuno-suppressively, as well as inducing T-cell apoptosis. As a result, cancer cells evade immunity attacks.<\/p>\n<p>Cancer cells with deficient mismatch-repair have significantly higher expression of Tn-antigen than those that are not. In addition, those types of cancer cells tend to have less infiltration of CD8+ T-cells and lower expression of PD-L1 as an immune checkpoint molecule. Therefore, they have concluded that immunotherapy targeting on Tn-antigens and inhibition of immune checkpoint molecules may be effective for colorectal cancer with a strong deficient mismatch-repair.<br \/>\n<a href=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2020\/12\/Colorectal-Cancer_Tn-antigen.png\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2020\/12\/Colorectal-Cancer_Tn-antigen-150x150.png\" alt=\"\" width=\"150\" height=\"150\" class=\"alignleft size-thumbnail wp-image-1462\" srcset=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2020\/12\/Colorectal-Cancer_Tn-antigen-150x150.png 150w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2020\/12\/Colorectal-Cancer_Tn-antigen-300x300.png 300w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2020\/12\/Colorectal-Cancer_Tn-antigen-100x100.png 100w\" sizes=\"auto, (max-width: 150px) 100vw, 150px\" \/><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>A group from Fukushima Medical University has discussed about a key-point on colorectal cancer immunotherapy b<\/p><\/div>\n<div class=\"blog-btn\"><a href=\"https:\/\/www.emukk.com\/WP\/en\/%e7%9b%b4%e8%85%b8%e7%99%8c%e3%81%a8tn-%e6%8a%97%e5%8e%9f-2\/\" class=\"home-blog-btn\">\u7d9a\u304d\u3092\u8aad\u3080<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[70],"tags":[],"class_list":["post-1464","post","type-post","status-publish","format-standard","hentry","category-nature-en"],"aioseo_notices":[],"aioseo_head":"\n\t\t<!-- All in One SEO 4.9.8 - 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